PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34527658-4 2021 The main function of MGAM is to digest terminal starch products left after the enzymatic action of alpha-amylase; hence, MGAM becomes an efficient drug target for insulin resistance. Starch 48-54 maltase-glucoamylase Homo sapiens 21-25 34527658-4 2021 The main function of MGAM is to digest terminal starch products left after the enzymatic action of alpha-amylase; hence, MGAM becomes an efficient drug target for insulin resistance. Starch 48-54 maltase-glucoamylase Homo sapiens 121-125 6204606-14 1983 In contrast, M-G catalysed the hydrolysis of starch, amylose and maltose with a Km of 3.12 mM, 7.59 mM and 3.52 mM respectively, and had no action on sucrose or palatinose. Starch 45-51 maltase-glucoamylase Homo sapiens 13-16 30996822-2 2019 MGAM, a therapeutic target for type 2 diabetes, is alpha-1,4-glucosidase and expressed in the intestine to catalyze starch digestion. Starch 116-122 maltase-glucoamylase Homo sapiens 0-4 6414283-4 1983 In vitro enzyme inhibition studies assessed the ability of the brush border enzyme maltase/glucoamylase to degrade starch in the presence of the starch blockers. Starch 115-121 maltase-glucoamylase Homo sapiens 83-103 6414283-4 1983 In vitro enzyme inhibition studies assessed the ability of the brush border enzyme maltase/glucoamylase to degrade starch in the presence of the starch blockers. Starch 145-151 maltase-glucoamylase Homo sapiens 83-103 6414283-5 1983 A highly purified solution of rat and human maltase/glucoamylase was capable of degrading a starch solution, while 40 mM Tris-HCl (a known maltase/glucoamylase inhibitor) completely abolished the enzyme activity. Starch 92-98 maltase-glucoamylase Homo sapiens 44-64 6414283-7 1983 The ineffectiveness in vivo could be explained, in part, by the ability of the brush border enzyme maltase/glucoamylase to hydrolyze starch in the presence of starch blockers. Starch 133-139 maltase-glucoamylase Homo sapiens 99-119 6414283-7 1983 The ineffectiveness in vivo could be explained, in part, by the ability of the brush border enzyme maltase/glucoamylase to hydrolyze starch in the presence of starch blockers. Starch 159-165 maltase-glucoamylase Homo sapiens 99-119 31254546-2 2019 Small intestinal breakdown of starch-derived substrates occurs through the mechanisms of small intestinal brush border enzymes, maltase-glucoamylase and sucrase-isomaltase. Starch 30-36 maltase-glucoamylase Homo sapiens 128-148 29762381-1 2018 BACKGROUND AND HYPOTHESES: Human starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic alpha-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGAM]). Starch 33-39 maltase-glucoamylase Homo sapiens 235-255 29465310-1 2018 Dietary starch is finally converted to glucose for absorption by the small intestine mucosal alpha-glucosidases (sucrase-isomaltase [SI] and maltase-glucoamylase), and control of this process has health implications. Starch 8-14 maltase-glucoamylase Homo sapiens 141-161 29762381-1 2018 BACKGROUND AND HYPOTHESES: Human starch digestion is a multienzyme process involving 6 different enzymes: salivary and pancreatic alpha-amylase; sucrase and isomaltase (from sucrose-isomaltase [SI]), and maltase and glucoamylase (from maltase-glucoamylase [MGAM]). Starch 33-39 maltase-glucoamylase Homo sapiens 257-261 29762382-3 2018 Evidence points to the importance of maltase-glucoamylase in young infants and its effect on starch digestion. Starch 93-99 maltase-glucoamylase Homo sapiens 37-57 23137569-4 2012 We then performed validation testing using a functional MGAM analysis that involved starch ingestion followed by measuring blood glucose and insulin levels as well as hydrogen breath levels. Starch 84-90 maltase-glucoamylase Homo sapiens 56-60 28267073-3 2017 Six enzyme