PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15053878-2 2004 Here, we demonstrate that NF-kappa B induced by cytotoxic stimuli, such as ultraviolet light (UV-C) and the chemotherapeutic drugs daunorubicin/doxorubicin, is functionally distinct to that seen with the inflammatory cytokine TNF and is an active repressor of antiapoptotic gene expression. Daunorubicin 131-143 nuclear factor kappa B subunit 1 Homo sapiens 26-36 15580299-4 2005 In vitro monotherapy with Dauno or VBL induced the degradation of IkappaBalpha, provoked the translocation of NF-kappaB p65/50 to the nucleus and stimulated the expression of an NF-kappaB-activatable reporter gene. Daunorubicin 26-31 nuclear factor kappa B subunit 1 Homo sapiens 110-119 15580299-4 2005 In vitro monotherapy with Dauno or VBL induced the degradation of IkappaBalpha, provoked the translocation of NF-kappaB p65/50 to the nucleus and stimulated the expression of an NF-kappaB-activatable reporter gene. Daunorubicin 26-31 nuclear factor kappa B subunit 1 Homo sapiens 178-187 16682957-4 2006 Cooperation between p53 and NF-kappaB was required for activation of COX-2 promoter in response to daunomycin, a DNA-damaging agent. Daunorubicin 99-109 nuclear factor kappa B subunit 1 Homo sapiens 28-37 15053878-4 2004 Furthermore, UV-C and daunorubicin inhibit TNF-induced NF-kappa B transactivation, indicating that this is a dominant effect. Daunorubicin 22-34 nuclear factor kappa B subunit 1 Homo sapiens 55-65 9199297-11 1997 Furthermore, since recent data indicate that NF-kappaB protects cells from tumor necrosis factor alpha-, ionizing radiation-, and chemotherapeutic agent daunorubicin-mediated apoptosis, our results provide an explanation for chemotherapeutic resistance in ER-negative breast cancers. Daunorubicin 153-165 nuclear factor kappa B subunit 1 Homo sapiens 45-54 12351644-3 2002 NF-kappaB was activated in HepG2 cells shortly after therapeutic doses of ionizing radiation or daunorubicin treatment that translated into up-regulation of kappaB-dependent genes. Daunorubicin 96-108 nuclear factor kappa B subunit 1 Homo sapiens 0-9 12032660-5 2002 In parallel, we found that, by inhibiting degradation of I kappa B, hGH gene transfer diminished NF-kappa B entry into the nuclei of U937 cells exposed to daunorubicin. Daunorubicin 155-167 nuclear factor kappa B subunit 1 Homo sapiens 97-107 12527911-3 2003 We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Daunorubicin 141-151 nuclear factor kappa B subunit 1 Homo sapiens 17-26 12527911-4 2003 Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Daunorubicin 125-135 nuclear factor kappa B subunit 1 Homo sapiens 15-24 11278608-6 2001 On the other hand, daunorubicin, an NF-kappaB activator, increased the steady-state levels of CFTR mRNA. Daunorubicin 19-31 nuclear factor kappa B subunit 1 Homo sapiens 36-45 11082419-1 2000 Daunomycin is a potent inducer of p53 and NF-kappaB transcription factors. Daunorubicin 0-10 nuclear factor kappa B subunit 1 Homo sapiens 42-51 11082419-4 2000 We demonstrated, in human breast and colon carcinoma cells, the binding of NF-kappaB dimers to the kappaB site and the transcriptional activation of the human p21 promoter by daunomycin and by NF-kappaB subunits, thereby confirming the functionality of this kappaB binding site. Daunorubicin 175-185 nuclear factor kappa B subunit 1 Homo sapiens 75-84 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 55-64 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 175-184 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 175-184 9528861-2 1998 In the HCT116 colon carcinoma cell line, which retains a wild-type inducible p53 gene, we show that the anthracycline daunomycin is a potent inducer of p53 and NF-kappaB transcription factors. Daunorubicin 118-128 nuclear factor kappa B subunit 1 Homo sapiens 160-169 9528861-4 1998 In addition, daunomycin induced the p53 promoter through the binding of p50/p65 NF-kappaB heterodimers to the kappaB site in the p53 promoter. Daunorubicin 13-23 nuclear factor kappa B subunit 1 Homo sapiens 72-75 9528861-4 1998 In addition, daunomycin induced the p53 promoter through the binding of p50/p65 NF-kappaB heterodimers to the kappaB site in the p53 promoter. Daunorubicin 13-23 nuclear factor kappa B subunit 1 Homo sapiens 80-89 9528861-7 1998 We conclude that the p53-activating signal generated by daunomycin is partially regulated by NF-kappaB. Daunorubicin 56-66 nuclear factor kappa B subunit 1 Homo sapiens 93-102 21187919-8 2010 Furthermore, the combination of MNP-Fe3O4 with adriamycin or daunorubicin increased p53 protein levels and decreased NF-kappaB protein levels more than adriamycin or daunorubicin alone, indicating