PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30071532-8	2018	SLC1A5 knockdown with siRNA (PZ siRNA) in TE-1 cells in vitro significantly decreased cell growth and reduced both leucine and glutamine transport, leading to inhibition of mTORC1 signaling.	Leucine	115-122	solute carrier family 1 member 5	Homo sapiens	0-6	
30029480-7	2018	However, intracellular accumulation of radiolabeled glutamine and leucine over longer time periods largely recovered to control levels in ASCT2 and LAT1 knockout cells, respectively, which partially explains the lack of an impaired growth phenotype.	Leucine	66-73	solute carrier family 1 member 5	Homo sapiens	138-143	
29940911-2	2018	In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore targeting the primary cell-surface transporters that mediate their uptake, L-type amino acid transporter 1 (LAT1) and alanine, serine, cysteine-preferring transporter 2 (ASCT2), is a potential therapeutic strategy.	Leucine	15-22	solute carrier family 1 member 5	Homo sapiens	306-311	
29940911-3	2018	METHODS: The ASCT2 inhibitor, benzylserine (BenSer), is also able to block LAT1 activity, thus inhibiting both leucine and glutamine uptake.	Leucine	111-118	solute carrier family 1 member 5	Homo sapiens	13-18	
28091567-6	2017	Furthermore, Leu and Phe uptake by heterologously expressed human SLC6A14/ATB0,+ and SLC43A2/LAT4 was accurately calculated.	Leucine	13-16	solute carrier family 1 member 5	Homo sapiens	74-78	
24531984-6	2014	While inhibition of LAT1 by BCH did not suppress melanoma cell growth, the ASCT2 inhibitor BenSer significantly reduced both leucine and glutamine transport in melanoma cells, leading to inhibition of mTORC1 signaling.	Leucine	125-132	solute carrier family 1 member 5	Homo sapiens	75-80	
33953707-7	2021	In particular, the amino acid transporters SLC1A5 and SLC7A5 as well as the ancillary subunit SLC3A2, which are required for efficient uptake of glutamine and leucine respectively, could strengthen the metabolic capabilities and effector functions of tumor-directed CAR-NK and T cells.	Leucine	159-166	solute carrier family 1 member 5	Homo sapiens	43-49	
33841424-5	2021	In addition, flagellin upregulated the amount of other amino acids substrates of ATB0,+, in particular, all the essential amino acids, such as valine, isoleucine, and leucine, along with the non-essential glutamine.	Leucine	154-161	solute carrier family 1 member 5	Homo sapiens	81-85