activities, 2 alpha-amylases (Amy), and 4 mucosal alpha-glucosidases (maltases), including maltase-glucoamylase (Mgam) and sucrase-isomaltase (Si) subunit activities, are needed to digest starch to absorbable free glucose. Starch 199-205 maltase-glucoamylase Homo sapiens 102-122 28267073-4 2017 Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose. Starch 26-32 maltase-glucoamylase Homo sapiens 62-66 28267073-4 2017 Amy breaks down insoluble starch to soluble dextrins; mucosal Mgam and Si can either directly digest starch to glucose or convert the post-alpha-amylolytic dextrins to glucose. Starch 101-107 maltase-glucoamylase Homo sapiens 62-66 26162745-0 2015 Modeling of cooked starch digestion process using recombinant human pancreatic alpha-amylase and maltase-glucoamylase for in vitro evaluation of alpha-glucosidase inhibitors. Starch 19-25 maltase-glucoamylase Homo sapiens 97-117 26162745-1 2015 In human, digestion of cooked starch mainly involves breaking down of alpha-amylase to alpha-limit dextrins and small linear malto-oligosaccharides, which are in turn hydrolyzed to glucose by the gut mucosal maltase-glucoamylase (MGAM). Starch 30-36 maltase-glucoamylase Homo sapiens 208-228 26162745-1 2015 In human, digestion of cooked starch mainly involves breaking down of alpha-amylase to alpha-limit dextrins and small linear malto-oligosaccharides, which are in turn hydrolyzed to glucose by the gut mucosal maltase-glucoamylase (MGAM). Starch 30-36 maltase-glucoamylase Homo sapiens 230-234 26162745-2 2015 Human pancreatic alpha-amylase (HPA), amino- and carboxyl-terminal portions of MGAM (ntMGAM and ctMGAM) catalyze the hydrolysis of alpha-D-(1,4) glycosidic linkages in starch, playing a crucial role in the production of glucose in the human lumen. Starch 168-174 maltase-glucoamylase Homo sapiens 79-83 25816913-6 2015 Inhibition of fast-digesting Ct-MGAM and Ct-SI by EGCG and chlorogenic acid could lead to a slow, but complete, digestion of starch for improved glycemic response of starchy foods with potential health benefit. Starch 125-131 maltase-glucoamylase Homo sapiens 32-36 23964564-7 2014 Because they mediate the final steps of starch digestion, both MGAM and SI are important target enzymes for the treatment of type-2 diabetes. Starch 40-46 maltase-glucoamylase Homo sapiens 63-67 22036121-1 2011 In humans, both the N-terminal catalytic domain (NtMGAM) and the C-terminal catalytic domain (CtMGAM) of small intestinal maltase glucoamylase (MGAM) are alpha-glycosidases that catalyze the hydrolysis of alpha-(1 4) glycosidic linkages in the process of starch digestion, and are considered to be the main therapeutic targets for type 2 diabetes. Starch 255-261 maltase-glucoamylase Homo sapiens 122-142 23103656-0 2012 Direct starch digestion by sucrase-isomaltase and maltase-glucoamylase. Starch 7-13 maltase-glucoamylase Homo sapiens 50-70 22563462-0 2012 Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal alpha-glucosidase subunit. Starch 41-47 maltase-glucoamylase Homo sapiens 58-78 22563462-3 2012 Gelatinized normal maize starch was digested with N- and C-terminal subunits of recombinant mammalian maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) of varying amounts and digestion periods. Starch 25-31 maltase-glucoamylase Homo sapiens 124-128 22036121-1 2011 In humans, both the N-terminal catalytic domain (NtMGAM) and the C-terminal catalytic domain (CtMGAM) of small intestinal maltase glucoamylase (MGAM) are alpha-glycosidases that catalyze the hydrolysis of alpha-(1 4) glycosidic linkages in the process of starch digestion, and are considered to be the main therapeutic targets for type 2 diabetes. Starch 255-261 maltase-glucoamylase Homo sapiens 51-55 21924903-1 2011 Human maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are