PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18753640-9 2008 A prototypic TLR3 ligand induced apoptosis in a greater fraction of human retinal pigment epithelial cells with the Leu-Leu genotype than those with the Leu-Phe genotype and in a greater fraction of wild-type mice than Tlr3(-/-) mice. Leucine 116-119 toll like receptor 3 Homo sapiens 13-17 18753640-9 2008 A prototypic TLR3 ligand induced apoptosis in a greater fraction of human retinal pigment epithelial cells with the Leu-Leu genotype than those with the Leu-Phe genotype and in a greater fraction of wild-type mice than Tlr3(-/-) mice. Leucine 120-123 toll like receptor 3 Homo sapiens 13-17 18753640-9 2008 A prototypic TLR3 ligand induced apoptosis in a greater fraction of human retinal pigment epithelial cells with the Leu-Leu genotype than those with the Leu-Phe genotype and in a greater fraction of wild-type mice than Tlr3(-/-) mice. Leucine 120-123 toll like receptor 3 Homo sapiens 13-17 33422554-5 2021 A total of 126 common positively selected codons were identified in 10 TLR genes of avian, and most sites were located in the extracellular leucine-rich repeat (LRR) functional domains, and both environment and feeding habits were external factors driving the evolution of avian TLR genes. Leucine 140-147 toll like receptor 3 Homo sapiens 71-74 15226270-7 2004 Furthermore, alanine scanning of the linker region demonstrated that the Phe(732), Leu(742) and Gly(743) in the TLR3 cytoplasmic linker region are essential for ligand-induced NF-kappaB and IFN-beta promoter activation. Leucine 83-86 toll like receptor 3 Homo sapiens 112-116 33422554-5 2021 A total of 126 common positively selected codons were identified in 10 TLR genes of avian, and most sites were located in the extracellular leucine-rich repeat (LRR) functional domains, and both environment and feeding habits were external factors driving the evolution of avian TLR genes. Leucine 140-147 toll like receptor 3 Homo sapiens 279-282 32124747-6 2019 The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5). Leucine 139-142 toll like receptor 3 Homo sapiens 162-167