PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15334500-0 2004 Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1. Leucine 97-104 NLR family pyrin domain containing 3 Homo sapiens 127-132 11687797-7 2001 This gene, called CIAS1, is expressed in peripheral blood leukocytes and encodes a protein with a pyrin domain, a nucleotide-binding site (NBS, NACHT subfamily) domain and a leucine-rich repeat (LRR) motif region, suggesting a role in the regulation of inflammation and apoptosis. Leucine 174-181 NLR family pyrin domain containing 3 Homo sapiens 18-23 34628106-2 2021 Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome mechanisms ((a protein complex of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1)) have been reported to play roles in controlling placental inflammation involved in pregnancy pathologies. Leucine 57-64 NLR family pyrin domain containing 3 Homo sapiens 164-169 34600073-5 2021 And, it was found that Parkin could exert neuroprotective effects on RGCs by inhibiting nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome. Leucine 114-121 NLR family pyrin domain containing 3 Homo sapiens 179-184 34867921-1 2021 Nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome-mediated interleukin-1 beta (IL-1beta) production is one of the crucial responses in innate immunity upon infection with viruses including influenza A virus (IAV) and is modulated by both viral and host cellular proteins. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 72-77 34536551-4 2021 Nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome, whose activation and assembly significantly affect the release of IL-1beta, is a crucial effector activated by a variety of metabolites. Leucine 46-53 NLR family pyrin domain containing 3 Homo sapiens 82-87 34951208-6 2021 In autoimmune diseases, NETs as important sources of autoantigens, can act as danger-associated molecular patterns( DAMPs) and activate the nucleotide-binding oligomerization domain leucine-rich repeats containing pyrin domain 3(NLRP3) inflammasome and complement system, thereby breaking self-tolerance and accelerating autoimmune inflammation. Leucine 182-189 NLR family pyrin domain containing 3 Homo sapiens 229-234 34172780-1 2021 Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 85-90 34671876-3 2022 Here, we present a patient with a rare leucine-rich repeat (LRR) domain mutation, p.Arg920Gln (p.R920Q), associated with an atypical NLRP3-AID with recurrent episodes of sore throat and extensive oropharyngeal ulceration. Leucine 39-46 NLR family pyrin domain containing 3 Homo sapiens 133-138 34350135-4 2021 Much research has focused on toll-like receptors and more recently the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 (NLRP3) inflammasome, which is required for the processing and release of IL-1beta. Leucine 101-108 NLR family pyrin domain containing 3 Homo sapiens 149-154 34313166-1 2022 We investigated the effects of the NACHT leucine-rich repeat- and PYD-containing proteins (NLRP3) inflammasome, interleukin -18 (IL-18) and interleukin-1 beta (IL-1beta) cytokines on the expression of filaggrin-2 (FLG-2) protein in psoriasis patients. Leucine 41-48 NLR family pyrin domain containing 3 Homo sapiens 91-96 34599390-3 2021 RECENT FINDINGS: Recently, it has been shown that the activation of the NLRP3 (NACHT, leucine-rich repeat, and pyrin domain-containing protein 3) inflammasome is central in the pathophysiology of pericarditis. Leucine 86-93 NLR family pyrin domain containing 3 Homo sapiens 72-77 34467562-5 2022 Recently, increasing evidence highlights the NLRP3 (NOD-like, leucine-rich repeat domains, and pyrin domain-containing protein) inflammasome complex along with IL-1beta and effete neutrophils producing neutrophil extracellular traps (NETs) through NETosis. Leucine 62-69 NLR family pyrin domain containing 3 Homo sapiens 45-50 34381452-1 2021 The nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor protein 3 (NLRP3) is an important pattern recognition receptor in human innate immunity. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 98-103 34172780-1 2021 Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 162-167 35612721-3 2022 RECENT FINDINGS: The latest research on this topic has focused on the critical role of the NLRP3 (NACHT, leucine-rich repeat, and pyrin domain-containing protein) inflammasome. Leucine 105-112 NLR family pyrin domain containing 3 Homo sapiens 91-96 35631400-3 2022 Here, we demonstrate the role of the host nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing 3 (NLRP3) inflammasome in metastatic breast cancer. Leucine 69-76 NLR family pyrin domain containing 3 Homo sapiens 128-133 33901504-4 2021 The nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is