PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11468348-7 2001 The side chains of residues Leu 66, Val 69, and Leu 70, which are shielded internally in the IL-2 structure, are involved in interactions with the Fab in the complex studied. Leucine 28-31 interleukin 2 Homo sapiens 93-97 19341362-3 2009 Glutamine, a mixture of leucine, aspartic acid and glycine, and a mixture of leucine, glutamine and aspartic acid, were the most effective for the expression of IL-2. Leucine 77-84 interleukin 2 Homo sapiens 161-165 25451252-5 2014 Modification of human interleukin-2 (IL-2) through codons with high gene copy number and high codon usage bias (IL-2 HH, modified on Leu, Thr, Glu) significantly increased protein productivity in CHO-K1 cells. Leucine 133-136 interleukin 2 Homo sapiens 22-35 25451252-5 2014 Modification of human interleukin-2 (IL-2) through codons with high gene copy number and high codon usage bias (IL-2 HH, modified on Leu, Thr, Glu) significantly increased protein productivity in CHO-K1 cells. Leucine 133-136 interleukin 2 Homo sapiens 37-41 25451252-5 2014 Modification of human interleukin-2 (IL-2) through codons with high gene copy number and high codon usage bias (IL-2 HH, modified on Leu, Thr, Glu) significantly increased protein productivity in CHO-K1 cells. Leucine 133-136 interleukin 2 Homo sapiens 112-116 11468348-7 2001 The side chains of residues Leu 66, Val 69, and Leu 70, which are shielded internally in the IL-2 structure, are involved in interactions with the Fab in the complex studied. Leucine 48-51 interleukin 2 Homo sapiens 93-97 9237811-9 1997 Furthermore, during the course of the study we have found that mutein Asp20 --> Leu is an IL-2 antagonist. Leucine 83-86 interleukin 2 Homo sapiens 93-97 9295038-2 1997 In contrast, mutations at the tyrosine or leucine residues in the C-terminal YxxL segment abrogate signals for interleukin (IL)-2 production but do not prevent tyrosine phosphorylation of the N-terminal tyrosine of the ITAM, lck association with the ITAM, activation of phospholipase C-gamma1 or calcium mobilization. Leucine 42-49 interleukin 2 Homo sapiens 111-129 1840730-3 1991 Recombinant interleukin-2 (rIL-2) normalizes the cytotoxic activity of PBMNC from pregnant women against NK-sensitive target cells in a dose- and time-dependent manner, without modification in the normal amounts of HNK-1+, CD16+ (Leu 11, or CD11b+ (OKM-1) present in these effector populations. Leucine 230-233 interleukin 2 Homo sapiens 12-25 8505330-3 1993 We demonstrate that the in-frame deletion of 60 amino acids, from Asn204 to Glu263 in DAB389-IL-2, results in complete loss of cytotoxic activity, whereas when the amphipathic regions from Asp208 to Ser220 and Ala244 to His258 are replaced with idealized amphipathic helices composed of repeating Glu, Lys, and Leu residues, the mutant fusion toxin has low but detectable activity. Leucine 311-314 interleukin 2 Homo sapiens 93-97 12237717-3 1996 However after changing 52 Glu, 53 Leu or 54 Lys to Pro respectively the CD spectra were markedly changed and the activities were decreased significantly, showing that these three amino acids in IL-2 were integrated in the alpha-helix structure and very important for their biological functions. Leucine 34-37 interleukin 2 Homo sapiens 194-198 1710239-3 1991 This molecule is able to mediate positive signals to the lymphocytes as the anti-CD69 mAb (MLR3, AIM, Leu 23) in synergism with phorbol esters induce IL-2 production and proliferation of lymphocytes. Leucine 102-105 interleukin 2 Homo sapiens 150-154 35360108-12 2022 Interestingly, certain butyrate-producing bacteria increase significantly after IL-2 treatment, like Lachnospiraceae, Pseudobutyrivibrio, etc., and are associated with a rise in L-Asparagine and L-Leucine. Leucine 197-204 interleukin 2 Homo sapiens 80-84 2654291-6 1989 In contrast to unstimulated cells, IL-4 alone induced marked cell proliferation and LAK activity as well as Leu-19+ cells from in vitro IL-2 preactivated PBMC or null cells, and did not inhibit IL-2 induced cell proliferation, LAK activity, Leu-19+ cells and IL-2R(p55) expression, but rather augmented them with low doses of IL-2. Leucine 108-111 interleukin 2 Homo sapiens 136-140 2627161-5 1989 Pretreatment of the mononuclear cells with the