PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12097830-0	2002	The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells.	Ticlopidine	25-36	interleukin 1 beta	Rattus norvegicus	50-68	
12097830-6	2002	RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner.	Ticlopidine	9-20	interleukin 1 beta	Rattus norvegicus	30-47	
12097830-6	2002	RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner.	Ticlopidine	9-20	interleukin 1 beta	Rattus norvegicus	49-57	
12097830-8	2002	IL-1beta alone stimulated both intracellular cAMP and cGMP contents, and the addition of ticlopidine further enhanced their contents.	Ticlopidine	89-100	interleukin 1 beta	Rattus norvegicus	0-8	
12097830-9	2002	KT 5720, a selective inhibitor of protein kinase A, but not KT 5823, a selective inhibitor of protein kinase G, abolished the enhancement of IL-1beta-induced nitrite production by ticlopidine.	Ticlopidine	180-191	interleukin 1 beta	Rattus norvegicus	141-149	
12097830-11	2002	CONCLUSION: We concluded that ticlopidine enhanced the IL-1beta-induced NO production via cAMP and subsequent activation of protein kinase A in cultured rat VSMC.	Ticlopidine	30-41	interleukin 1 beta	Rattus norvegicus	55-63