PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27327351-7	2016	Following injury in young mice, leucine supplementation was observed to elevate only p-p70S6K.	Leucine	32-39	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	87-93	
27327351-9	2016	Additionally in aged mice, leucine was shown to elicit higher content of relative p70S6K post-injury.	Leucine	27-34	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	82-88	
26551463-4	2015	ER stress markers in each muscle were quantified, and the anabolic response to leucine was assessed by measuring the phosphorylation state of S6K1 in soleus and EDL using an ex vivo muscle model.	Leucine	79-86	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	142-146	
26551463-7	2015	S6K1 response to leucine was impaired in soleus, but not in EDL, suggesting that anabolic resistance contributes to soleus weight loss in old mice.	Leucine	17-24	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	0-4	
25439029-5	2014	However, only p70S6k(Thr389) exhibited a dose-dependent response to leucine with all treatments higher than control (~4-fold; P < .001) and at least 5 mM higher than the 1.5-mM concentration (1.2-fold; P < .02).	Leucine	68-75	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	14-20	
25439029-9	2014	The phosphorylation of p70S6k(Thr389) follows a leucine dose-response relationship, although this was not reflected by the acute protein synthetic response.	Leucine	48-55	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	23-29	
24349566-3	2013	We observed increased phosphorylation of p70s6k in the mouse hypothalamus after an acute oral gavage of leucine.	Leucine	104-111	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	41-47	
22648621-7	2012	Neither total protein content, nor de novo protein synthesis was affected, despite leucine-induced increased 4E-BP1 and S6K1 phosphorylation.	Leucine	83-90	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	120-124	
19882215-11	2010	We conclude that leucine is unique amongst the amino acids in its capacity to stimulate both mTOR and 4EBP1 phosphorylation and to enhance p70S6K1 signalling.	Leucine	17-24	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	139-146	
18767117-2	2008	Leu, Ile, and Val increased S6K1 phosphorylation compared to that measured in AA-deprived cells.	Leucine	0-3	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	28-32	
18602970-3	2008	Western blot analyses revealed that the leucine-induced phosphorylation of p70 S6 kinase (p70S6K), a key regulator of translation initiation, was significantly higher in WY-treated cells than in control and clofibrate-treated cells.	Leucine	40-47	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	75-88	
18602970-3	2008	Western blot analyses revealed that the leucine-induced phosphorylation of p70 S6 kinase (p70S6K), a key regulator of translation initiation, was significantly higher in WY-treated cells than in control and clofibrate-treated cells.	Leucine	40-47	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	90-96	
18602970-7	2008	Pre-treatment of the cells with PD98059 (ERK1/2 kinase inhibitor) prevented the phosphorylation of ERK1/2 and decreased the leucine-induced phosphorylation of p70S6K.	Leucine	124-131	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	159-165	
18602970-8	2008	It is concluded that WY increased the leucine-induced phosphorylation of target proteins involving in translation initiation via ERK/p70S6K pathway, but impaired the signaling for elongation process, suggesting that p70S6K phosphorylation may be essential, but not sufficient for the activation of entire targets for protein translation in WY-treated cells.	Leucine	38-45	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	133-139	
18602970-8	2008	It is concluded that WY increased the leucine-induced phosphorylation of target proteins involving in translation initiation via ERK/p70S6K pathway, but impaired the signaling for elongation process, suggesting that p70S6K phosphorylation may be essential, but not sufficient for the activation of entire targets for protein translation in WY-treated cells.	Leucine	38-45	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	216-222	
17978888-2	2008	Leucine increased the phosphorylation state of mTOR, on both Ser2448 and Ser2481, and its downstream effectors, p70(S6k), S6 and 4E-BP1.	Leucine	0-7	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	116-119	
17623010-6	2007	Treatment with leucine increased phosphorylation of mTOR and p70(S6k), caused hyperphosphorylation of 4E-BP1, reduced the amount of 4E-BP1 associated with eIF4E and caused an increase in the eIF4G-eIF4E complex, together with a reduction in phosphorylation of eEF2.	Leucine	15-22	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	65-68	
16772439-10	2006	The ability of leucine to promote phosphorylation of 4E-BP1 and S6K as well as enhance the assembly of the eIF4F complex was unimpaired in CCK-deficient mice.	Leucine	15-22	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	64-67	
34126555-8	2021	RESULTS: Leucine increased the phosphorylation of S6K and 4E-BP1 in a dose-dependent manner.	Leucine	9-16	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	50-53	
34126555-9	2021	Pretreatment with IGF-I for 5 h further increased the stimulatory effect of leucine on the phosphorylation of S6K and 4E-BP1 in C2C12 cells.	Leucine	76-83	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	110-113	
34126555-13	2021	Likewise, Sestrin2 siRNA attenuated leucine-induced S6K phosphorylation in L6 cells.	Leucine	36-43	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	52-55	
34118944-7	2021	In contrast, in C2C12 cells, 1 mM leucine increased mTORC1 and S6K1 phosphorylation (P < 0.05), which was inhibited by 2 mg/ml chloroquine.	Leucine	34-41	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	63-67