PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29031202-5	2017	We showed that niclosamide could inhibit OSCC cells proliferation through causing cell cycle arrest in G1 phase and promoting apoptosis, while the cell cycle-related proteins MCM2, MCM7, CDK2 and CDK4 were downregulated and the apoptosis-related proteins p53 and cleaved caspase-3 were upregulated.	Niclosamide	15-26	tumor protein p53	Homo sapiens	255-258	
30258081-3	2018	Here we identify niclosamide through a HTS screen for compounds selectively killing p53-deficient cells.	Niclosamide	17-28	tumor protein p53	Homo sapiens	84-87	
30258081-4	2018	Niclosamide impairs the growth of p53-deficient cells and of p53 mutant patient-derived ovarian xenografts.	Niclosamide	0-11	tumor protein p53	Homo sapiens	34-37	
30258081-4	2018	Niclosamide impairs the growth of p53-deficient cells and of p53 mutant patient-derived ovarian xenografts.	Niclosamide	0-11	tumor protein p53	Homo sapiens	61-64	
30258081-5	2018	Metabolome profiling reveals that niclosamide induces mitochondrial uncoupling, which renders mutant p53 cells susceptible to mitochondrial-dependent apoptosis through preferential accumulation of arachidonic acid (AA), and represents a first-in-class inhibitor of p53 mutant tumors.	Niclosamide	34-45	tumor protein p53	Homo sapiens	101-104	
30258081-5	2018	Metabolome profiling reveals that niclosamide induces mitochondrial uncoupling, which renders mutant p53 cells susceptible to mitochondrial-dependent apoptosis through preferential accumulation of arachidonic acid (AA), and represents a first-in-class inhibitor of p53 mutant tumors.	Niclosamide	34-45	tumor protein p53	Homo sapiens	265-268	
30258081-7	2018	Therefore, we propose a new paradigm for targeting cancers defective in the p53 pathway, by exploiting their vulnerability to niclosamide-induced mitochondrial uncoupling.	Niclosamide	126-137	tumor protein p53	Homo sapiens	76-79	
34638761-3	2021	Previously, we reported that niclosamide targets a metabolic vulnerability in p53-deficient tumours, providing a basis for patient stratification and personalised treatment strategies.	Niclosamide	29-40	tumor protein p53	Homo sapiens	78-81	
34638761-8	2021	Notably, quantitative scoring of drug sensitivity suggests that elimination of its nitro group enhanced the target selectivity of niclosamide against p53 deficiency.	Niclosamide	130-141	tumor protein p53	Homo sapiens	150-153	
35460941-0	2022	Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis.	Niclosamide	13-24	tumor protein p53	Homo sapiens	124-127	
35460941-5	2022	The results showed, briefly, an exposure to niclosamide and quinacrine led to an increased apoptosis-related protein p53, cleaved caspase-3 and cleaved PARP and autophagy-related protein LC3B expression, and a decreased expression of autophagy-related protein p62, finally leading to cell apoptosis and autophage.	Niclosamide	44-55	tumor protein p53	Homo sapiens	117-120	
35460941-8	2022	To sum up, we developed a new, safe strategy for melanoma treatment by using low doses of niclosamide and quinacrine to treat melanoma; and found a novel mechanism by which the combination application of low doses of niclosamide and quinacrine exerts an efficient anti-melanoma effect through activation of autophagy-mediated p53-dependent apoptosis.	Niclosamide	90-101	tumor protein p53	Homo sapiens	326-329	
35460941-8	2022	To sum up, we developed a new, safe strategy for melanoma treatment by using low doses of niclosamide and quinacrine to treat melanoma; and found a novel mechanism by which the combination application of low doses of niclosamide and quinacrine exerts an efficient anti-melanoma effect through activation of autophagy-mediated p53-dependent apoptosis.	Niclosamide	217-228	tumor protein p53	Homo sapiens	326-329	
33383327-7	2021	Mechanism study unfolded that, similar to niclosamide, 2 inhibited growth of cancer cells via p 53 activation and subsequent underwent cytochrome c dependent apoptosis.	Niclosamide	42-53	tumor protein p53	Homo sapiens	94-98