PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9560319-4 1998 Mutation of this residue to Leu, Ile, Lys, Glu or Phe in the human GnRH receptor did not result in constitutive activity and instead led to complete uncoupling of the receptor (failure to support GnRH-stimulated inositol phosphate production). Leucine 28-31 gonadotropin releasing hormone 1 Homo sapiens 67-71 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Leucine 131-134 gonadotropin releasing hormone 1 Homo sapiens 42-46 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Leucine 131-134 gonadotropin releasing hormone 1 Homo sapiens 115-119 15967801-1 2005 The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH). Leucine 131-134 gonadotropin releasing hormone 1 Homo sapiens 115-119 12679482-8 2003 Our findings indicate that the juxtapositions between LHRH-IR and leu enkephalin-IR neurons may be functional synapses forming the morphological substrate of the leu-enkephalin-modulated LHRH secretion in the human diencephalon. Leucine 66-69 gonadotropin releasing hormone 1 Homo sapiens 187-191 10100886-1 1998 We have previously demonstrated that gonadotrophin-releasing hormone (GnRH) induces not only changes in quantity but also in quality on secreted luteinizing hormone (LH), by increasing [14C]Leu (translation) and [3H]Gal (distal glycosylation) incorporation into newly synthesized hormone. Leucine 190-193 gonadotropin releasing hormone 1 Homo sapiens 37-68 10100886-1 1998 We have previously demonstrated that gonadotrophin-releasing hormone (GnRH) induces not only changes in quantity but also in quality on secreted luteinizing hormone (LH), by increasing [14C]Leu (translation) and [3H]Gal (distal glycosylation) incorporation into newly synthesized hormone. Leucine 190-193 gonadotropin releasing hormone 1 Homo sapiens 70-74 10100886-6 1998 GnRH enhanced the rates of synthesis and release of [14C]Leu-, [3H]Man-, and [3H]Gal-LH to 157 and 237; 164 and 190; and 272 and 508% of basal values, respectively. Leucine 57-60 gonadotropin releasing hormone 1 Homo sapiens 0-4 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Leucine 81-84 gonadotropin releasing hormone 1 Homo sapiens 0-30 11255560-1 2000 Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes. Leucine 81-84 gonadotropin releasing hormone 1 Homo sapiens 32-36 8990079-9 1996 Comparatively, the effect of GnRH on [3H]Gal-LH was detected earlier than that on LH labeled with the other precursors; increases in rates of production (slope = 71.57; 278% of control) and release (slope = 32.08; 494%) were higher than those in [14C]Leu- and [3H]Man-LH kinetics, indicating that GnRH acts specifically on this distal step of LH glycosylation. Leucine 251-254 gonadotropin releasing hormone 1 Homo sapiens 29-33 8990079-10 1996 GnRH enhanced the relative terminal glycosylation ([3H]Gal/[14C]Leu ratio) of total and release LH without modifying the relative proximal glycosylation ([3H]Man/[14C]Leu ration) of the hormone. Leucine 64-67 gonadotropin releasing hormone 1 Homo sapiens 0-4 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Leucine 91-94 gonadotropin releasing hormone 1 Homo sapiens 27-57 8816823-5 1996 Tunicate GnRH-I (pGlu-His-Trp-Ser-Asp-Tyr-Phe-Lys-Pro-Gly-NH2) has 60% of its residues conserved, compared with mammalian GnRH, whereas tunicate GnRH-II (pGlu-His-Trp-Ser-Leu-Cys-His-Ala-Pro-Gly-NH2) is unusual in that it was isolated as a disulfide-linked dimer. Leucine 171-174 gonadotropin releasing hormone 1 Homo sapiens 9-13 7761629-7 1995 The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Leucine 69-72 gonadotropin releasing hormone 1 Homo sapiens 36-40 2556391-2 1989 Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH). Leucine 91-94 gonadotropin releasing hormone 1 Homo sapiens 59-63 6762537-5 1982 Analogs with non-aromatic or hydrophilic amino acids (X: Gly, Leu, Arg, His, Glu) in position 1 generally have much lower activities in this series of LH-RH antagonists. Leucine 62-65 gonadotropin releasing hormone 1 Homo sapiens 151-156 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Leucine 126-130 gonadotropin releasing hormone 1 Homo sapiens 55-92 2681686-1 1989 Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations. Leucine 126-130 gonadotropin releasing hormone 1 Homo sapiens 94-98 7050119-9 1982 These studies indicate that the structure of chicken hypothalamic LH-RH is: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2. Leucine 101-104 gonadotropin releasing hormone 1 Homo sapiens 66-71 31526925-0 2019 The mechanism of Oatp1a5-mediated microcystin-leucine arginine entering into GnRH neurons. Leucine 46-53 gonadotropin releasing hormone 1 Homo sapiens 77-81 7041967-1 1982 The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates. Leucine 178-181 gonadotropin releasing hormone 1 Homo sapiens 98-135 7041967-1 1982 The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates. Leucine 178-181 gonadotropin releasing hormone 1 Homo sapiens 137-142 31526925-1 2019 Microcystin-leucine arginine (MC-LR) enters into gonadotropin-releasing hormone (GnRH) neurons and induces decline of serum GnRH levels resulting in male reproductive toxicity via hypothalamic-pituitary-testis axis. Leucine 12-19 gonadotropin releasing hormone 1 Homo sapiens 49-79 31526925-1 2019 Microcystin-leucine arginine (MC-LR) enters into gonadotropin-releasing hormone (GnRH) neurons and induces decline of serum GnRH levels resulting in male reproductive toxicity via hypothalamic-pituitary-testis axis. Leucine 12-19 gonadotropin releasing hormone 1 Homo sapiens 81-85 31526925-1 2019 Microcystin-leucine arginine (MC-LR) enters into gonadotropin-releasing hormone (GnRH) neurons and induces decline of serum GnRH levels resulting in male reproductive toxicity via hypothalamic-pituitary-testis axis. Leucine 12-19 gonadotropin releasing hormone 1 Homo sapiens 124-128 25404067-1 2014 Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Leucine 254-257 gonadotropin releasing hormone 1 Homo sapiens 197-201