monoclonal antibody to the HLA-DQ framework (Leu 10), but not the HLA-DR framework (OKIal), blocked the induction of IL2 responsiveness. Leucine 92-95 interleukin 2 Homo sapiens 164-167 2902918-0 1988 Appearance and phenotypic characterization of circulating Leu 19+ cells in cancer patients receiving recombinant interleukin 2. Leucine 58-61 interleukin 2 Homo sapiens 113-126 2521310-4 1989 Upon addition in low ratios to Leu 11-depleted cells, Leu 11-enriched fractions increased antigen-induced IL-2 production three-fold (P less than 0.05), whereas at higher ratios IL-2 production was suppressed P less than 0.01. Leucine 54-57 interleukin 2 Homo sapiens 106-110 2521310-6 1989 In the presence of small numbers (5%) of Leu 11-enriched cells, however, monocytes down-regulated IL-2 production of Leu 11-depleted cell cultures. Leucine 41-44 interleukin 2 Homo sapiens 98-102 2521310-6 1989 In the presence of small numbers (5%) of Leu 11-enriched cells, however, monocytes down-regulated IL-2 production of Leu 11-depleted cell cultures. Leucine 117-120 interleukin 2 Homo sapiens 98-102 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 94-97 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 94-97 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 57-70 2466783-2 1988 This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu). Leucine 106-109 interleukin 2 Homo sapiens 72-76 3257776-2 1988 Isolation of circulating Leu-19+ lymphokine-activated killer effector cells from cancer patients receiving recombinant IL-2. Leucine 25-28 interleukin 2 Homo sapiens 33-43 3286766-2 1988 Role of Leu-19 (NKH1)-positive recombinant IL-2-activated cultures of lymphocytes infiltrating human ovarian tumors. Leucine 8-11 interleukin 2 Homo sapiens 43-47 3259252-3 1988 In this study, we describe an activation antigen, Leu-23, that is rapidly induced and phosphorylated after IL-2 stimulation of NK cells and a subset of low buoyant density T lymphocytes. Leucine 50-53 interleukin 2 Homo sapiens 107-111 3259252-5 1988 Since within 18 h after exposure to IL-2, essentially all NK cells express Leu-23, these findings indicate that all peripheral blood NK cells are responsive to stimulation by IL-2. Leucine 75-78 interleukin 2 Homo sapiens 36-40 3259252-5 1988 Since within 18 h after exposure to IL-2, essentially all NK cells express Leu-23, these findings indicate that all peripheral blood NK cells are responsive to stimulation by IL-2. Leucine 75-78 interleukin 2 Homo sapiens 175-179 3257776-2 1988 Isolation of circulating Leu-19+ lymphokine-activated killer effector cells from cancer patients receiving recombinant IL-2. Leucine 25-28 interleukin 2 Homo sapiens 119-123 3104452-6 1987 Our findings are consistent with the concept that Leu-5b delivers a signal to IL 2-responsive cells that prevents their subsequent proliferation and development of cytotoxicity, but that only the former event, i.e., proliferation, is reconstituted by the addition of IL 1 beta. Leucine 50-53 interleukin 2 Homo sapiens 78-82 3116737-6 1987 The results showed that IL-2 increased the number of cells positive to Leu 11, the so-called active NK cells. Leucine 71-74 interleukin 2 Homo sapiens 24-28 3311212-2 1987 Current evidence suggests that this cell population is comprised predominantly of IL-2-activated CD3 negative Leu 11+ NK cells and a minor proportion of Leu 11+ CD3+ MHC unrestricted type II cytotoxic T cells. Leucine 110-113 interleukin 2 Homo sapiens 82-86 3537549-4 1986 Results indicated that less than 1000 Leu-4+ T cells in the presence of 98% Leu-12+ B cells could produce an equivalent amount of IL-2 produced by the 40,000 T cells estimated in the unsorted population. Leucine 38-41 interleukin 2 Homo sapiens 130-134 3510252-7 1986 Cytotoxic activity present in PBL or in PBL pretreated with IL 2 was shown to be associated with both Leu-11+ and Leu-11- cell populations. Leucine 102-105 interleukin 2 Homo sapiens 60-64 3510252-7 1986 Cytotoxic activity present in PBL or in PBL pretreated with IL 2 was shown to be associated with both Leu-11+ and Leu-11- cell populations. Leucine 114-117 interleukin 2 Homo sapiens 60-64 7106972-0 1982 Lymphokine-induced uptake of [14C]glucosamine, [14C]glucose, and [3H]leucine by macrophages. Leucine 69-76 interleukin 2 Homo sapiens 0-10