PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23783244-5 2014 Levels of several signaling proteins increased significantly while leucine-induced phosphorylation of mTOR and downstream proteins, 4e-BP1 and S6K1, was completely suppressed. Leucine 67-74 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 132-138 30761631-6 2019 Supplementation of leucine improved the phosphorylation of mammalian target of rapamycin (mTOR), eukaryotic initiation factor 4E-binding protein 1 (4EBP1) and substrates ribosomal protein S6 kinase 1 (p70S6K). Leucine 19-26 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 148-153 29795412-4 2018 Leucine starvation suppressed polysome formation and was the only tested condition that caused a significant decrease in 4EBP1 phosphorylation or increase in 4EBP1 binding to eIF4E, but effects of leucine starvation were not replicated by overexpressing nonphosphorylatable 4EBP1. Leucine 0-7 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 121-126 29795412-4 2018 Leucine starvation suppressed polysome formation and was the only tested condition that caused a significant decrease in 4EBP1 phosphorylation or increase in 4EBP1 binding to eIF4E, but effects of leucine starvation were not replicated by overexpressing nonphosphorylatable 4EBP1. Leucine 0-7 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 158-163 29795412-4 2018 Leucine starvation suppressed polysome formation and was the only tested condition that caused a significant decrease in 4EBP1 phosphorylation or increase in 4EBP1 binding to eIF4E, but effects of leucine starvation were not replicated by overexpressing nonphosphorylatable 4EBP1. Leucine 0-7 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 158-163 30265371-9 2019 We found that the gene expressions of mTOR, S6K1, and 4E-BP1 were significantly (P < 0.05) stimulated only in the embryonic breast muscle, and not in the other embryonic tissues, by in ovo feeding of L-Leu. Leucine 203-208 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 54-60 25553480-3 2015 Specifically, leucine activates the mammalian target of rapamycin (mTOR) signaling pathway, including the 70 kDa ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein 1 (4EBP1) to stimulate protein synthesis in skeletal muscle and adipose tissue and to promote mitochondrial biogenesis, resulting in enhanced cellular respiration and energy partitioning. Leucine 14-21 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 154-209 25553480-3 2015 Specifically, leucine activates the mammalian target of rapamycin (mTOR) signaling pathway, including the 70 kDa ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein 1 (4EBP1) to stimulate protein synthesis in skeletal muscle and adipose tissue and to promote mitochondrial biogenesis, resulting in enhanced cellular respiration and energy partitioning. Leucine 14-21 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 211-216 22442136-6 2012 The effects of EtOH and Leu were associated with coordinate changes in the phosphorylation state of mTOR, raptor, and their downstream targets 4EBP1 and S6K1. Leucine 24-27 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 143-148 22391631-4 2012 Although less than HP, p70 ribosomal S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E binding protein 1 (4EBP1) association with regulatory associated protein of mammalian target of rapamycin was greater in LP+L than LP, resulting in higher S6K1 and 4EBP1 phosphorylation. Leucine 219-220 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 60-115 22391631-4 2012 Although less than HP, p70 ribosomal S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E binding protein 1 (4EBP1) association with regulatory associated protein of mammalian target of rapamycin was greater in LP+L than LP, resulting in higher S6K1 and 4EBP1 phosphorylation. Leucine 219-220 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 117-122 20473536-6 2010 Compared with the control group, dietary supplementation with 0.55% L-leucine for 2 weeks increased (P<0.05): (1) the phosphorylated levels of S6K1 and 4E-BP1; (2) protein synthesis in skeletal muscle, liver, the heart, kidney, pancreas, spleen, and stomach; and (3) daily weight gain by 61%. Leucine 68-77 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 155-161 21906315-9 2011 In contrast, the deficiency of D-(+)-glucose or L-leucine used primarily pathway #2 to down-regulate the phosphorylation of S6K1, but they also secondarily down-regulated the phosphorylation of 4E-BP1 and up-regulated the expression of p27. Leucine 48-57 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 194-200 21293034-10 2011 Importantly, Arg, Leu, Gln, and glucose increased the abundance of phosphorylated MTOR, RPS6K, RPS6, and EIF4EBP1 proteins as well as NOS and ODC1 proteins, but only Arg increased the abundance of IFNT protein. Leucine 18-21 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 105-113 15228219-2 2004 In the current study, we compared the effects of L- and D-enantiomers of leucine on the phosphorylation of 4E-BP1 and S6K1. Leucine 73-80 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 107-113 17707924-4 2007 Preincubation with glutathione also prevented 4E-BP1, eIF4E and Mnk-1 phosphorylation induced by leucine, as well as enhancement of procollagen alpha1(I) protein levels. Leucine 97-104 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 46-52 16897753-4 2006 Treatment of HSC with 5 mM leucine did not alter half-life or steady state levels of procollagen alpha1(I) mRNA, but caused an increase in procollagen alpha1(I) protein that correlated with changes of components involved in translational regulation, like enhanced 4E-BP1, Mnk-1, and eIF4E phosphorylation. Leucine 