PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29233996-5	2017	However, the PEPD-p53 complex is critical for p53 response to stress, as stress signals doxorubicin and H2O2 each must free p53 from PEPD in order to achieve robust p53 activation, which is mediated by reactive oxygen species.	Doxorubicin	88-99	peptidase D	Homo sapiens	13-17	
29233996-5	2017	However, the PEPD-p53 complex is critical for p53 response to stress, as stress signals doxorubicin and H2O2 each must free p53 from PEPD in order to achieve robust p53 activation, which is mediated by reactive oxygen species.	Doxorubicin	88-99	peptidase D	Homo sapiens	133-137	
11137854-5	2001	Therefore, we compared the effect of daunorubicin and doxorubicin on prolidase activity and collagen biosynthesis in confluent cultured human skin fibroblasts.	Doxorubicin	54-65	peptidase D	Homo sapiens	69-78	
11137854-6	2001	We have found that daunorubicin and doxorubicin coordinately induced the inhibition of prolidase activity (IC(50)=0.3 and 10 microM, respectively) and collagen biosynthesis (IC(50)=1 and 15 microM, respectively) in cultured human skin fibroblasts.	Doxorubicin	36-47	peptidase D	Homo sapiens	87-96	
11137854-7	2001	The inhibitory effect of daunorubicin or doxorubicin on prolidase activity and collagen biosynthesis was not due to anti-proliferative activity of these drugs as shown by cell viability tetrazoline test.	Doxorubicin	41-52	peptidase D	Homo sapiens	56-65	
11137854-15	2001	The higher ability of daunorubicin vs. doxorubicin to chelate manganese and inhibit prolidase activity may explain the potential mechanism for its greater potency to inhibit collagen biosynthesis.	Doxorubicin	39-50	peptidase D	Homo sapiens	84-93	
9798267-0	1998	Doxorubicin-induced inhibition of prolidase activity in human skin fibroblasts and its implication to impaired collagen biosynthesis.	Doxorubicin	0-11	peptidase D	Homo sapiens	34-43	
9798267-3	1998	We considered prolidase, an enzyme involved in collagen metabolism as a possible target for doxorubicin-induced inhibition of synthesis of this protein.	Doxorubicin	92-103	peptidase D	Homo sapiens	14-23	
9798267-5	1998	Therefore, we compared the effect of doxorubicin on prolidase activity and collagen biosynthesis in cultured human skin fibroblasts.	Doxorubicin	37-48	peptidase D	Homo sapiens	52-61	
9798267-6	1998	We have found that doxorubicin induces coordinately inhibition of prolidase activity (IC50 approximately 10 +/- 3 microM) and collagen biosynthesis (IC50 approximately 15 +/- 3 microM) in cultured human skin fibroblasts.	Doxorubicin	19-30	peptidase D	Homo sapiens	66-75	
9798267-7	1998	The inhibitory effect of doxorubicin on prolidase activity and collagen biosynthesis was not due to cytotoxicity of this drug as shown by cell viability tetrazoline test.	Doxorubicin	25-36	peptidase D	Homo sapiens	40-49	
9798267-8	1998	The decrease in prolidase activity in fibroblasts treated with doxorubicin was not accompanied by differences in the amount of the enzyme protein recovered from these cells as shown by western immunoblot analysis.	Doxorubicin	63-74	peptidase D	Homo sapiens	16-25	
9798267-10	1998	The data presented here rise possibility that doxorubicin-induced decrease in collagen biosynthesis is mostly due to the inhibition of prolidase activity.	Doxorubicin	46-57	peptidase D	Homo sapiens	135-144