PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21062213-1 2011 The aim was to determine (a) Ala-16Val-SOD2 dimorphisms; (b) allelic frequency and phenotype of a common Pro-Leu polymorphism in GPx1, in a cohort of patients with a cardiogenic shock (CS) due to dilated cardiomyopathy without acute coronary syndrome. Leucine 109-112 glutathione peroxidase 1 Homo sapiens 129-133 22593803-4 2011 Twenty-four pairs of DNA samples, obtained from both whole-blood and adenoma tissue from the same individuals, were genotyped at 2 positions in the GPx-1 gene: a codon 198 variation resulting in either a leucine or proline at the corresponding position in the peptide, or a variable number of alanine repeat codons corresponding to the amino terminus of the GPx-1 protein. Leucine 204-211 glutathione peroxidase 1 Homo sapiens 148-153 19929244-7 2010 Combined MnSOD Ala/Ala and GPx1 Leu/Leu had a synergistic effect on HCC risk, with an OR of 3.84 (p = 0.029). Leucine 32-35 glutathione peroxidase 1 Homo sapiens 27-31 20578157-7 2010 The presence of two or more combined risk alleles (SOD2 Ala and GPX1 Leu) was more frequent in DILI patients (OR = 2.1; 95%CI = 1.4-3.0; Pc = 0.0006). Leucine 69-72 glutathione peroxidase 1 Homo sapiens 64-68 20578157-10 2010 CONCLUSION: Patients homozygous for the SOD2 Ala allele and the GPX1 Leu allele are at higher risk of developing cholestatic DILI. Leucine 69-72 glutathione peroxidase 1 Homo sapiens 64-68 19929244-7 2010 Combined MnSOD Ala/Ala and GPx1 Leu/Leu had a synergistic effect on HCC risk, with an OR of 3.84 (p = 0.029). Leucine 36-39 glutathione peroxidase 1 Homo sapiens 27-31 19415410-3 2009 The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. Leucine 100-103 glutathione peroxidase 1 Homo sapiens 28-32 19415410-3 2009 The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. Leucine 91-98 glutathione peroxidase 1 Homo sapiens 48-52 20480816-3 2010 Occurrence of genotypes Ile/ Val of GSTP1 gene, Pro/Leu in GPX1 gene in the main group were lower vs. that in the reference one. Leucine 52-55 glutathione peroxidase 1 Homo sapiens 59-63 19415410-3 2009 The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. Leucine 91-98 glutathione peroxidase 1 Homo sapiens 28-32 19415410-3 2009 The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the proline (Pro) to leucine (Leu) change at codon 198 is supposed to be functional. Leucine 100-103 glutathione peroxidase 1 Homo sapiens 48-52 19415410-5 2009 Some authors observed a decrease in GPx1 activity associated with GPx1 Leu allele in humans; however, there were no findings on how GPx1 activity changes with Se concentration in individuals with different GPx1 genotypes. Leucine 71-74 glutathione peroxidase 1 Homo sapiens 36-40 19415410-5 2009 Some authors observed a decrease in GPx1 activity associated with GPx1 Leu allele in humans; however, there were no findings on how GPx1 activity changes with Se concentration in individuals with different GPx1 genotypes. Leucine 71-74 glutathione peroxidase 1 Homo sapiens 66-70 19415410-5 2009 Some authors observed a decrease in GPx1 activity associated with GPx1 Leu allele in humans; however, there were no findings on how GPx1 activity changes with Se concentration in individuals with different GPx1 genotypes. Leucine 71-74 glutathione peroxidase 1 Homo sapiens 66-70 19415410-5 2009 Some authors observed a decrease in GPx1 activity associated with GPx1 Leu allele in humans; however, there were no findings on how GPx1 activity changes with Se concentration in individuals with different GPx1 genotypes. Leucine 71-74 glutathione peroxidase 1 Homo sapiens 66-70 18563616-5 2009 We found an overall protective effect of the variant Leu allele of the GPX1 polymorphism on the prostate cancer risk. Leucine 53-56 glutathione peroxidase 1 Homo sapiens 71-75 19428376-7 2009 We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1(198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95% CI: 1.17-1.81, P=0.02) per 10g alcohol intake per day and 2.56 (95% CI: 0.99-6.61, P=0.02) among ever smokers compared with never smokers at enrolment. Leucine 100-103 glutathione peroxidase 1 Homo sapiens 91-95 19035188-1 2008 OBJECTIVE: This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development. Leucine 83-86 glutathione peroxidase 1 Homo sapiens 64-68 18541150-2 2008 The 198Pro/leu variant, located at codon 198 of GPX1 gene, has recently been linked to cardiovascular disease, but data were inconsistent. Leucine 11-14 glutathione peroxidase 1 Homo sapiens 48-52 18541150-9 2008 CONCLUSION: These data provide evidence that GPX1 198Pro/leu variant genotypes are significantly associated with CAD risk in this Chinese population. Leucine 57-60 glutathione peroxidase 1 Homo sapiens 45-49 16615267-10 2006 Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR = 2.29). Leucine 36-39 glutathione peroxidase 1 Homo sapiens 56-60 16615267-10 2006 Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR = 2.29). Leucine 29-32 glutathione peroxidase 1 Homo sapiens 56-60 16615267-10 2006 Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR = 2.29). Leucine 36-39 glutathione peroxidase 1 Homo sapiens 56-60 16615267-13 2006 CONCLUSIONS: These results lead to a conclusion that individuals with the GPX1 Pro/Leu or Leu/Leu genotype would be more susceptible to the lung cancer induced by oxidative stress than those individuals with the Pro/Pro genotype. Leucine 83-86 