27-34 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 264-270 16365087-5 2006 A number of mechanisms, including phosphorylation of ribosomal protein S6 Kinase, eukaryotic initiation factor (eIF)4E binding protein-1, and eIF4G, contribute to the effect of leucine on translation initiation. Leucine 177-184 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 82-136 17505052-5 2007 Although the ability of mTOR to respond to insulin-like growth factor (IGF)-I is not disrupted by sepsis, the ability of leucine to increase 4E-BP1 and S6K1 phosphorylation is greatly attenuated. Leucine 121-128 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 141-147 15228219-4 2004 Food-deprived (18 h) rats were orally administered 135 mg/100 g body weight L-leucine, D-leucine or alpha-KIC and were sacrificed after 1 h. L-Leucine administration had an obvious stimulatory effect on the phosphorylation of 4E-BP1 and S6K1 in both skeletal muscle and liver while D-leucine was much less effective, indicating that the effect of leucine is stereospecific. Leucine 141-150 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 226-232 11238774-2 2001 Oral administration of leucine stimulates protein synthesis in association with hyperphosphorylation of the translational repressor, eukaryotic initiation factor (eIF) 4E binding protein 1 (4E-BP1), resulting in enhanced availability of the mRNA cap-binding protein eIF4E, for binding eIF4G and forming the active eIF4F complex. Leucine 23-30 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 133-188 11790952-3 2002 Leucine mediated signaling results in a stimulation of initiation of mRNA translation and involves increases in the phosphorylation status of the translational repression 4E-BP1 and the ribosomal protein S6 kinase S6K1. Leucine 0-7 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 171-177 12611592-3 2003 Amino acids, especially branched-chain amino acids, such as leucine, promote phosphorylation of 4E-BP1 and S6K1, and permit insulin to further increase their phosphorylation. Leucine 60-67 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 96-102 11238774-2 2001 Oral administration of leucine stimulates protein synthesis in association with hyperphosphorylation of the translational repressor, eukaryotic initiation factor (eIF) 4E binding protein 1 (4E-BP1), resulting in enhanced availability of the mRNA cap-binding protein eIF4E, for binding eIF4G and forming the active eIF4F complex. Leucine 23-30 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 190-196 9812990-5 1998 Leucine, but not histidine, additionally caused a redistribution of eIF4E from the inactive eIF4E.4E-BP1 complex to the active eIF4E.eIF4G complex. Leucine 0-7 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 98-104 10723090-3 2000 The structure-activity relationships of a putative L-leucine recognition site in adipocytes (LeuR(A)) that regulates TOR activity were analyzed by examining the effects of leucine analogues on the rapamycin-sensitive phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), an index of TOR activity. Leucine 51-60 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 265-297 10723090-4 2000 Several amino acids that are structurally related to leucine strongly stimulated 4E-BP1 phosphorylation at concentrations greater than the EC(50) value for leucine. Leucine 53-60 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 81-87 10723090-4 2000 Several amino acids that are structurally related to leucine strongly stimulated 4E-BP1 phosphorylation at concentrations greater than the EC(50) value for leucine. Leucine 156-163 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 81-87 10206976-5 1999 In the present study, leucine stimulated phosphorylation of the eIF4E-binding protein, 4E-BP1, in L6 myoblasts, resulting in dissociation of eIF4E from the inactive eIF4E.4E-BP1 complex. Leucine 22-29 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 87-93 10206976-5 1999 In the present study, leucine stimulated phosphorylation of the eIF4E-binding protein, 4E-BP1, in L6 myoblasts, resulting in dissociation of eIF4E from the inactive eIF4E.4E-BP1 complex. Leucine 22-29 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 171-177 9812990-7 1998 The changes in 4E-BP1 phosphorylation and eIF4E redistribution associated with leucine deprivation were not observed in the presence of insulin. Leucine 79-86 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 15-21 9814971-4 1998 Studies on subsets of amino acids and individual amino acids showed that L-leucine was the amino acid responsible for most of the effects on 4E-BP1 phosphorylation; however, the presence of other amino acids was required to observe a maximal effect. Leucine 73-82 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 141-147 9814971-0 1998 Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Leucine 79-88 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 46-52 9814971-8 1998 Half-maximal stimulation of 4E-BP1 phosphorylation occurred at approximately 430 microM; therefore, the response was linear within the range of circulating concentrations of leucine found in various nutritional states. Leucine 174-181 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 28-34 9774438-5 1998 The transamination product of leucine, alpha-ketoisocaproic acid, also stimulates PHAS-I phosphorylation although the transamination products of isoleucine and valine are ineffective. Leucine 30-37 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 82-88 9774438-10 1998 The branched-chain amino acid, leucine, also exerts similar effects on PHAS-I phosphorylation in isolated pancreatic islets. Leucine 31-38 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 71-77