PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10759690-7 2000 TCL was also a moderate inhibitor of CYP1A2 (Ki = 49 +/- 19 microM) and a weak inhibitor of CYP2C9 (Ki > 75 microM), but its effect on the activities of CYP2E1 (Ki = 584 +/- 48 microM) and CYP3A (> 1000 microM) was marginal. Ticlopidine 0-3 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 37-43 20081260-0 2009 Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. Ticlopidine 43-54 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 58-64 20081260-4 2009 A comparative in vitro study provides clear evidence that ticlopidine and DDC, applied at concentrations that inhibit the above-mentioned CYP isoforms, potently (as compared to furafylline) inhibit human CYP1A2 and caffeine metabolism, in particular 1-N- and 3-N-demethylation. Ticlopidine 58-69 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 204-210 14563790-5 2004 Clopidogrel also inhibited CYP2C9, and ticlopidine also inhibited CYP1A2, with lower potency. Ticlopidine 39-50 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 66-72 18474675-2 2008 Mechanism-based CYP2B6 inhibitors (i.e., clopidogrel, ticlopidine, and triethylenethiophoramide) significantly inhibited the formation of M1 from sibutramine and M2 from M1, respectively; in contrast, no effect was observed when using potent inhibitors of eight P450 isozymes (CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A). Ticlopidine 54-65 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 277-283