two human intestinal glucosidases responsible for the final step of starch hydrolysis. Starch 134-140 maltase-glucoamylase Homo sapiens 6-26 21924903-1 2011 Human maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are two human intestinal glucosidases responsible for the final step of starch hydrolysis. Starch 134-140 maltase-glucoamylase Homo sapiens 28-32 18036614-1 2008 Human maltase-glucoamylase (MGAM) is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. Starch 122-128 maltase-glucoamylase Homo sapiens 6-26 20356844-1 2010 Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are small intestinal enzymes that work concurrently to hydrolyze the mixture of linear alpha-1,4- and branched alpha-1,6-oligosaccharide substrates that typically make up terminal starch digestion products. Starch 242-248 maltase-glucoamylase Homo sapiens 6-26 20356844-1 2010 Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are small intestinal enzymes that work concurrently to hydrolyze the mixture of linear alpha-1,4- and branched alpha-1,6-oligosaccharide substrates that typically make up terminal starch digestion products. Starch 242-248 maltase-glucoamylase Homo sapiens 28-32 18356321-0 2008 Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. Starch 8-14 maltase-glucoamylase Homo sapiens 36-56 18356321-1 2008 The detailed mechanistic aspects for the final starch digestion process leading to effective alpha-glucogenesis by the 2 mucosal alpha-glucosidases, human sucrase-isomaltase complex (SI) and human maltase-glucoamylase (MGAM), are poorly understood. Starch 47-53 maltase-glucoamylase Homo sapiens 197-217 18356321-1 2008 The detailed mechanistic aspects for the final starch digestion process leading to effective alpha-glucogenesis by the 2 mucosal alpha-glucosidases, human sucrase-isomaltase complex (SI) and human maltase-glucoamylase (MGAM), are poorly understood. Starch 47-53 maltase-glucoamylase Homo sapiens 219-223 18036614-1 2008 Human maltase-glucoamylase (MGAM) is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. Starch 122-128 maltase-glucoamylase Homo sapiens 28-32 17485087-0 2007 Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant). Starch 19-25 maltase-glucoamylase Homo sapiens 66-86 18318124-1 2007 Maltase-glucoamylase and sucrase-isomaltase are two human glycosidases responsible for starch digestion. Starch 87-93 maltase-glucoamylase Homo sapiens 0-20 17592362-10 2007 CONCLUSIONS: MGAM primes and SI activity sustains and constrains prandial alpha-glucogenesis from starch oligomers at approximately 5% of the uninhibited rate. Starch 98-104 maltase-glucoamylase Homo sapiens 13-17 16817895-2 2006 Maltase-glucoamylase (MGA), a family 31 glycoside hydrolase, is an alpha-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion leading to the release of glucose. Starch 191-197 maltase-glucoamylase Homo sapiens 0-20 16817895-2 2006 Maltase-glucoamylase (MGA), a family 31 glycoside hydrolase, is an alpha-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion leading to the release of glucose. Starch 191-197 maltase-glucoamylase Homo sapiens 22-25 12547908-1 2003 Brush-border maltase-glucoamylase (MGA) activity serves as the final step of small intestinal digestion of linear regions of dietary starch to glucose. Starch 133-139 maltase-glucoamylase Homo sapiens 13-33 12547908-1 2003 Brush-border maltase-glucoamylase (MGA) activity serves as the final step of small intestinal digestion of linear regions of dietary starch to glucose. Starch 133-139 maltase-glucoamylase Homo sapiens 35-38 9446624-3 1998 20 and 3.2.1.3) activity serves as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition and that maltase-glucoamylase plays a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. Starch 60-66 maltase-glucoamylase Homo sapiens 171-191