PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7923205-6 1994 Northern blot analysis using a human complementary DNA probe for the multidrug resistance-associated protein (MRP) demonstrated overexpression of murine mrp in each of the vincristine-selected sublines. Vincristine 172-183 ATP binding cassette subfamily C member 3 Homo sapiens 69-108 16620787-8 2006 In contrast, vincristine (10 nM and 100 nM), a ligand for ABCB1 and ABCC1-3 and a potential PXR/CAR ligand, induced ABCC2 and ABCC3 expression in LS174T cells at 48 h (372+/-87% and 303+/-42%, respectively, p<0.05). Vincristine 13-24 ATP binding cassette subfamily C member 3 Homo sapiens 126-131 11410522-2 2001 Cancer Res., 5: 673-680, 1999), we found, in a panel of 23 lung cancer cell lines that had not been selected for in vitro drug resistance, that the mRNA levels of MRP3 and MRP1, two members of the ATP-binding cassette superfamily of transport proteins, correlated with resistance to doxorubicin, vincristine, VP-16, and cis-diamminedicholoroplatinum(II). Vincristine 296-307 ATP binding cassette subfamily C member 3 Homo sapiens 163-167 10348353-6 1999 These cells demonstrated significantly increased sensitivity to the high affinity MRP substrates vincristine, doxorubicin, sodium arsenate and potassium antimony tartrate, but not to the poor MRP substrates, taxol or cisplatin. Vincristine 97-108 ATP binding cassette subfamily C member 3 Homo sapiens 82-85 10100721-7 1999 In addition, the mRNA levels of both MRP and MRP3 correlated with resistance of the cell lines to vincristine, VP-16, and cis-diamminedichloroplatinum(II). Vincristine 98-109 ATP binding cassette subfamily C member 3 Homo sapiens 45-49 9413193-5 1997 Positive correlations between the MRP gene levels in three cell lines and the modulation effects of verapamil in VP-16, Dox, and vincristine were observed. Vincristine 129-140 ATP binding cassette subfamily C member 3 Homo sapiens 34-37 9045962-9 1996 However, verapamil significantly increased the sensitivity to etoposide, doxorubicin and vincristine in cells highly expressing MRP gene. Vincristine 89-100 ATP binding cassette subfamily C member 3 Homo sapiens 128-131 7640209-12 1995 We conclude from these results that selection of the SW-1573 cell line for low levels of doxorubicin or vincristine resistance, predominantly results in MDR with reduced drug accumulation associated with the presence of an altered MRP protein. Vincristine 104-115 ATP binding cassette subfamily C member 3 Homo sapiens 231-234 10606242-7 1999 The MRP3-transfected cells displayed approximately 4-fold resistance to etoposide and approximately 2-fold resistance to vincristine, compared with control transfected cells. Vincristine 121-132 ATP binding cassette subfamily C member 3 Homo sapiens 4-8 10364464-9 1999 In contrast, a multidrug resistance (MDR) phenotype due to expression of the multidrug resistance-associated protein (MRP) is most prominent in T98G cells and is amenable to modulation by indomethacin, suggesting that inhibition of MRP is at least in partly responsible for the potentiation of doxorubicin and vincristine cytotoxicity by NSAID. Vincristine 310-321 ATP binding cassette subfamily C member 3 Homo sapiens 77-116 10364464-9 1999 In contrast, a multidrug resistance (MDR) phenotype due to expression of the multidrug resistance-associated protein (MRP) is most prominent in T98G cells and is amenable to modulation by indomethacin, suggesting that inhibition of MRP is at least in partly responsible for the potentiation of doxorubicin and vincristine cytotoxicity by NSAID. Vincristine 310-321 ATP binding cassette subfamily C member 3 Homo sapiens 118-121 10329417-4 1999 RU486, when used at 10 microM, a concentration close to plasma concentrations achievable in humans, strongly enhanced the sensitivity of GLC4/Sb30 cells towards two known cytotoxic substrates of MRP, the anticancer drug vincristine and the heavy metal salt potassium antimonyl tartrate. Vincristine 220-231 ATP binding cassette subfamily C member 3 Homo sapiens 195-198 10408915-3 1999 Rifampicin was shown to increase accumulation of the MRP substrate calcein in GLC4/ADR cells in a dose-dependent manner by inhibiting its MRP-mediated efflux from the cells; it also enhanced intracellular retention of another substrate of MRP such as the anticancer drug vincristine in the resistant cells. Vincristine 271-282 ATP binding cassette subfamily C member 3 Homo sapiens 53-56 9003796-3 1997 Here we demonstrate that vanadate-induced trapping of 8-azido-ATP in MRP was stimulated in the presence of glutathione, oxidized glutathione and the anti-cancer drugs VP-16 and vincristine. Vincristine 177-188 ATP binding cassette subfamily C member 3 Homo sapiens 69-72 8615623-4 1996 In vincristine and adriamycin selected cells, topoisomerase II alpha- and II beta-MRNA levels were reduced, and in vincristine selected cells the MRP-mRNA was elevated compared with the sensitive line. Vincristine 115-126 ATP binding cassette subfamily C member 3 Homo sapiens 146-149 7923205-6 1994 Northern blot analysis using a human complementary DNA probe for the multidrug resistance-associated protein (MRP) demonstrated overexpression of murine mrp in each of the vincristine-selected sublines. Vincristine 172-183 ATP binding cassette subfamily C member 3 Homo sapiens 110-113 7927879-0 1994 Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Vincristine 120-131 ATP binding cassette subfamily C member 3 Homo sapiens 24-63 7927879-0 1994 Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Vincristine 120-131 ATP binding cassette subfamily C member 3 Homo sapiens 65-68 7927879-4 1994 Out of glioma cell lines, 2, namely IN500 and T98G, which had elevated MRP mRNA levels, showed the highest resistance to multiple anti-cancer agents such as etoposide, vincristine and adriamycin, and decreased intracellular accumulation of etoposide. Vincristine 168-179 ATP binding cassette subfamily C member 3 Homo sapiens 71-74 7825064-8 1994 These results indicate that MRP overexpressed in the resistant cells may be responsible for the reduced accumulation of adriamycin and vincristine and that both the increased expression of MRP and decreased levels of topoisomerase II underlie the drug resistance in C-A120, C-A500, and C-A1000 cell lines. Vincristine 135-146 ATP binding cassette subfamily C member 3 Homo sapiens 28-31