PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18697197-6 2008 Treatment of tumor cells with doxorubicin and antibodies neutralizing G-CSF, CCL2 or CCL5 had higher inhibitory effects than each modality used alone. Doxorubicin 30-41 C-C motif chemokine ligand 2 Homo sapiens 77-81 26093057-0 2015 Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer. Doxorubicin 81-92 C-C motif chemokine ligand 2 Homo sapiens 20-24 26093057-6 2015 Plasma exposure of encapsulated liposomal doxorubicin positively correlated with the total exposure of plasma CCL2 and CCL5 in patients with recurrent epithelial ovarian cancer treated with PLD. Doxorubicin 42-53 C-C motif chemokine ligand 2 Homo sapiens 110-114 18697197-4 2008 Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF. Doxorubicin 30-41 C-C motif chemokine ligand 2 Homo sapiens 125-129 16465414-1 2006 We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved. Doxorubicin 31-42 C-C motif chemokine ligand 2 Homo sapiens 131-165 7800953-5 1994 In vitro experiments with KS-derived cell cultures, which most likely represent the KS spindle cells, suggested that liposomal doxorubicin may cause regression of KS via two different mechanisms: (i) by highly specific inhibition of KS spindle cell proliferation and (ii) by induction of monocyte chemoattractant protein-1 expression in KS spindle cells, which may result in increased recruitment of phagocytic cells (monocytes/macrophages) into the lesions. Doxorubicin 127-138 C-C motif chemokine ligand 2 Homo sapiens 288-322 12908082-0 2003 Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells. Doxorubicin 47-58 C-C motif chemokine ligand 2 Homo sapiens 38-43 12908082-2 2003 The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay. Doxorubicin 110-121 C-C motif chemokine ligand 2 Homo sapiens 130-166 12908082-2 2003 The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay. Doxorubicin 110-121 C-C motif chemokine ligand 2 Homo sapiens 168-173 12471621-3 2003 We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. Doxorubicin 71-82 C-C motif chemokine ligand 2 Homo sapiens 192-197 12471621-3 2003 We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. Doxorubicin 163-174 C-C motif chemokine ligand 2 Homo sapiens 192-197 12471621-6 2003 MCP-1 antigen levels increased approximately 100-fold in doxorubicin-treated H69 cells. Doxorubicin 57-68 C-C motif chemokine ligand 2 Homo sapiens 0-5 12471621-7 2003 RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. Doxorubicin 55-66 C-C motif chemokine ligand 2 Homo sapiens 34-39 12471621-7 2003 RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. Doxorubicin 55-66 C-C motif chemokine ligand 2 Homo sapiens 80-85 12471621-10 2003 IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. Doxorubicin 232-243 C-C motif chemokine ligand 2 Homo sapiens 9-14 12471621-10 2003 IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. Doxorubicin 232-243 C-C motif chemokine ligand 2 Homo sapiens 142-147