PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34962430-11 2022 Sphingosine 1-phosphate might protect Nedd4-2 against ceramide-induced insulin resistance. sphingosine 1-phosphate 0-23 insulin Homo sapiens 71-78 33769715-0 2021 Sphingosine-1-phosphate as a key player of insulin secretion induced by high-density lipoprotein treatment. sphingosine 1-phosphate 0-23 insulin Homo sapiens 43-50 33769715-4 2021 The aim of this study was to investigate the contribution of sphingosine-1-phosphate (S1P) in the impact of HDL treatment on insulin secretion by pancreatic beta-cells and to determine its mechanisms. sphingosine 1-phosphate 61-84 insulin Homo sapiens 125-132 33769715-4 2021 The aim of this study was to investigate the contribution of sphingosine-1-phosphate (S1P) in the impact of HDL treatment on insulin secretion by pancreatic beta-cells and to determine its mechanisms. sphingosine 1-phosphate 86-89 insulin Homo sapiens 125-132 9006957-9 1997 ATP and insulin also potentiated, while rapamycin strongly inhibited, the mitogenic effects of sphingosine 1-phosphate (S1P). sphingosine 1-phosphate 95-118 insulin Homo sapiens 8-15 34980868-4 2022 The apoM-sphingosine-1-phosphate complex is critical to HDL antidiabetic activity, encompassing protection against insulin resistance, promotion of insulin secretion, enhanced beta-cell survival and inhibition of hepatic glucose production. sphingosine 1-phosphate 9-32 insulin Homo sapiens 115-122 34980868-4 2022 The apoM-sphingosine-1-phosphate complex is critical to HDL antidiabetic activity, encompassing protection against insulin resistance, promotion of insulin secretion, enhanced beta-cell survival and inhibition of hepatic glucose production. sphingosine 1-phosphate 9-32 insulin Homo sapiens 148-155 27600830-2 2016 Sphingosine 1-phosphate (S1P) is a lysophospholipid with paracrine and autocrine effects, which is associated with obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension through extracellular and intracellular signals to achieve a variety of biological functions. sphingosine 1-phosphate 0-23 insulin Homo sapiens 124-131 30060808-5 2018 Insulin sensitivity, de novo lipogenesis, and the resulting lipotoxicity, fibrosis, and angiogenesis are all seemingly regulated in a manner that involves either ceramide and/or sphingosine-1-phosphate. sphingosine 1-phosphate 178-201 insulin Homo sapiens 0-7 31915150-0 2020 Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate. sphingosine 1-phosphate 58-81 insulin Homo sapiens 19-26 31759099-1 2020 The bioactive lipid mediator sphingosine 1-phosphate (S1P) is considered to be involved in the development of insulin resistance (IR) via effects on oxidative stress; the mechanism however is not yet fully revealed. sphingosine 1-phosphate 29-52 insulin Homo sapiens 110-117 31759099-1 2020 The bioactive lipid mediator sphingosine 1-phosphate (S1P) is considered to be involved in the development of insulin resistance (IR) via effects on oxidative stress; the mechanism however is not yet fully revealed. sphingosine 1-phosphate 54-57 insulin Homo sapiens 110-117 24292566-0 2014 Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. sphingosine 1-phosphate 15-38 insulin Homo sapiens 60-67 24977487-0 2014 Divergent role of sphingosine 1-phosphate on insulin resistance. sphingosine 1-phosphate 18-41 insulin Homo sapiens 45-52 24977487-6 2014 However, recent work has also indicated that sphingosine 1-phosphate (S1P), a breakdown product of ceramide, modulate insulin signaling in different cell types. sphingosine 1-phosphate 45-68 insulin Homo sapiens 118-125 18219276-0 2008 Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype. sphingosine 1-phosphate 0-23 insulin Homo sapiens 34-41