PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34360618-7 2021 In contrast, niclosamide, an inhibitor of TMEM16A, blocked mucus production and mucus secretion in vivo and in vitro. Niclosamide 13-24 anoctamin 1, calcium activated chloride channel Mus musculus 42-49 35163010-5 2022 The potential of encapsulated niclosamide to inhibit TMEM16A whole-cell Cl- currents and intracellular Ca2+ signalling was assessed in airway epithelial cells in vitro. Niclosamide 30-41 anoctamin 1, calcium activated chloride channel Mus musculus 53-60 32859916-6 2020 Knockout of Tmem16a or inhibition of TMEM16A in vivo by the FDA-approved drugs niclosamide and benzbromarone, as well as the TMEM16A-specific inhibitor Ani9 largely reduced cyst enlargement and abnormal cyst cell proliferation. Niclosamide 79-90 anoctamin 1, calcium activated chloride channel Mus musculus 12-19 32859916-6 2020 Knockout of Tmem16a or inhibition of TMEM16A in vivo by the FDA-approved drugs niclosamide and benzbromarone, as well as the TMEM16A-specific inhibitor Ani9 largely reduced cyst enlargement and abnormal cyst cell proliferation. Niclosamide 79-90 anoctamin 1, calcium activated chloride channel Mus musculus 37-44 31391337-4 2019 Here we demonstrate that the FDA-approved drug niclosamide, a potent inhibitor of TMEM16A identified by high-throughput screening, is an inhibitor of both TMEM16A and TMEM16F. Niclosamide 47-58 anoctamin 1, calcium activated chloride channel Mus musculus 82-89 31391337-4 2019 Here we demonstrate that the FDA-approved drug niclosamide, a potent inhibitor of TMEM16A identified by high-throughput screening, is an inhibitor of both TMEM16A and TMEM16F. Niclosamide 47-58 anoctamin 1, calcium activated chloride channel Mus musculus 155-162 31391337-7 2019 TMEM16A and TMEM16F support exocytic release of mucus and inflammatory mediators, both of which are blocked by niclosamide. Niclosamide 111-122 anoctamin 1, calcium activated chloride channel Mus musculus 0-7