PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29558951-5 2018 HM-3, an antitumor peptide including an Arg-Gly-Asp sequence, can specifically target integrin alphavbeta3 that is presented on some tumor cells. Glycine 44-47 integrin subunit alpha V Homo sapiens 86-106 32688289-1 2020 PURPOSE: Integrin alphavbeta3, a member of the arginine-glycine-aspartate (RGD)-binding subfamily, is associated with tumor angiogenesis and metastasis. Glycine 56-63 integrin subunit alpha V Homo sapiens 9-29 23796630-2 2014 Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-aspartic peptides for integrin alpha(v)beta3 targeting. Glycine 136-143 integrin subunit alpha V Homo sapiens 166-188 27768593-1 2017 The newly discovered short (9 amino acid) non-RGD S-S bridged cyclic peptide ALOS-4 (H-cycl(Cys-Ser-Ser-Ala-Gly-Ser-Leu-Phe-Cys)-OH), which binds to integrin alphavbeta3 is investigated as peptide carrier for targeted drug delivery against human metastatic melanoma. Glycine 108-111 integrin subunit alpha V Homo sapiens 149-169 26905697-1 2016 PURPOSE: Multimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin alphavbeta3 expression. Glycine 29-36 integrin subunit alpha V Homo sapiens 94-114 29053416-1 2017 Integrin alphavbeta3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides. Glycine 130-133 integrin subunit alpha V Homo sapiens 0-20 28004516-1 2017 Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery. Glycine 34-41 integrin subunit alpha V Homo sapiens 94-115 28004516-1 2017 Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery. Glycine 57-60 integrin subunit alpha V Homo sapiens 94-115 28110537-5 2017 We also confirmed this prediction by measuring dimeric cRGD (cyclic Arg-Gly-Asp) unbinding from integrin (alphavbeta3) using atomic force microscopy-based single-molecule force spectroscopy. Glycine 72-75 integrin subunit alpha V Homo sapiens 96-117 25207865-2 2014 Herein, we report the construction of arginine-glycine-aspartic acid-cysteine (RGDC) tetrapeptide functionalized and 10-hydroxycamptothecin (HCPT)-encapsulated magnetic nanohybrids (RFHEMNs) for integrin alphaVbeta3-targeted drug delivery. Glycine 47-54 integrin subunit alpha V Homo sapiens 195-215 24206140-2 2013 In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression. Glycine 50-53 integrin subunit alpha V Homo sapiens 83-103 22457887-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Glycine 131-134 integrin subunit alpha V Homo sapiens 12-32 23651498-2 2013 Integrin alphavbeta3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents. Glycine 49-56 integrin subunit alpha V Homo sapiens 0-20 22455451-3 2012 It is well-documented that the RGD (Arg-Gly-Asp) motif exhibits high binding affinity to integrin alpha(v)beta(3), which is abundantly expressed in cancer cells and specifically associated with angiogenesis on tumors. Glycine 40-43 integrin subunit alpha V Homo sapiens 89-113 22457888-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Glycine 131-134 integrin subunit alpha V Homo sapiens 12-32 22457890-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Glycine 131-134 integrin subunit alpha V Homo sapiens 12-32 19719118-1 2009 Integrin alpha(v)beta(3) plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence. Glycine 154-161 integrin subunit alpha V Homo sapiens 0-24 22664242-2 2012 Of these, the radiolabeled Arg-Gly- Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3. Glycine 31-34 integrin subunit alpha V Homo sapiens 120-142 22272823-3 2012 Peptide RGD sequence Arg-Gly-Asp targeted and combined to integrin alphavbeta3 which has been overexpressed on tumor endothelial cells and many different tumor cellsis a robust site for tumor angiogenesis molecular imaging and targeted therapy. Glycine 25-28 integrin subunit alpha V Homo sapiens 58-78 21447361-3 2011 The cyclic RGD (Arg-Gly-Asp) peptide, a specific ligand with affinity for Integrin alpha(v)beta(3) was