PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34076707-3 2021 This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mice and macrophages on nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)/interleukin-1beta (IL-1beta) signaling pathway. Leucine 133-140 NLR family, pyrin domain containing 3 Mus musculus 164-169 34480147-1 2021 The nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) inflammasome is essential in inflammation and inflammatory disorders. Leucine 31-38 NLR family, pyrin domain containing 3 Mus musculus 97-102 34172438-5 2021 Furthermore, mitigation of intra-articular inflammation by targeting the NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3) inflammasome protects articular cartilage from damage in a murine model of knee septic arthritis. Leucine 124-131 NLR family, pyrin domain containing 3 Mus musculus 73-78 33941658-5 2021 The combined injection of sterile cecal content (SCC) and the gut commensal bacteria Bacteroides fragilis leads to IL-1beta-dependent peritonitis, which was mitigated in mice deficient in NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome components. Leucine 222-229 NLR family, pyrin domain containing 3 Mus musculus 188-193 34646372-1 2021 Aberrant activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome drives the development of many complex inflammatory diseases, such as obesity, Alzheimer"s disease, and atherosclerosis. Leucine 57-64 NLR family, pyrin domain containing 3 Mus musculus 126-131 34423275-1 2021 Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1beta (IL-1beta). Leucine 26-33 NLR family, pyrin domain containing 3 Mus musculus 80-85 35512472-9 2022 Moreover, ambient PM exposure activated the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome and increased the inflammatory response, as indicated by the increases in interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in the serum and kidney, as well as the upregulation of specific renal fibrosis-related markers (transforming growth factor-beta1 and p-Smad2) in the kidney tissues of mice. Leucine 74-81 NLR family, pyrin domain containing 3 Mus musculus 105-110 34641747-1 2021 AIMS: To explore the role of nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome in ambient fine particulate matter (PM2.5)-related metabolic disorders. Leucine 59-66 NLR family, pyrin domain containing 3 Mus musculus 90-95 35085893-1 2022 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro. Leucine 109-116 NLR family, pyrin domain containing 3 Mus musculus 160-165 35464766-1 2022 Purpose: Activation of NLR (nucleotide-binding and leucine-rich repeat immune receptor) family pyrin domain containing 3 (NLRP3) inflammasome mediating interleukin- (IL-) 1beta secretion has emerged as an important component of inflammatory processes in atherogenesis. Leucine 51-58 NLR family, pyrin domain containing 3 Mus musculus 122-127 35284463-5 2022 We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-kappaB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3). Leucine 179-186 NLR family, pyrin domain containing 3 Mus musculus 210-215 35106716-14 2022 Expression of nucleotide-binding leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome components and inflammatory cytokines, mitochondrial dysfunction, and ERS were all alleviated by leonurine. Leucine 33-40 NLR family, pyrin domain containing 3 Mus musculus 92-97 34874278-2 2022 The deubiquitinase BRCA1-BRCA2-containing complex subunit 3 (BRCC3)-mediated nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome activation participates in this progress. Leucine 107-114 NLR family, pyrin domain containing 3 Mus musculus 165-170 35148014-2 2022 Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome was identified as a key mediator of inflammation, and excessive activation of the NLRP3 inflammasome was shown to contribute to the pathogenesis of a wide variety of diseases. Leucine 57-64 NLR family, pyrin domain containing 3 Mus musculus 110-115 35148014-2 2022 Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome was identified as a key mediator of inflammation, and excessive activation of the NLRP3 inflammasome was shown to contribute to the pathogenesis of a wide variety of diseases. Leucine 57-64 NLR family, pyrin domain containing 3 Mus musculus 212-217 33358726-3 2021 Increasing evidence shows that the inflammatory response, mediated by activated nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasomes, is associated with the onset and progression of a wide range of diseases of the CNS. Leucine 