PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34517333-0	2022	Fluoride exposure induces mitochondrial damage and mitophagy via activation of the IL-17A pathway in hepatocytes.	Fluorides	0-8	interleukin 17A	Mus musculus	83-89	
34517333-6	2022	Furthermore, the protein expression levels of IL-17A pathway key proteins, IL-17A, IL-17R, and Act1 were increased, but IkappaB was decreased after fluoride exposure.	Fluorides	148-156	interleukin 17A	Mus musculus	46-52	
34517333-6	2022	Furthermore, the protein expression levels of IL-17A pathway key proteins, IL-17A, IL-17R, and Act1 were increased, but IkappaB was decreased after fluoride exposure.	Fluorides	148-156	interleukin 17A	Mus musculus	75-81	
34517333-8	2022	To further verify the role of the IL-17A pathway in fluoride-induced hepatocyte mitochondrial damage and mitophagy disorder, the IL-17A was added and knocked out in cells of animals.	Fluorides	52-60	interleukin 17A	Mus musculus	34-40	
34517333-9	2022	The results showed that the addition of IL-17A aggravated fluoride-induced liver morphology and functional damage, activation of the IL-17A pathway, mitochondrial injury, and mitophagy, but the IL-17A knockout mitigated fluoride-induced changes.	Fluorides	58-66	interleukin 17A	Mus musculus	40-46	
34517333-9	2022	The results showed that the addition of IL-17A aggravated fluoride-induced liver morphology and functional damage, activation of the IL-17A pathway, mitochondrial injury, and mitophagy, but the IL-17A knockout mitigated fluoride-induced changes.	Fluorides	58-66	interleukin 17A	Mus musculus	194-200	
34517333-9	2022	The results showed that the addition of IL-17A aggravated fluoride-induced liver morphology and functional damage, activation of the IL-17A pathway, mitochondrial injury, and mitophagy, but the IL-17A knockout mitigated fluoride-induced changes.	Fluorides	220-228	interleukin 17A	Mus musculus	194-200	
34517333-10	2022	These results suggested that fluoride exposure induced mitochondrial damage and mitophagy through the IL-17A pathway in hepatocytes.	Fluorides	29-37	interleukin 17A	Mus musculus	102-108	
34517333-3	2022	Our previous studies revealed fluoride-induced hepatic injury through interleukin 17A (IL-17A) pathway, but the underlying cellular mechanism remains unclear.	Fluorides	30-38	interleukin 17A	Mus musculus	70-85	
34517333-3	2022	Our previous studies revealed fluoride-induced hepatic injury through interleukin 17A (IL-17A) pathway, but the underlying cellular mechanism remains unclear.	Fluorides	30-38	interleukin 17A	Mus musculus	87-93	
34517333-4	2022	Hence, this research explored the mechanism of IL-17A pathway and mitophagy in fluoride-induced liver injury through the use of the mice fluorosis model, IL-17A addition fluorosis cell model, IL-17A gene knockout mice fluorosis model, flow cytometry, immunohistochemistry, fluorescence double staining, ELISA, western blotting, and other techniques.	Fluorides	79-87	interleukin 17A	Mus musculus	47-53	
33244669-2	2021	Results showed that compared with the control group, no differential expression proteins (DEPs) were found in the 1 mmol/L fluoride group; however, eight DEPs were upregulated in the 2.5 mmol/L fluoride group, including macrophage inflammatory protein-3alpha (MIP-3alpha), interleukin-21 (IL-21), IL-13, IL-17F, IL-28A, transforming growth factor type beta 1 (TGF-beta1), IL-23, and IL-17A.	Fluorides	194-202	interleukin 17A	Mus musculus	383-389	
33297146-0	2021	Interleukin 17A deficiency alleviates fluoride-induced testicular injury by inhibiting the immune response and apoptosis.	Fluorides	38-46	interleukin 17A	Mus musculus	0-15	
33297146-8	2021	Remarkably, IL-17A knockout in mice ameliorated the effects of F on testicular damage, semen quality, testicular morphology, and the immune response.	Fluorides	63-64	interleukin 17A	Mus musculus	12-18	
33244669-5	2021	Kyoto Encyclopedia of Genes and Genomes analysis showed that these DEPs primarily involved 12 pathways enriched in the cytokine-cytokine receptor interaction and IL-17 signaling pathway after 2.5 mmol/L fluoride treatment.	Fluorides	203-211	interleukin 17A	Mus musculus	162-167	
31703480-0	2019	Fluoride induces autoimmune orchitis involved with enhanced IL-17A secretion in mice testis.	Fluorides	0-8	interleukin 17A	Mus musculus	60-66	
30225638-0	2018	Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes.	Fluorides	0-8	interleukin 17A	Mus musculus	53-58	
27572304-0	2016	Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride.	Fluorides	106-114	interleukin 17A	Mus musculus	8-13	
27572304-6	2016	The high expression of the IL-17 signal pathway was a response to the invasion of the testicular immune system due to extracellular fluoride.	Fluorides	132-140	interleukin 17A	Mus musculus	27-32