coupled to the distal end of the PEG on the PEG-LP (RGD-PEG-LP). Glycine 20-23 integrin subunit alpha V Homo sapiens 74-98 20184307-2 2010 Radiolabeled RGD (Arg-Gly-Asp) peptides that specifically target integrin alphavbeta3 have great potential for tumor early detection and noninvasively monitoring the status of tumor angiogenesis. Glycine 22-25 integrin subunit alpha V Homo sapiens 65-85 19882657-0 2010 Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Glycine 117-120 integrin subunit alpha V Homo sapiens 28-51 11884718-3 2002 Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. Glycine 142-145 integrin subunit alpha V Homo sapiens 69-89 19225614-1 2009 A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence. Glycine 278-285 integrin subunit alpha V Homo sapiens 237-261 17166537-7 2007 Crystal structure of the extracellular segment of integrin alphavbeta3 in complexing with an Arg-Gly-Asp ligand. Glycine 97-100 integrin subunit alpha V Homo sapiens 50-70 19360404-1 2009 PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively. Glycine 26-29 integrin subunit alpha V Homo sapiens 135-159 19159928-6 2009 RESULTS: The new RGD dimers with the Gly(3) and PEG(4) linkers showed higher integrin alpha(v)beta(3) binding affinity than no-linker RGD dimer (RGD2). Glycine 37-40 integrin subunit alpha V Homo sapiens 77-100 19259068-2 2009 We have developed a peptide-like scaffold (regioselectively addressable functionalized template, RAFT), which holds four cyclo(-RGDfK-) (cRGD) motifs and proved that this molecule (called regioselectively addressable functionalized template-arginine-glycine-aspartic acid, RAFT-RGD) targets integrin alpha(v)beta(3) in vitro and in vivo. Glycine 250-257 integrin subunit alpha V Homo sapiens 291-314 17983645-2 2008 The plasma membrane receptor is located on integrin alphaVbeta3 at the Arg-Gly-Asp recognition site important to the binding by the integrin of extracellular matrix proteins. Glycine 75-78 integrin subunit alpha V Homo sapiens 43-63 17009846-1 2006 Integrin alphavbeta3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence. Glycine 150-157 integrin subunit alpha V Homo sapiens 0-20 16418218-8 2006 Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide. Glycine 187-190 integrin subunit alpha V Homo sapiens 62-85 15898744-6 2005 The FP assay was successfully applied to measure the binding affinity to integrin alpha(v)beta(3) of several cyclic peptides containing the Arg-Gly-Asp (RGD) motif. Glycine 144-147 integrin subunit alpha V Homo sapiens 73-97 8636223-1 1996 Integrin alpha v beta 3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components. Glycine 82-85 integrin subunit alpha V Homo sapiens 0-23 11779085-2 2001 Integrin alpha(v)beta3 interacts with RGD (Arg-Gly-Asp) sequence-containing proteins in the extracellular matrix. Glycine 47-50 integrin subunit alpha V Homo sapiens 0-22 10998238-1 2000 Integrin alpha(V)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an Arg-Gly-Asp (RGD) motif. Glycine 168-171 integrin subunit alpha V Homo sapiens 0-24 10773347-3 2000 The Arg-Gly-Asp sequence (RGD), is recognized by many integrins, including integrin alphavbeta3 (CD51/61). Glycine 8-11 integrin subunit alpha V Homo sapiens 75-95 10773347-4 2000 Coxsackievirus A9 (CAV-9), a human pathogen that has an Arg-Gly-Asp sequence in the VP1 capsid protein, has been known to be one of the many viruses that utilise integrin alphavbeta3 as a receptor. Glycine 60-63 integrin subunit alpha V Homo sapiens 162-182 8036014-2 1994 It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991). Glycine 25-28 integrin subunit alpha V Homo sapiens 238-261 8036014-2 1994 It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991). Glycine 33-36 integrin subunit alpha V Homo sapiens 238-261 1717468-0 1991 Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand. Glycine 9-16 integrin subunit alpha V Homo sapiens 82-105