the best understood in terms of molecular mechanisms, and is a promising therapeutic target in immune-related disorders. Leucine 46-53 NLR family pyrin domain containing 3 Homo sapiens 97-102 35513901-1 2022 The nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome has emerged as a key mediator of pathological inflammation in many diseases and is an exciting drug target. Leucine 47-54 NLR family pyrin domain containing 3 Homo sapiens 106-111 35441575-8 2022 Nucleotide-binding domain leucine-rich repeat family protein 3 (NLRP3) inflammasome activation is vital for cell pyroptosis, and FTO functions as a pivotal modulator in the N6-methyladenosine modifications of various genes. Leucine 26-33 NLR family pyrin domain containing 3 Homo sapiens 64-69 35022530-1 2022 In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Leucine 66-73 NLR family pyrin domain containing 3 Homo sapiens 125-130 35081900-5 2022 One of the most important tasks remains in the ATPase nucleotide-binding oligomerization domain nucleotide-binding domain leucine-rich repeat-containing receptors protein 3 (NLRP3), in which the blocking of its oligomerization is related to the functional inhibition of inflammasomes. Leucine 122-129 NLR family pyrin domain containing 3 Homo sapiens 174-179 35237974-5 2022 Importantly, activation of the nucleotide oligomerization domain leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome activates the caspase-1 protease and results in the generation and release of potent pro-inflammatory cytokines, IL-1beta and IL-18. Leucine 65-72 NLR family pyrin domain containing 3 Homo sapiens 124-129 35559886-2 2022 More and more research has indicated that fine particulate matter (PM2.5) plays a critical role in causing pulmonary inflammation or fibrosis, which potentially is ascribed to the activation of nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. Leucine 224-231 NLR family pyrin domain containing 3 Homo sapiens 255-260 34059091-4 2021 The NLRP3 inflammasome is a complex with multiple components, including an NAIP, CIITA, HET-E, and TP1 (NACHT) domain; apoptosis-associated speck-like protein containing a CARD (ASC); and a leucine-rich repeat (LRR) domain. Leucine 190-197 NLR family pyrin domain containing 3 Homo sapiens 4-9 34058500-4 2021 Insoluble La(III) species could adhere to extracellular membrane or be internalized into cells, capable of activating a nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome. Leucine 150-157 NLR family pyrin domain containing 3 Homo sapiens 181-186 35412034-3 2022 The NLRP3 (NACHT, leucine-rich repeat, and pyrin domain-containing protein 3) inflammasome is a protein complex that functions as a platform for rapid induction of the inflammatory response to infection or sterile injury through pro-inflammatory cytokines, now recognized as a new important therapeutic target for myopericardial diseases. Leucine 18-25 NLR family pyrin domain containing 3 Homo sapiens 4-9 35047512-3 2021 NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3), a tripartite protein, contains three functional domains a central nucleotide-binding and oligomerization domain (NACHT), an N-terminal pyrin domain (PYD), and a leucine-rich repeat domain (LRR). Leucine 228-235 NLR family pyrin domain containing 3 Homo sapiens 0-57 35047512-3 2021 NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3), a tripartite protein, contains three functional domains a central nucleotide-binding and oligomerization domain (NACHT), an N-terminal pyrin domain (PYD), and a leucine-rich repeat domain (LRR). Leucine 228-235 NLR family pyrin domain containing 3 Homo sapiens 59-64 34059097-1 2021 BACKGROUND: Cryopyrin-associated periodic syndrome (CAPS) is a life-long, autoinflammatory disease associated with a gain-of-function mutation in the nucleotide-binding domain, leucine-rich repeat family, pyrin domain containing 3 (NLRP3) gene, which result in uncontrolled production of IL-1beta and chronic inflammation. Leucine 177-184 NLR family pyrin domain containing 3 Homo sapiens 12-21 34059097-1 2021 BACKGROUND: Cryopyrin-associated periodic syndrome (CAPS) is a life-long, autoinflammatory disease associated with a gain-of-function mutation in the nucleotide-binding domain, leucine-rich repeat family, pyrin domain containing 3 (NLRP3) gene, which result in uncontrolled production of IL-1beta and chronic inflammation. Leucine 177-184 NLR family pyrin domain containing 3 Homo sapiens 232-237 33673188-2 2021 The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome is a protein complex that functions as a platform for rapid induction of the inflammatory response to infection or sterile injury. Leucine 11-18 NLR family pyrin domain containing 3 Homo sapiens 83-88 