PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22651985-10 2012 Pre-incubation with freshly isolated human granulocytes was not only associated with a myeloperoxidase-dependent degradation of clopidogrel, clopidogrel carboxylate and ticlopidine, but also with dose-dependent cytotoxicity of these compounds starting at 10 muM. Ticlopidine 169-180 myeloperoxidase Homo sapiens 87-102 22651985-13 2012 Concerning ticlopidine, both the parent compound and metabolites formed by myeloperoxidase may be myelotoxic in vivo. Ticlopidine 11-22 myeloperoxidase Homo sapiens 75-90 10859143-5 2000 The oxidation products of ticlopidine by the combination of myeloperoxidase and hydrogen peroxide were the same as those by HOCl: dehydrogenated ticlopidine and 2-chloroticlopidine. Ticlopidine 26-37 myeloperoxidase Homo sapiens 60-75 10859143-6 2000 A neutrophil-derived reactive metabolite of ticlopidine was trapped with GSH and the same ticlopidine-GSH conjugate was found in both the myeloperoxidase and HOCl systems. Ticlopidine 90-101 myeloperoxidase Homo sapiens 138-153