PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25801352-8 2015 To establish the significance of IL-18 in EoE pathogenesis, we examined DOX-inducible rtTA-CC10-IL-18 bitransgenic mice that induce IL-18 protein expression in the oesophagus. Doxorubicin 72-75 interleukin 18 Mus musculus 96-101 31600901-6 2019 Our data shows that the Dox treatment significantly increased expression of inflammasome markers (TLR4 and NLRP3), pyroptotic markers (caspase-1, IL1-beta, and IL-18), cell signaling proteins (MyD88, p-P38, and p-JNK), pro-inflammatory M1 macrophages, and TNF-alpha cytokine. Doxorubicin 24-27 interleukin 18 Mus musculus 160-165 28926719-6 2018 The results show significant increase in the expression of caspase-1, IL-1beta, and IL-18 following treatment with Dox, which was inhibited by ES-exos but not mouse embryonic fibroblast exosomes. Doxorubicin 115-118 interleukin 18 Mus musculus 84-89 34474337-5 2021 Mechanismly, MCC950 had the potential to inhibit DOX-induced the cleavage of NLRP3, ASC, Caspase-1, IL-18, IL-1beta and GSDMD in vivo. Doxorubicin 49-52 interleukin 18 Mus musculus 100-105 25801352-8 2015 To establish the significance of IL-18 in EoE pathogenesis, we examined DOX-inducible rtTA-CC10-IL-18 bitransgenic mice that induce IL-18 protein expression in the oesophagus. Doxorubicin 72-75 interleukin 18 Mus musculus 96-101