33781745-3 2021 Previous work has demonstrated that inhibiting the ATPase activity of the Nucleotide-Binding Oligomerization Domain, Leucine-Rich Repeat and Pyrin Domain (NLR) containing protein 3 (NLRP3) disrupts inflammasome assembly and function. Leucine 117-124 NLR family pyrin domain containing 3 Homo sapiens 182-187 32531835-2 2021 Distinctiveness of the nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome resides in the diversity of molecules that induce its activation, indicating a certain intricacy. Leucine 65-72 NLR family pyrin domain containing 3 Homo sapiens 111-116 33636340-3 2021 The nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome is the most well characterised inflammasome, and its aberrant activation is implicated in many inflammatory diseases. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 90-95 32667050-3 2020 NLRP3 (Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Leucine 33-40 NLR family pyrin domain containing 3 Homo sapiens 0-5 33500734-8 2021 Moreover, PPARgamma interfered with NLRP3 inflammasome formation by decreasing NLRP3-ASC and NLRP3-NLRP3 interactions as well as NLRP3-dependent ASC oligomerization, which is mediated through interaction between the PPARgamma DNA-binding domain and the nucleotide-binding and leucine-rich repeat domains of NLRP3. Leucine 276-283 NLR family pyrin domain containing 3 Homo sapiens 36-41 33337127-3 2021 In particular, pre-clinical and clinical studies have contributed to increasing our knowledge on the role of interleukin (IL)-1 and NLRP3 (NACHT, leucine- rich repeat, and pyrin domain- containing protein 3) inflammasome. Leucine 146-153 NLR family pyrin domain containing 3 Homo sapiens 132-137 33330501-4 2020 In conjunction with key binding partners Leucine rich repeat in the Flightless I interaction proteins (LRRFIP)1/2, Flightless I acts both synergistically and competitively to regulate a wide range of cellular signaling including interacting with two of the most important inflammatory pathways, the NLRP3 inflammasome and the MyD88-TLR4 pathways. Leucine 41-48 NLR family pyrin domain containing 3 Homo sapiens 299-304 33435142-1 2021 NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). Leucine 96-103 NLR family pyrin domain containing 3 Homo sapiens 0-5 32505910-5 2020 IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta. Leucine 87-94 NLR family pyrin domain containing 3 Homo sapiens 70-75 33117011-3 2020 The role of nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome in inducing activation of inflammatory signaling in IOSSD is not clear. Leucine 42-49 NLR family pyrin domain containing 3 Homo sapiens 73-78 33014529-5 2020 This review summarizes the molecular mechanisms of pyroptosis and shows the critical role of NLRP3 (NLR family, pyrin domain containing 3; NLR refers to "nucleotide-binding domain, leucine-rich repeat") inflammasomes. Leucine 181-188 NLR family pyrin domain containing 3 Homo sapiens 93-98 33014529-5 2020 This review summarizes the molecular mechanisms of pyroptosis and shows the critical role of NLRP3 (NLR family, pyrin domain containing 3; NLR refers to "nucleotide-binding domain, leucine-rich repeat") inflammasomes. Leucine 181-188 NLR family pyrin domain containing 3 Homo sapiens 100-137 32505910-5 2020 IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta. Leucine 87-94 NLR family pyrin domain containing 3 Homo sapiens 179-184 32615411-2 2020 During the formation of inflammatory conditions, the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome activation plays an important regulator. Leucine 83-90 NLR family pyrin domain containing 3 Homo sapiens 114-119 32473843-3 2020 Of note, the nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome acts as a key player in both coordinating the host physiology and shaping the peripheral and central immune/inflammatory responses in CNS diseases. Leucine 55-62 NLR family pyrin domain containing 3 Homo sapiens 114-119 32390276-3 2020 Compelling evidence has indicated the activation of the nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome, a cytoplasmic complex containing multiple proteins, in a variety of lipid-related diseases including obesity, atherosclerosis, liver diseases, and type 2 diabetes. Leucine 117-124 NLR family pyrin domain containing 3 Homo sapiens 168-173 32854254-7 2020 Our studies revealed that RSV induces lytic cell death in macrophages via both of these mechanisms, specifically through the ASC (Apoptosis-associated speck like protein containing a caspase recruitment domain)-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome activation of both caspase-1 dependent pyroptosis and receptor-interacting serine/threonine-protein kinase 3 (RIPK3), as well as a mixed lineage kinase domain like pseudokinase (MLKL)-dependent necroptosis. Leucine 245-252 NLR family pyrin domain containing 3 Homo sapiens 211-216 32765715-5 2020 Nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome has been studied predominantly and several hypotheses have been issued. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 61-66 32529290-5 2020 However, the identification of MS patients harboring rare homozygote variants in NLRP1 (p.Ile601Phe and p.Ser1387Ile), a variant in NLRP3 (p.Leu832Ile) resulting in the substitution of a critical amino acid for the formation of its leucine-rich repeat domain, and several MS patients with NLRC4 variants (p.Arg310Ter and p.Glu600Ter) causing protein truncations suggest that rare protein-altering variants in inflammasome-activating NLR receptors may contribute to MS risk. Leucine 232-239 NLR family pyrin domain containing 3 Homo sapiens 132-137 32751530-2 2020 As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome can be activated by various endogenous and exogenous danger signals. Leucine 104-111 NLR family pyrin domain containing 3 Homo sapiens 156-161 32423023-1 2020 The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense. Leucine 38-45 NLR family pyrin domain containing 3 Homo sapiens 4-9 32792920-4 2020 The nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome, which is one of the most intensively investigated inflammasomes, has been reported to play a key role in neurodegenerative diseases. Leucine 46-53 NLR family pyrin domain containing 3 Homo sapiens 105-110 32765942-3 2020 Recent studies suggest a role for the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome activation in lung inflammation and fibrosis in SARS-CoV and SARS-CoV-2 infections. Leucine 68-75 NLR family pyrin domain containing 3 Homo sapiens 134-139 32323100-2 2020 In the progression of AP, the function of nucleotide-binding oligomerization, leucine-rich repeat and pyrin domain domains-containing protein 3 (NLRP3) inflammasome has been revealed. Leucine 78-85 NLR family pyrin domain containing 3 Homo sapiens 145-150 32450899-15 2020 Uncoupled hemichannels permit the release of adenosine triphosphate (ATP) in to the extracellular space ( [ATP]e), where ATP binds to the P2X7 purinoreceptor and activates the nucleotide-binding domain and leucine-rich repeat containing (NLR) protein-3 (NLRP3) inflammasome. Leucine 206-213 NLR family pyrin domain containing 3 Homo sapiens 254-259 32296327-1 2020 Aim: To investigate the role of histone deacetylase 6 (HDAC6) deacetylation activity in nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammatory response and explore the effects of pharmacological inhibition of HDAC6 with tubastatin A (TBA) on dopaminergic injury. Leucine 134-141 NLR family pyrin domain containing 3 Homo sapiens 170-175 31999304-5 2020 Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. Leucine 62-69 NLR family pyrin domain containing 3 Homo sapiens 56-61 32282893-6 2020 Functional experiments at baseline measuring apoptosis-associated speck-like protein containing a CARD (ASC) speck formation showed that the NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome was overactive in monocytes from patients with primary progressive multiple sclerosis, and canonical NLRP3 inflammasome activation with a combination of ATP plus lipopolysaccharide was associated with increased IL1B production in this group of patients. Leucine 145-152 NLR family pyrin domain containing 3 Homo sapiens 197-202 32282893-6 2020 Functional experiments at baseline measuring apoptosis-associated speck-like protein containing a CARD (ASC) speck formation showed that the NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome was overactive in monocytes from patients with primary progressive multiple sclerosis, and canonical NLRP3 inflammasome activation with a combination of ATP plus lipopolysaccharide was associated with increased IL1B production in this group of patients. Leucine 145-152 NLR family pyrin domain containing 3 Homo sapiens 318-323 31749805-2 2019 By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3), ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), and procaspase-1. Leucine 135-142 NLR family pyrin domain containing 3 Homo sapiens 64-69 31941382-0 2020 Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-kappaB (Nuclear Factor kappaB) Signals. Leucine 111-118 NLR family pyrin domain containing 3 Homo sapiens 77-82 31941382-10 2020 Interestingly, TMAO activated NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-kappaB (nuclear factor kappaB) signals during vascular calcification. Leucine 64-71 NLR family pyrin domain containing 3 Homo sapiens 30-35 31593687-2 2019 The nucleotide-binding oligomerization domain, leucine-rich