PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11877024-5 2000 The mutation in the patients" ALAS2 gene was exon 5 A523G, causing threonine to alanine; and exon 3 T372C, leucine to proline. Leucine 107-114 5'-aminolevulinate synthase 2 Homo sapiens 30-35 16234850-6 2005 A database search for proteins potentially regulated by oxygen tension revealed that ALAS2 contained a sequence of amino acids (LXXLAP where L is leucine, X is any amino acid, A is alanine, and P is proline) not occurring in ALAS1, which may be hydroxylated under normoxic conditions (21% O2) and target the enzyme for ubiquitination and degradation by the proteasome. Leucine 146-153 5'-aminolevulinate synthase 2 Homo sapiens 85-90