PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27450182-8	2016	In human liver microsomal (HLM) incubations, CYP3A4-selective inhibitors SR-9186 and CYP3cide reduced formation of GSH adducts by 78% and 72%, respectively, compared with >90% inhibition by the pan-CYP3A inhibitor ketoconazole.	1-(4-imidazopyridinyl-7-phenyl)-3-(4'-cyanobiphenyl)urea	73-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51	
27450182-8	2016	In human liver microsomal (HLM) incubations, CYP3A4-selective inhibitors SR-9186 and CYP3cide reduced formation of GSH adducts by 78% and 72%, respectively, compared with >90% inhibition by the pan-CYP3A inhibitor ketoconazole.	1-(4-imidazopyridinyl-7-phenyl)-3-(4'-cyanobiphenyl)urea	73-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-50	
22696420-3	2012	1-(4-Imidazopyridinyl-7phenyl)-3-(4"-cyanobiphenyl) urea (SR-9186) was optimized through several rounds of structural refinement from an initial screening hit to obtain greater than 1000-fold selectivity for the inhibition of CYP3A4 versus CYP3A5.	1-(4-imidazopyridinyl-7-phenyl)-3-(4'-cyanobiphenyl)urea	0-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	226-232