PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24849444-4 2014 RESULTS: Compared with the negative and blank control groups, COX-2 siRNA transfection resulted in significant growth inhibition of KB/VCR cells exposed to vincristine (P<0.01), down-regulated the expressions of COX-2 and MDR-1 mRNAs, and obviously increased Rho-123 accumulation in KB/VCR cells. Vincristine 156-167 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 24849444-5 2014 CONCLUSION: COX-2 gene silencing can enhance the chemosensitivity of KB/VCR cells to vincristine, the mechanism of which may involve down-regulated MDR-1 gene expression and inhibition of P-glycoprotein activity. Vincristine 85-96 mitochondrially encoded cytochrome c oxidase II Homo sapiens 12-17 21835258-0 2012 The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. Vincristine 91-102 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9