PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33495450-6 2021 CRISPR/Cas9-mediated MALAT1 promoter deletion in BT-549 TNBC model enhanced sensitivity to paclitaxel and doxorubicin, suggesting a role for MALAT1 in conferring resistance. Doxorubicin 106-117 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 21-27 34512027-13 2021 Results: The MALAT-1 was upregulated in the doxorubicin-resistant U-2OS osteosarcoma cells. Doxorubicin 44-55 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 13-20 34512027-14 2021 Downregulating MALAT-1 in the doxorubicin-resistant cells inhibited the proliferation, migration, and invasiveness, increased the ratio of cells in the G0/G1 phase, promoted apoptosis. Doxorubicin 30-41 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 15-22 34512027-15 2021 In the doxorubicin-resistant U-2OS cells, the extracellular regulated protein kinases (ERK) phosphorylation was declined, which could be reversed by downregulating MALAT-1. Doxorubicin 7-18 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 164-171 34512027-16 2021 In vivo assay indicated that the growth of doxorubicin-resistant solid osteosarcoma could be suppressed by downregulating MALAT-1. Doxorubicin 43-54 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 122-129 34512027-17 2021 Conclusion: Our study provides evidence that doxorubicin may upregulate MALAT-1 in osteosarcoma. Doxorubicin 45-56 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 72-79 33414433-0 2021 LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells. Doxorubicin 23-34 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 73-79 33414433-8 2021 These results revealed DANCR played a critical role in Doxorubicin-induced apoptosis in colorectal cancer cells, which was achieved by the interaction between DANCR and QK to enhance the expression of MALAT1. Doxorubicin 55-66 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 201-207 32965597-3 2021 Dysregulation of MALAT1 could regulate doxorubicin resistance of hepatocellular carcinoma (HCC), but how MALAT1 involving in managing doxorubicin resistance remains unclear yet. Doxorubicin 134-145 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 105-111 32965597-4 2021 We aimed to elucidate the specific molecular mechanism of MALAT1 with doxorubicin resistance in HCC cells. Doxorubicin 70-81 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 58-64 32965597-6 2021 Xenograft tumor model was created to confirm the biological function of MALAT1 in doxorubicin resistance of HCC cells in vivo. Doxorubicin 82-93 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 72-78 32965597-8 2021 Knockdown of MALAT1 regulated doxorubicin resistance of HCC cells through inhibiting cell proliferation, migration, invasion and promoting apoptosis, but antisense miR-3129-5p released the functional effect of MALAT1 knockdown. Doxorubicin 30-41 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 13-19 32965597-10 2021 Xenograft tumor model suggested that dysregulation of MALAT1 regulated tumor growth and Nova1 to mediate doxorubicin resistance of HCC cells by as a sponge for miR-3129-5p in vivo. Doxorubicin 105-116 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 54-60 32965597-11 2021 Elevation of LncRNA MALAT1 mediated doxorubicin resistance and the progression of HCC via a MALAT1/miR-3129-5p/Nova1 axis. Doxorubicin 36-47 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 20-26 32965597-11 2021 Elevation of LncRNA MALAT1 mediated doxorubicin resistance and the progression of HCC via a MALAT1/miR-3129-5p/Nova1 axis. Doxorubicin 36-47 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 92-98 32965597-0 2021 LncRNA MALAT1 mediates doxorubicin resistance of hepatocellular carcinoma by regulating miR-3129-5p/Nova1 axis. Doxorubicin 23-34 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 7-13 32965597-3 2021 Dysregulation of MALAT1 could regulate doxorubicin resistance of hepatocellular carcinoma (HCC), but how MALAT1 involving in managing doxorubicin resistance remains unclear yet. Doxorubicin 39-50 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 17-23 32623440-0 2020 Suppression of Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Potentiates Cell Apoptosis and Drug Sensitivity to Taxanes and Adriamycin in Breast Cancer. Doxorubicin 162-172 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 91-97 32623440-3 2020 This study was set to investigate the regulatory role of MALAT1 on the chemosensitivity of breast cancer cells to taxanes (Tax) and adriamycin (Adr). Doxorubicin 132-142 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 57-63 32384281-0 2020 Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a. Doxorubicin 61-72 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 19-25 32384281-11 2020 LncRNA-MALAT1/miR-92a-3p/ATG4a partially mediates the cardioprotective roles of exosomeHypoxia in Dox-induced cardiac damage. Doxorubicin 98-101 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 7-13 28770558-9 2017 MALAT1 was significantly upregulated by bortezomib and doxorubicin. Doxorubicin 55-66 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 0-6