PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2580485-1 1985 In order to increase the selective localization of anti-cancer drugs to the target tumor cells, polyclonal or monoclonal anti alpha-fetoprotein antibody (aAFP) was conjugated with anti-cancer drugs such as daunomycin (DM), adriamycin (AM) and mitomycin C (MMC) by chemical modification. Daunorubicin 206-216 alpha-fetoprotein Rattus norvegicus 126-143 2476405-0 1989 Overcoming effect of antibody against rat alpha-fetoprotein (AFP) on the growth of daunorubicin-resistant mutant rat ascites hepatoma cell line AH66. Daunorubicin 83-95 alpha-fetoprotein Rattus norvegicus 42-59 2476405-0 1989 Overcoming effect of antibody against rat alpha-fetoprotein (AFP) on the growth of daunorubicin-resistant mutant rat ascites hepatoma cell line AH66. Daunorubicin 83-95 alpha-fetoprotein Rattus norvegicus 61-64 2476405-1 1989 A daunorubicin (DNR)-resistant variant (AH66DR) of alpha-fetoprotein (AFP)-producing rat ascites hepatoma AH66 was established. Daunorubicin 2-14 alpha-fetoprotein Rattus norvegicus 51-68 2476405-1 1989 A daunorubicin (DNR)-resistant variant (AH66DR) of alpha-fetoprotein (AFP)-producing rat ascites hepatoma AH66 was established. Daunorubicin 2-14 alpha-fetoprotein Rattus norvegicus 70-73 2440563-0 1987 Therapeutic effect of treatment with polyclonal or monoclonal antibodies to alpha-fetoprotein that have been conjugated to daunomycin via a dextran bridge: studies with an alpha-fetoprotein-producing rat hepatoma tumor model. Daunorubicin 123-133 alpha-fetoprotein Rattus norvegicus 76-93 2440563-1 1987 Purified monoclonal mouse or polyclonal horse antibodies (Ab) to rat alpha-fetoprotein (AFP) were conjugated with daunomycin via a dextran bridge. Daunorubicin 114-124 alpha-fetoprotein Rattus norvegicus 69-86 2440563-1 1987 Purified monoclonal mouse or polyclonal horse antibodies (Ab) to rat alpha-fetoprotein (AFP) were conjugated with daunomycin via a dextran bridge. Daunorubicin 114-124 alpha-fetoprotein Rattus norvegicus 88-91 2440563-7 1987 There was a slight therapeutic effect with either antibody or daunomycin alone but treatment with the AFP Ab-daunomycin conjugates significantly prolonged survival and 60% of these treated animals were "tumor free" when sacrificed on day 100. Daunorubicin 109-119 alpha-fetoprotein Rattus norvegicus 102-105 2440563-8 1987 Serial quantitation of the concentration of AFP in the serum of the treated tumor-bearing or in the tumor-resected rats correlated with the therapeutic effectiveness of the Ab-daunomycin conjugates. Daunorubicin 176-186 alpha-fetoprotein Rattus norvegicus 44-47 6176999-0 1982 Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells. Daunorubicin 25-35 alpha-fetoprotein Rattus norvegicus 93-110 6206272-0 1984 An anti-alpha-fetoprotein antibody-daunorubicin conjugate with a novel poly-L-glutamic acid derivative as intermediate drug carrier. Daunorubicin 35-47 alpha-fetoprotein Rattus norvegicus 8-25 6206272-1 1984 In studies on antitumor antibody-cytotoxic drug conjugates as potential antitumor agents with improved tumor specificity, daunorubicin [(DM) daunomycin] was conjugated with an affinity-purified horse antibody to rat alpha-fetoprotein (AFP) with a novel derivative of poly-L-glutamic acid (PLGA) as the intermediate drug carrier. Daunorubicin 122-134 alpha-fetoprotein Rattus norvegicus 216-233 6206272-1 1984 In studies on antitumor antibody-cytotoxic drug conjugates as potential antitumor agents with improved tumor specificity, daunorubicin [(DM) daunomycin] was conjugated with an affinity-purified horse antibody to rat alpha-fetoprotein (AFP) with a novel derivative of poly-L-glutamic acid (PLGA) as the intermediate drug carrier. Daunorubicin 122-134 alpha-fetoprotein Rattus norvegicus 235-238 6200034-0 1983 Effect of a conjugate of daunomycin and purified polyclonal or monoclonal antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells. Daunorubicin 25-35 alpha-fetoprotein Rattus norvegicus 127-144 6200034-2 1983 The monoclonal antibodies as well as horse anti-rat AFP antibodies were coupled via a dextran bridge to daunomycin. Daunorubicin 104-114 alpha-fetoprotein Rattus norvegicus 52-55 6200034-6 1983 Daunomycin conjugates with horse-anti-AFP and monoclonal mouse anti-AFP were capable of delaying the tumor development more efficiently than were the controls of antibodies or free drug, mixtures of drug with antibodies, and a conjugate of drug and normal Ig. Daunorubicin 0-10 alpha-fetoprotein Rattus norvegicus 38-41 6200034-6 1983 Daunomycin conjugates with horse-anti-AFP and monoclonal mouse anti-AFP were capable of delaying the tumor development more efficiently than were the controls of antibodies or free drug, mixtures of drug with antibodies, and a conjugate of drug and normal Ig. Daunorubicin 0-10 alpha-fetoprotein Rattus norvegicus 68-71 6185954-0 1982 Chemotherapy by intravenous administration of conjugates of daunomycin with monoclonal and conventional anti-rat alpha-fetoprotein antibodies. Daunorubicin 60-70 alpha-fetoprotein Rattus norvegicus 113-130 6185954-2 1982 The monoclonal antibodies as well as horse anti-rat AFP were coupled via a dextran bridge to daunomycin. Daunorubicin 93-103 alpha-fetoprotein Rattus norvegicus 52-55 6185954-6 1982 Daunomycin conjugates with horse anti-AFP and monoclonal mouse anti-AFP were capable of delaying the tumor development more efficiently than the controls of antibodies or free drug, mixtures of drug with antibodies, and a conjugate of drug and normal immunoglobulin. Daunorubicin 0-10 alpha-fetoprotein Rattus norvegicus 38-41 6185954-6 1982 Daunomycin conjugates with horse anti-AFP and monoclonal mouse anti-AFP were capable of delaying the tumor development more efficiently than the controls of antibodies or free drug, mixtures of drug with antibodies, and a conjugate of drug and normal immunoglobulin. Daunorubicin 0-10 alpha-fetoprotein Rattus norvegicus 68-71 6209394-1 1984 An anti-alpha-fetoprotein antibody-daunomycin conjugate. Daunorubicin 35-45 alpha-fetoprotein Rattus norvegicus 8-25 6209394-5 1984 Anti-AFP conjugate tended to be less cytotoxic than DM against the AFP-nonproducing rat ascites hepatoma AH272 cells, and in this case there was no difference between the cytotoxicities of anti-AFP conjugate and of normal conjugate. Daunorubicin 52-54 alpha-fetoprotein Rattus norvegicus 67-70 6209394-5 1984 Anti-AFP conjugate tended to be less cytotoxic than DM against the AFP-nonproducing rat ascites hepatoma AH272 cells, and in this case there was no difference between the cytotoxicities of anti-AFP conjugate and of normal conjugate. Daunorubicin 52-54 alpha-fetoprotein Rattus norvegicus 67-70 6176999-1 1982 Daunomycin was covalently attached via a dextran bridge to specific antibodies against rat alpha-fetoprotein produced in a horse. Daunorubicin 0-10 alpha-fetoprotein Rattus norvegicus 91-108