PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26093057-0	2015	Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer.	Doxorubicin	81-92	C-C motif chemokine ligand 2	Homo sapiens	20-24	
26093057-6	2015	Plasma exposure of encapsulated liposomal doxorubicin positively correlated with the total exposure of plasma CCL2 and CCL5 in patients with recurrent epithelial ovarian cancer treated with PLD.	Doxorubicin	42-53	C-C motif chemokine ligand 2	Homo sapiens	110-114	
18697197-4	2008	Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF.	Doxorubicin	30-41	C-C motif chemokine ligand 2	Homo sapiens	125-129	
7800953-5	1994	In vitro experiments with KS-derived cell cultures, which most likely represent the KS spindle cells, suggested that liposomal doxorubicin may cause regression of KS via two different mechanisms: (i) by highly specific inhibition of KS spindle cell proliferation and (ii) by induction of monocyte chemoattractant protein-1 expression in KS spindle cells, which may result in increased recruitment of phagocytic cells (monocytes/macrophages) into the lesions.	Doxorubicin	127-138	C-C motif chemokine ligand 2	Homo sapiens	288-322	
12471621-3	2003	We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1.	Doxorubicin	71-82	C-C motif chemokine ligand 2	Homo sapiens	192-197	
12471621-3	2003	We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1.	Doxorubicin	163-174	C-C motif chemokine ligand 2	Homo sapiens	192-197	
12471621-6	2003	MCP-1 antigen levels increased approximately 100-fold in doxorubicin-treated H69 cells.	Doxorubicin	57-68	C-C motif chemokine ligand 2	Homo sapiens	0-5	
12471621-7	2003	RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells.	Doxorubicin	55-66	C-C motif chemokine ligand 2	Homo sapiens	34-39	
12471621-7	2003	RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells.	Doxorubicin	55-66	C-C motif chemokine ligand 2	Homo sapiens	80-85	
12471621-10	2003	IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology.	Doxorubicin	232-243	C-C motif chemokine ligand 2	Homo sapiens	9-14	
12471621-10	2003	IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology.	Doxorubicin	232-243	C-C motif chemokine ligand 2	Homo sapiens	142-147	
18697197-6	2008	Treatment of tumor cells with doxorubicin and antibodies neutralizing G-CSF, CCL2 or CCL5 had higher inhibitory effects than each modality used alone.	Doxorubicin	30-41	C-C motif chemokine ligand 2	Homo sapiens	77-81	
16465414-1	2006	We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved.	Doxorubicin	31-42	C-C motif chemokine ligand 2	Homo sapiens	131-165	
12908082-0	2003	Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells.	Doxorubicin	47-58	C-C motif chemokine ligand 2	Homo sapiens	38-43	
12908082-2	2003	The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay.	Doxorubicin	110-121	C-C motif chemokine ligand 2	Homo sapiens	130-166	
12908082-2	2003	The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay.	Doxorubicin	110-121	C-C motif chemokine ligand 2	Homo sapiens	168-173