glutathione peroxidase 1 Homo sapiens 74-78 16413612-8 2006 A proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) in the GPX1 gene was genotyped. Leucine 19-26 glutathione peroxidase 1 Homo sapiens 78-82 16413612-8 2006 A proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) in the GPX1 gene was genotyped. Leucine 28-31 glutathione peroxidase 1 Homo sapiens 78-82 12810669-2 2003 By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the proline-containing allele (odds ratio = 1.9; P < 0.05). Leucine 82-89 glutathione peroxidase 1 Homo sapiens 56-61 15318035-4 2004 The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia. Leucine 102-109 glutathione peroxidase 1 Homo sapiens 167-171 15318035-4 2004 The aim of this study is to examine whether a potentially functional polymorphism, a proline (Pro) to leucine (Leu) substitution at codon 197 (Pro197Leu) of the human GPX1 gene, is associated with susceptibility to schizophrenia. Leucine 111-114 glutathione peroxidase 1 Homo sapiens 167-171 15247771-3 2004 MATERIALS AND METHODS: Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the isoleucine to threonine polymorphism at codon 56 of MnSOD were determined by a polymerase chain reaction-restriction fragment length polymorphism technique in 213 patients and 209 normal controls. Leucine 40-47 glutathione peroxidase 1 Homo sapiens 100-104 15247771-3 2004 MATERIALS AND METHODS: Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the isoleucine to threonine polymorphism at codon 56 of MnSOD were determined by a polymerase chain reaction-restriction fragment length polymorphism technique in 213 patients and 209 normal controls. Leucine 49-52 glutathione peroxidase 1 Homo sapiens 100-104 15247771-9 2004 CONCLUSIONS: The GPX1 Pro/Leu genotype may significantly increase the risk of bladder cancer and the increased risk may be modified by the Ala-9Val MnSOD polymorphism. Leucine 26-29 glutathione peroxidase 1 Homo sapiens 17-21 12810669-2 2003 By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the proline-containing allele (odds ratio = 1.9; P < 0.05). Leucine 142-149 glutathione peroxidase 1 Homo sapiens 56-61 26446998-10 2015 RESULTS: Breast cancer risk was significantly associated with GPX1 rs1050450 (Pro198Leu) polymorphism, showing a protective effect of variant (Leu) allele. Leucine 84-87 glutathione peroxidase 1 Homo sapiens 62-66 30206965-7 2018 Distribution of alleles among patients suffering from PCOS versus healthy women was "Pro" (69.1% vs 68.8%) and "Leu" (31.4% vs 31.2%) for Gpx1, "Ala" (61.43% vs 56.57%) and "Val" (38.57% vs 43.43%) for MnSOD, and "C" (83.43% vs 84.57%) and "T" (16.57% vs 15.43%) for CAT. Leucine 112-115 glutathione peroxidase 1 Homo sapiens 138-142 8001233-8 1994 However, sequence analysis did reveal that the three GPX1 alleles were characterized by three nucleotide substitutions in addition to the polyalanine polymorphism, including a substitution at codon 198 which results in either a proline or leucine at that position. Leucine 239-246 glutathione peroxidase 1 Homo sapiens 53-57 30394058-2 2019 Two common variations have been focused upon, one resulting in leucine or proline at codon 198 and another resulting in 5, 6, or 7 alanine repeats were previously shown to affect the distribution of GPX1 between the cytoplasm and mitochondria. Leucine 63-70 glutathione peroxidase 1 Homo sapiens 199-203 24887198-10 2014 The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. Leucine 31-34 glutathione peroxidase 1 Homo sapiens 20-24 25606455-1 2014 BACKGROUND: We studied the association between erythrocyte glutathione peroxidase1 (GPx1) activity and rs1050450 (Pro198Leu) site with the stenosis of coronary arteries and, evaluated the Pro/Leu position within the predicted tertiary structure. Leucine 120-123 glutathione peroxidase 1 Homo sapiens 59-82 25606455-1 2014 BACKGROUND: We studied the association between erythrocyte glutathione peroxidase1 (GPx1) activity and rs1050450 (Pro198Leu) site with the stenosis of coronary arteries and, evaluated the Pro/Leu position within the predicted tertiary structure. Leucine 120-123 glutathione peroxidase 1 Homo sapiens 84-88 25033027-4 2014 A functional polymorphism at codon 198 of the GPX1 gene causes a C/T substitution in exon 2, which encodes for either proline or leucine (Pro198Leu). Leucine 129-136 glutathione peroxidase 1 Homo sapiens 46-50 24887198-10 2014 The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. Leucine 86-89 glutathione peroxidase 1 Homo sapiens 20-24 24887198-10 2014 The frequencies for GPx1 Pro198Leu polymorphism were 55%, 38% and 7% for Pro/Pro, Pro/Leu and Leu/Leu, respectively. Leucine 86-89 glutathione peroxidase 1 Homo sapiens 20-24 24039907-7 2013 Additionally, Leu carriers for GPX1 Pro198Leu polymorphism (rs1050450) were at ~2 fold increased risk of developing a non-ductal BC. Leucine 14-17 glutathione peroxidase 1 Homo sapiens 31-35 21904836-7 2012 Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. Leucine 58-61 glutathione peroxidase 1 Homo sapiens 69-73 21904836-7 2012 Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. Leucine 62-65 glutathione peroxidase 1 Homo sapiens 69-73 21904836-9 2012 In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk. Leucine 59-62 glutathione peroxidase 1 Homo sapiens 54-58 21904836-9 2012 In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk. Leucine 63-66 glutathione peroxidase 1 Homo sapiens 54-58