repeat-containing receptor-containing pyrin domain 3 (NLRP3) inflammasome and pyroptosis play crucial roles in the progression of NASH. Leucine 47-54 NLR family pyrin domain containing 3 Homo sapiens 114-119 32363817-1 2020 BACKGROUND AND OBJECTIVE: Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) plays a pivotal role in initiation of inflammation. Leucine 53-60 NLR family pyrin domain containing 3 Homo sapiens 112-117 31749805-2 2019 By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3), ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), and procaspase-1. Leucine 135-142 NLR family pyrin domain containing 3 Homo sapiens 102-107 31231549-8 2019 Mechanistically, ORF8b interacts directly with the Leucine Rich Repeat domain of NLRP3 and localizes with NLRP3 and ASC in cytosolic dot-like structures. Leucine 51-58 NLR family pyrin domain containing 3 Homo sapiens 81-86 31302424-3 2019 Nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) inflammasome as a multi-protein complex that activates caspase-1 can give rise to the proinflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) maturation. Leucine 30-37 NLR family pyrin domain containing 3 Homo sapiens 77-82 30776150-7 2019 Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response. Leucine 27-34 NLR family pyrin domain containing 3 Homo sapiens 86-91 31038962-1 2019 The nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome is a key regulator of innate immune responses, and its aberrant activation is implicated in the pathogenesis of many diseases such as Alzheimer"s disease and type 2 diabetes. Leucine 34-41 NLR family pyrin domain containing 3 Homo sapiens 100-105 31189953-4 2019 The earring-shaped NLRP3 consists of curved leucine-rich-repeat and globular NACHT domains, and the C-terminal lobe of NEK7 nestles against both NLRP3 domains. Leucine 44-51 NLR family pyrin domain containing 3 Homo sapiens 19-24 30653357-1 2019 Activation of the NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome plays a key role in host immune response, which is the first line of defense against cellular stresses and pathogen infections. Leucine 25-32 NLR family pyrin domain containing 3 Homo sapiens 108-113 30776150-7 2019 Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response. Leucine 27-34 NLR family pyrin domain containing 3 Homo sapiens 187-192 30776150-7 2019 Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) was shown to be involved in the IL-1beta response of liver macrophages to HIV-1 infection and NLRP3 blocking experiments in primary CD68+ liver macrophages confirmed the contribution of the NLRP3-caspase 1 inflammatory signaling pathway in the IL-1beta response. Leucine 27-34 NLR family pyrin domain containing 3 Homo sapiens 187-192 30594776-3 2019 The nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is an inflammatory complex existing in microglia. Leucine 48-55 NLR family pyrin domain containing 3 Homo sapiens 99-104 30873162-3 2019 The C-terminal conserves a leucine-rich repeats (LRRs) domain which can modulate NLRP3 activity and sense endogenous alarmins and microbial ligands. Leucine 27-34 NLR family pyrin domain containing 3 Homo sapiens 81-86 23512739-1 2013 The NLRP3 inflammasome, which consists of the NLRP3 (nucleotide-binding oligomerization domain (Nod)-like receptor 3) scaffold, the ASC (apoptosis-associated speck-like protein containing a CARD) adaptor and procaspase- 1, is assembled after the cytoplasmic LRRs (leucine-rich repeats) of NLRP3 sense pathogens or danger signals. Leucine 264-271 NLR family pyrin domain containing 3 Homo sapiens 4-9 27314526-4 2016 Best characterized in microbial pathogenesis is the nucleotide-binding domain and leucine-rich repeat (NLR)-protein 3 (NLRP3) inflammasome. Leucine 82-89 NLR family pyrin domain containing 3 Homo sapiens 119-124 30591286-11 2019 Recent demonstration that cholesterol crystals trigger the NLRP3 (nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3) inflammasome and the release of inflammatory cytokines that also drive uric acid crystal-induced inflammation indicates that the multiple actions of colchicine that make it effective in gout may be relevant to preventing inflammation and limiting inflammatory injury in atherosclerosis. Leucine 102-109 NLR family pyrin domain containing 3 Homo sapiens 59-64 30295793-3 2018 The nucleotide-binding domain, leucine-rich repeats-containing family, pyrin domain-containing-3 (NLRP3) inflammasome complex, comprising NLRP3, apoptotic speck protein containing a caspase recruitment domain (ASC), and cysteine aspartic acid protease 1 (Caspase 1), regulates microglial inflammation in several neurodegenerative diseases. Leucine 31-38 NLR family pyrin domain containing 3 Homo sapiens 98-103