PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25918240-6	2015	The enzyme kinetics of "wild-type" canine cbr1 (cbr1 D218) and a variant isoform (cbr1 V218) were characterized with the substrates daunorubicin and menadione, as well as the flavonoid inhibitor rutin.	Daunorubicin	132-144	carbonyl reductase [NADPH] 1	Canis lupus familiaris	42-46	
25918240-9	2015	Rutin acted as a competitive inhibitor for the reduction of daunorubicin (cbr1 D218 Ki: 1.84 +- 1.02 muM, cbr1 V218 Ki: 1.38 +- 0.47 muM).	Daunorubicin	60-72	carbonyl reductase [NADPH] 1	Canis lupus familiaris	74-78	
25918240-10	2015	These studies show that canine cbr1 metabolizes daunorubicin and provide the necessary foundation to characterize the role of cbr1 in the variable pharmacodynamics of anthracyclines in canine cancer patients.	Daunorubicin	48-60	carbonyl reductase [NADPH] 1	Canis lupus familiaris	31-35	
27506315-3	2016	Canine carbonyl reductase 1 (cbr1) catalyzes the reduction of daunorubicin into daunorubicinol.	Daunorubicin	62-74	carbonyl reductase [NADPH] 1	Canis lupus familiaris	7-27	
27506315-3	2016	Canine carbonyl reductase 1 (cbr1) catalyzes the reduction of daunorubicin into daunorubicinol.	Daunorubicin	62-74	carbonyl reductase [NADPH] 1	Canis lupus familiaris	29-33