PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15155554-7	2004	In addition to CYP2B6, ticlopidine also inhibited both mephenytoin 4-hydroxylation (CYP2C19) (IC(50), 2.7 microM) and dextromethorphan O-demethylation (CYP2D6) (IC(50), 4.4 microM).	Ticlopidine	23-34	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	152-158	
23099620-7	2013	CONCLUSIONS: Ticlopidine increased exposure to tramadol, reduced its renal clearance and inhibited the formation of M1, most likely via inhibition of CYP2B6 and/or CYP2D6.	Ticlopidine	13-24	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	164-170	
18474675-2	2008	Mechanism-based CYP2B6 inhibitors (i.e., clopidogrel, ticlopidine, and triethylenethiophoramide) significantly inhibited the formation of M1 from sibutramine and M2 from M1, respectively; in contrast, no effect was observed when using potent inhibitors of eight P450 isozymes (CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A).	Ticlopidine	54-65	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	318-324	
19122335-3	2008	Ticlopidine also inhibited CYP2D6 (IC(50) of 0.354+/-0.158 microM).	Ticlopidine	0-11	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	27-33	
10759690-0	2000	In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.	Ticlopidine	84-95	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	126-132	
10759690-5	2000	RESULTS: TCL was a potent, competitive inhibitor of CYP2C19 (Ki = 1.2 +/- 0.5 microM) and of CYP2D6 (Ki = 3.4 +/- 0.3 microM).	Ticlopidine	9-12	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	93-99	
10759690-8	2000	CONCLUSIONS: TCL appears to be a broad-spectrum inhibitor of the CYP isoforms, but clinically significant adverse drug interactions are most likely with drugs that are substrates of CYP2C19 or CYP2D6.	Ticlopidine	13-16	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	193-199	
10460802-7	1999	Ticlopidine, a potent inhibitor of CYP2C19 and CYP2D6, inhibited bufuralol 1"-hydroxylation by each of these enzymes equipotently.	Ticlopidine	0-11	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	47-53