PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24751922-8	2014	We propose that residue 6 (leucine) at the N-terminus is important for the chemotaxis-inducing activity of flounder IL-8.	Leucine	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	116-120	
9452482-9	1998	Furthermore, the peptide aldehyde N-acetyl-Leu-Leu-norleucinal, an agent that blocks both IkappaBalpha proteolysis and NF-kappaB subunit translocation, abrogates recombinant human TNFalpha-inducible IL-8 gene transcription.	Leucine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	199-203	
20512787-4	2010	After 24 h, glutamine inhibited IL-8 production significantly (p<0.05) at 2, 5 and 10 mM (to 82, 73 and 72% of control), whereas leucine reduced IL-8 production significantly only at 10 mM (66%) and proline at 5 and 10 mM (71 and 52%).	Leucine	132-139	C-X-C motif chemokine ligand 8	Homo sapiens	148-152	
20512787-8	2010	Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells.	Leucine	37-44	C-X-C motif chemokine ligand 8	Homo sapiens	67-71	
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Leucine	115-118	C-X-C motif chemokine ligand 8	Homo sapiens	33-37	
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Leucine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	Leucine	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	145-149	
9698598-4	1998	However, pretreatment of the cells with the proteasome inhibitor N-cbz-Leu-Leu-leucinal (MG-132, 10 microM) reversed the effects of TNF-alpha on IL-8 release from A549 cells (as determined with an enzyme-linked immunosorbent assay [ELISA]) and on IL-8 gene transcription (as determined with reporter-gene assays).	Leucine	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	247-251	
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Leucine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	104-108	
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Leucine	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	212-216	
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Leucine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	67-80	
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Leucine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	82-86	
9916736-6	1999	Consistent with this interpretation, migrating cells incorporated over 10 times as much [3H]leucine into IL-8 as did nonmotile neutrophils exposed to chemoattractants.	Leucine	92-99	C-X-C motif chemokine ligand 8	Homo sapiens	105-109	
9485196-2	1998	It shares CXCR2 with all neutrophil-activating chemokines, which like IL-8 have a conserved Glu-Leu-Arg (ELR) N-terminal motif, but is generally considered to be the only relevant agonist for CXCR1.	Leucine	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
8140420-2	1994	An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.	Leucine	70-77	C-X-C motif chemokine ligand 8	Homo sapiens	3-7	
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Leucine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
8558067-10	1996	Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity.	Leucine	49-52	C-X-C motif chemokine ligand 8	Homo sapiens	151-155	
7531692-3	1995	Examination of the sequences of the CXC chemokines reveals that the highly conserved leucine, corresponding to Leu25 in IL-8, is always replaced by tyrosine in CC chemokines.	Leucine	85-92	C-X-C motif chemokine ligand 8	Homo sapiens	120-124	
8344717-8	1993	The optimal concentration in the chemotactic activity of CT/IL-8, equivalent to that of bacterial chemotactic peptide fMet-Leu-Phe (10 nM), was found to be 5 nM.	Leucine	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	60-64	
40394-5	1979	Incorporation of leucine was then stimulated by low fluoride concentrations (0.5 and 0.9 mM), and the effect on thymidine incorporation was eradicated up to 1.3 mM-NaF.	Leucine	17-24	C-X-C motif chemokine ligand 8	Homo sapiens	164-167	
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	65-78	
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	86-90	
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176	
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176	
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Leucine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	172-176	
35280694-5	2022	The activation of Stat3 induced the secretion of glutamic acid-leucine-arginine (ELR) motif CXCLs (CXCL1, CXCL2, CXCL3 and CXCL8) in tumor cells.	Leucine	63-70	C-X-C motif chemokine ligand 8	Homo sapiens	123-128	
33404125-2	2021	Tumor necrosis factor (TNF)-alpha/interleukin (IL)-23/IL-17 inflammatory pathway may be involved in the pathogenesis of PPP, and the skin lesions manifest the enhanced expression of IL-8 in keratinocytes and increased levels of antimicrobial peptide cathelicidin, leucine leucine-37 in vesicles/pustules.	Leucine	264-271	C-X-C motif chemokine ligand 8	Homo sapiens	182-186	
33582555-3	2021	C/EBPbeta is a leucine-zipper transcription factor that regulates expression of a variety of inflammatory cytokines or chemokines, such as IL-8, G-CSF (granulocyte colony stimulating factor), and GM-CSF (granulocyte macrophage colony stimulating factor) which induce neutrophil infiltration and differentiation.	Leucine	15-22	C-X-C motif chemokine ligand 8	Homo sapiens	139-143