PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34350135-4	2021	Much research has focused on toll-like receptors and more recently the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 (NLRP3) inflammasome, which is required for the processing and release of IL-1beta.	Leucine	101-108	interleukin 1 alpha	Homo sapiens	222-230	
34867921-1	2021	Nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome-mediated interleukin-1 beta (IL-1beta) production is one of the crucial responses in innate immunity upon infection with viruses including influenza A virus (IAV) and is modulated by both viral and host cellular proteins.	Leucine	30-37	interleukin 1 alpha	Homo sapiens	121-129	
34536551-4	2021	Nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome, whose activation and assembly significantly affect the release of IL-1beta, is a crucial effector activated by a variety of metabolites.	Leucine	46-53	interleukin 1 alpha	Homo sapiens	169-177	
34768828-2	2021	Nucleotide-binding oligomerization domain (NOD)-Leucine-rich repeats (LRR)-containing receptors (NLRs), also called nucleotide-binding oligomerization (NOD)-like receptors (NLRs), are major cytosolic pattern recognition receptors (PRRs), their involvement in the orchestration of innate immunity and host defense against bacteria, viruses, fungi and parasites, often results in the cleavage of gasdermin and the release of IL-1beta and IL-18, should be tightly regulated.	Leucine	48-55	interleukin 1 alpha	Homo sapiens	423-431	
34489689-5	2021	The NACHT, leucine-rich repeat (LRR), and pyrin (PYD) domains-containing protein 3 (NLRP3) inflammasome regulates IL-1beta and IL-18 secretion and gasdermin D-mediated pyroptosis and plays a key role in innate immunity.	Leucine	11-18	interleukin 1 alpha	Homo sapiens	114-122	
34059097-1	2021	BACKGROUND: Cryopyrin-associated periodic syndrome (CAPS) is a life-long, autoinflammatory disease associated with a gain-of-function mutation in the nucleotide-binding domain, leucine-rich repeat family, pyrin domain containing 3 (NLRP3) gene, which result in uncontrolled production of IL-1beta and chronic inflammation.	Leucine	177-184	interleukin 1 alpha	Homo sapiens	288-296	
35237974-5	2022	Importantly, activation of the nucleotide oligomerization domain leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome activates the caspase-1 protease and results in the generation and release of potent pro-inflammatory cytokines, IL-1beta and IL-18.	Leucine	65-72	interleukin 1 alpha	Homo sapiens	257-265	
35311434-2	2022	Drugs blocking the NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome/interleukin-1beta (IL-1beta) axis are beneficial in patients with multiple recurrences.	Leucine	26-33	interleukin 1 alpha	Homo sapiens	125-133	
35351143-5	2022	It has been reported that the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) 3 inflammasome, which contributes to the activation of interleukin-1 beta (IL-1beta), might be related to the progression of endometriosis.	Leucine	73-80	interleukin 1 alpha	Homo sapiens	204-212	
33708197-5	2021	We demonstrate that the maturation and secretion of IL-1beta during SFTSV infection is mediated by the nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin-containing domain 3 (NLRP3) inflammasome.	Leucine	142-149	interleukin 1 alpha	Homo sapiens	52-60	
32505910-5	2020	IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta.	Leucine	87-94	interleukin 1 alpha	Homo sapiens	0-8	
32610117-0	2020	The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation.	Leucine	4-11	interleukin 1 alpha	Homo sapiens	52-56	
33227837-2	2020	The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing (NLRP) 3 inflammasome triggers the activation of inflammatory caspases and maturation of interleukin (IL)-1beta and -18, and has been linked to various human autoinflammatory and autoimmune diseases.	Leucine	31-38	interleukin 1 alpha	Homo sapiens	176-198	
32423023-1	2020	The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense.	Leucine	38-45	interleukin 1 alpha	Homo sapiens	325-333	
31302424-3	2019	Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation.	Leucine	30-37	interleukin 1 alpha	Homo sapiens	251-259	
31689135-2	2019	As IL-1beta can be produced by the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domains-containing protein 3 (NLRP3) inflammasome, this study determined whether RLX targeted the inflammasome to inhibit the profibrotic TGF-beta1/IL-1beta axis in primary human cardiac myofibroblasts (HCMFs) in vitro and in mice with isoproterenol (ISO)-induced cardiomyopathy in vivo.	Leucine	78-85	interleukin 1 alpha	Homo sapiens	3-11	
30776150-7	2019	Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response.	Leucine	27-34	interleukin 1 alpha	Homo sapiens	125-133	
30776150-7	2019	Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response.	Leucine	27-34	interleukin 1 alpha	Homo sapiens	337-345