that MNP-Fe3O4 could enhance the effect of chemotherapeutic drugs on p53 and NF-kappaB. Daunorubicin 61-73 nuclear factor kappa B subunit 1 Homo sapiens 117-126 9169462-4 1997 Like paclitaxel, vinblastine, vincristine, daunomycin, and doxorubicin each caused activation of NF-kappaB. Daunorubicin 43-53 nuclear factor kappa B subunit 1 Homo sapiens 97-106 8864119-2 1996 The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Daunorubicin 133-145 nuclear factor kappa B subunit 1 Homo sapiens 43-65 8864119-2 1996 The activation of the transcription factor nuclear factor-kappa B (NF-kappaB) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Daunorubicin 133-145 nuclear factor kappa B subunit 1 Homo sapiens 67-76 30559256-7 2019 IMPLICATIONS: RELA and PARP1 form a positive feedback loop to regulate DNA damage repair, simultaneous inhibition of NF-kappaB and PARP1 increases the antileukemic efficacy of daunorubicin in vitro and in vivo, broadening the use of PARP1 inhibitors. Daunorubicin 176-188 nuclear factor kappa B subunit 1 Homo sapiens 117-126 24899604-1 2014 OBJECTIVES: The aim of this study was to observe the effects of bortezomib (PS341) on the expression of NF-kappaB (nuclear factor-kappa B), IkappaB (inhibitor kB) and P-gp (P-glycoprotein) of K562 cells induced by daunorubicin (K562/DNR). Daunorubicin 214-226 nuclear factor kappa B subunit 1 Homo sapiens 104-113 9148901-0 1997 Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. Daunorubicin 0-12 nuclear factor kappa B subunit 1 Homo sapiens 23-31 9148901-3 1997 Since the generation of ceramide has been directly linked with the activation of the transcription factor, NFkappaB, this was investigated as a novel target for the action of daunorubicin. Daunorubicin 175-187 nuclear factor kappa B subunit 1 Homo sapiens 107-115 9148901-4 1997 Here we describe how treatment of HL-60 promyelocytes and Jurkat T lymphoma cells with daunorubicin results in the activation of the transcription factor NFkappaB. Daunorubicin 87-99 nuclear factor kappa B subunit 1 Homo sapiens 154-162 9148901-7 1997 Daunorubicin also induced IkappaB degradation and increased the expression of an NFkappaB-linked reporter gene. Daunorubicin 0-12 nuclear factor kappa B subunit 1 Homo sapiens 81-89 9148901-13 1997 These data therefore suggest that the effect of daunorubicin on NFkappaB is unlikely to involve ceramide, but may involve reactive oxygen species generated as a result of endogenous cellular processes rather than reductive metabolism of the drug. Daunorubicin 48-60 nuclear factor kappa B subunit 1 Homo sapiens 64-72 8932379-5 1996 We now show that a series of topoisomerase poisons (actinomycin D, camptothecin, daunomycin and etoposide) also activate NF-kappaB (NFKB1/RelA dimer) in ACH-2 and CEM cells. Daunorubicin 81-91 nuclear factor kappa B subunit 1 Homo sapiens 121-130 8932379-5 1996 We now show that a series of topoisomerase poisons (actinomycin D, camptothecin, daunomycin and etoposide) also activate NF-kappaB (NFKB1/RelA dimer) in ACH-2 and CEM cells. Daunorubicin 81-91 nuclear factor kappa B subunit 1 Homo sapiens 132-137 27974700-5 2017 Cytarabine downregulated TNTs and inhibited NF-kappaB alone and in combination with daunorubicin, providing additional support for involvement of the NF-kappaB pathway in TNT formation. Daunorubicin 84-96 nuclear factor kappa B subunit 1 Homo sapiens 150-159 21520400-5 2011 It is demonstrated that ImageStream assessment of receptor-mediated (TNFalpha) and drug (Daunorubicin, DNR)-induced NF-kappaB translocation in leukemic cell lines correlates well with microscopy analysis and Western blot analysis. Daunorubicin 89-101 nuclear factor kappa B subunit 1 Homo sapiens 116-125 21187919-8 2010 Furthermore, the combination of MNP-Fe3O4 with adriamycin or daunorubicin increased p53 protein levels and decreased NF-kappaB protein levels more than adriamycin or daunorubicin alone, indicating that MNP-Fe3O4 could enhance the effect of chemotherapeutic drugs on p53 and NF-kappaB. Daunorubicin 61-73 nuclear factor kappa B subunit 1 Homo sapiens 274-283 19725919-5 2009 Chemotherapeutic drugs that intercalate into DNA and inhibit topoisomerase II such as Doxorubicin, Daunorubicin and Mitoxantrone stimulate NF-kappaB DNA binding and transcriptional activity prior to induction of cell death. Daunorubicin 99-111 nuclear factor kappa B subunit 1 Homo sapiens 139-148 19725919-6 2009 Importantly, specific inhibition of drug-induced NF-kappaB activation by IkappaBalpha-SR or RNA interference against p65 significantly reduces apoptosis upon treatment with Doxorubicin, Daunorubicin or Mitoxantrone. Daunorubicin 186-198 nuclear factor kappa B subunit 1 Homo sapiens 49-58