PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9256485-5	1997	In a clone of M1 cells that did not express p53, vincristine or doxorubicin induced protease activation and apoptosis that were not suppressed by protease inhibitors, but were suppressed by interleukin 6.	Vincristine	49-60	interleukin 6	Homo sapiens	190-203	
33279931-5	2020	Consequently, abrogation of STAT3 or IL6R expression in Med8A-R led to restored chemosensitivity to vincristine, highlighting a prominent role for canonical IL-6/STAT3 signaling in acquired drug resistance.	Vincristine	100-111	interleukin 6	Homo sapiens	157-161	
33279931-6	2020	Furthermore, Med8A-S subjected to conditioning exposure with IL-6, termed Med8A-IL6+ cells, exhibited enhanced vincristine resistance, increased expression of pY705-STAT3 and IL6R, and increased secretion of IL-6.	Vincristine	111-122	interleukin 6	Homo sapiens	61-65	
33279931-6	2020	Furthermore, Med8A-S subjected to conditioning exposure with IL-6, termed Med8A-IL6+ cells, exhibited enhanced vincristine resistance, increased expression of pY705-STAT3 and IL6R, and increased secretion of IL-6.	Vincristine	111-122	interleukin 6	Homo sapiens	80-83	
19607970-6	2009	These findings proved that inhibition of IL-6 function prevented neuropathic pain caused by vincristine.	Vincristine	92-103	interleukin 6	Homo sapiens	41-45	
31010006-4	2019	Our present findings confirm that vincristine stimulates the secretion of tumor growth factors class beta and interleukin-6 from cancer-associated fibroblasts as a result of paracrine stimulation by cancer cells.	Vincristine	34-45	interleukin 6	Homo sapiens	110-123	
25046000-5	2014	When delivered in combination with doxorubicin, one of the drugs, vincristine, was also capable of synergistically activating the NLRP3-dependent inflammasome and increasing expression of IL-1beta, IL-6, and CXCL1.	Vincristine	66-77	interleukin 6	Homo sapiens	198-202	
25046000-7	2014	Three small-molecule inhibitors known to suppress activity of kinases situated upstream of mitogen-activated kinases (MAPKs) inhibited the expression of IL-1beta, IL-6, and CXCL1 when doxorubicin and vincristine were used singly or together, so specific kinase inhibitors may be useful in reducing inflammation in patients receiving chemotherapy.	Vincristine	200-211	interleukin 6	Homo sapiens	163-167