PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33684397-8 2021 The binding mode of the drugs with M-protein was analyzed and it was observed that Colchicine, Remdesivir, Bafilomycin A1 from COVID-19 suggested drugs and Temozolomide from SuperDRUG2 database displayed desirable molecular interactions and higher binding affinity towards M-protein. Colchicine 83-93 myomesin 2 Homo sapiens 35-44 33684397-8 2021 The binding mode of the drugs with M-protein was analyzed and it was observed that Colchicine, Remdesivir, Bafilomycin A1 from COVID-19 suggested drugs and Temozolomide from SuperDRUG2 database displayed desirable molecular interactions and higher binding affinity towards M-protein. Colchicine 83-93 myomesin 2 Homo sapiens 273-282 33684397-9 2021 Interestingly, Colchicine was found as the top most binder among tested drugs against M-protein. Colchicine 15-25 myomesin 2 Homo sapiens 86-95 33684397-10 2021 We therefore additionally identified four Colchicine derivatives which can bind efficiently with M-protein and have better pharmacokinetic properties. Colchicine 42-52 myomesin 2 Homo sapiens 97-106