PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21156812-0	2011	Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.	Ticlopidine	37-48	cytochrome P450 2B4	Oryctolagus cuniculus	89-108	
21156812-1	2011	A recent X-ray crystal structure of a rabbit cytochrome P450 2B4 (CYP2B4)-ticlopidine complex indicated that the compound could be modeled with either the thiophene or chlorophenyl group oriented toward the heme prosthetic group.	Ticlopidine	74-85	cytochrome P450 2B4	Oryctolagus cuniculus	45-64	
21156812-1	2011	A recent X-ray crystal structure of a rabbit cytochrome P450 2B4 (CYP2B4)-ticlopidine complex indicated that the compound could be modeled with either the thiophene or chlorophenyl group oriented toward the heme prosthetic group.	Ticlopidine	74-85	cytochrome P450 2B4	Oryctolagus cuniculus	66-72	
21156812-3	2011	To evaluate the predictive value of these findings, the oxidation of ticlopidine by reconstituted CYP2B4 was studied and compared with CYP2B6, in which the thiophene portion of the molecule likely orients toward the heme.	Ticlopidine	69-80	cytochrome P450 2B4	Oryctolagus cuniculus	98-104	
21156812-7	2011	However, the amplitude (R(max)) of M1 and M6 formation was 4 to 5 times higher for CYP2B6 than CYP2B4, indicating a greater residence time of ticlopidine with its thiophene ring closer to heme in CYP2B6.	Ticlopidine	142-153	cytochrome P450 2B4	Oryctolagus cuniculus	95-101	
21156812-9	2011	Overall, the results suggest that the preferential orientation of ticlopidine in the active site of CYP2B4 predicted by X-ray crystallography and NMR studies is unproductive and that ticlopidine likely reorients within CYP2B4 to a more productive mode.	Ticlopidine	66-77	cytochrome P450 2B4	Oryctolagus cuniculus	100-106	
21156812-9	2011	Overall, the results suggest that the preferential orientation of ticlopidine in the active site of CYP2B4 predicted by X-ray crystallography and NMR studies is unproductive and that ticlopidine likely reorients within CYP2B4 to a more productive mode.	Ticlopidine	183-194	cytochrome P450 2B4	Oryctolagus cuniculus	219-225