124-131 NLR family, pyrin domain containing 3 Mus musculus 176-181 33931568-1 2021 Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome activation results in potent therapeutic effects in a wide variety of preclinical inflammatory disease models. Leucine 59-66 NLR family, pyrin domain containing 3 Mus musculus 139-144 33169332-1 2021 Recent researches showed that nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome inhibition exerted dopaminergic neuroprotection in cellular or animal models of Parkinson"s disease (PD). Leucine 60-67 NLR family, pyrin domain containing 3 Mus musculus 91-96 33041005-1 2020 The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF). Leucine 34-41 NLR family, pyrin domain containing 3 Mus musculus 99-104 33295913-3 2021 Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues. Leucine 130-137 NLR family, pyrin domain containing 3 Mus musculus 166-171 33098156-1 2020 In the brain, NLRP3 (Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3) inflammasome is mainly expressed in microglia located in the hippocampus and other mood-regulated regions, which are particularly susceptible to stress. Leucine 64-71 NLR family, pyrin domain containing 3 Mus musculus 14-19 32452554-4 2020 In this study, we investigated the effects of EETs on the activation of nucleotide-binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3) inflammasome in murine macrophages. Leucine 98-105 NLR family, pyrin domain containing 3 Mus musculus 166-171 33178347-2 2020 Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation has been suggested to be a major cause of hepatocyte cell death in liver diseases. Leucine 43-50 NLR family, pyrin domain containing 3 Mus musculus 94-99 32947010-1 2020 Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to hepatic ischemia/reperfusion (I/R) injury, while the mechanism of how NLRP3 inflammasome is regulated remains less well defined. Leucine 40-47 NLR family, pyrin domain containing 3 Mus musculus 105-110 32947010-1 2020 Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to hepatic ischemia/reperfusion (I/R) injury, while the mechanism of how NLRP3 inflammasome is regulated remains less well defined. Leucine 40-47 NLR family, pyrin domain containing 3 Mus musculus 247-252 33093455-1 2020 Activation of the nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome plays an important role in ocular neovascularization. Leucine 44-51 NLR family, pyrin domain containing 3 Mus musculus 104-109 32385145-1 2020 BACKGROUND: We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome. Leucine 148-155 NLR family, pyrin domain containing 3 Mus musculus 137-142 33042624-2 2020 Although it is recognized that NLRP3 (nucleotide-binding domain, leucine-rich repeat-containing family, pyrin domain-containing 3) inflammasome is involved in pyroptosis activation, the mechanism by which head and neck squamous cell carcinoma (HNSCC) inhibits pyroptotic cell death remains undefined. Leucine 65-72 NLR family, pyrin domain containing 3 Mus musculus 31-36 32943500-3 2020 Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-mediated inflammasome assembly, caspase activation, and IL-1beta conversion occur at the microtubule-organizing center (MTOC). Leucine 46-53 NLR family, pyrin domain containing 3 Mus musculus 106-111 32476536-1 2020 Background Aberrant activation of the NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat-containing receptor family pyrin domain-containing 3) inflammasome is thought to play a causative role in atherosclerosis. Leucine 88-95 NLR family, pyrin domain containing 3 Mus musculus 38-43 32295623-7 2020 Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma. Leucine 57-64 NLR family, pyrin domain containing 3 Mus musculus 164-200 32295623-7 2020 Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma. Leucine 57-64 NLR family, pyrin domain containing 3 Mus musculus 202-207 29885849-3 2019 Emerging evidence indicates that the nucleotide-binding domain and leucine-rich-repeat-protein 3 (NLRP3) inflammasome-mediated neuroinflammation plays a crucial role in the pathogenesis of PD. Leucine 67-74 NLR family, pyrin domain containing 3 Mus musculus 98-103 31318658-7 2019 Foxp1 was further identified as a gatekeeper of vessel inflammation by direct regulation of endothelial inflammasome components, including Nlrp3 (NLR [nucleotide-binding and leucine-rich repeat immune receptors] family pyrin domain containing 3), caspase-1, and IL (interleukin)-1beta. Leucine 174-181 NLR family, pyrin domain containing 3 Mus musculus 139-144