PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34962430-11	2022	Sphingosine 1-phosphate might protect Nedd4-2 against ceramide-induced insulin resistance.	sphingosine 1-phosphate	0-23	insulin	Homo sapiens	71-78	
33769715-0	2021	Sphingosine-1-phosphate as a key player of insulin secretion induced by high-density lipoprotein treatment.	sphingosine 1-phosphate	0-23	insulin	Homo sapiens	43-50	
33769715-4	2021	The aim of this study was to investigate the contribution of sphingosine-1-phosphate (S1P) in the impact of HDL treatment on insulin secretion by pancreatic beta-cells and to determine its mechanisms.	sphingosine 1-phosphate	61-84	insulin	Homo sapiens	125-132	
33769715-4	2021	The aim of this study was to investigate the contribution of sphingosine-1-phosphate (S1P) in the impact of HDL treatment on insulin secretion by pancreatic beta-cells and to determine its mechanisms.	sphingosine 1-phosphate	86-89	insulin	Homo sapiens	125-132	
9006957-9	1997	ATP and insulin also potentiated, while rapamycin strongly inhibited, the mitogenic effects of sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	95-118	insulin	Homo sapiens	8-15	
34980868-4	2022	The apoM-sphingosine-1-phosphate complex is critical to HDL antidiabetic activity, encompassing protection against insulin resistance, promotion of insulin secretion, enhanced beta-cell survival and inhibition of hepatic glucose production.	sphingosine 1-phosphate	9-32	insulin	Homo sapiens	115-122	
34980868-4	2022	The apoM-sphingosine-1-phosphate complex is critical to HDL antidiabetic activity, encompassing protection against insulin resistance, promotion of insulin secretion, enhanced beta-cell survival and inhibition of hepatic glucose production.	sphingosine 1-phosphate	9-32	insulin	Homo sapiens	148-155	
27600830-2	2016	Sphingosine 1-phosphate (S1P) is a lysophospholipid with paracrine and autocrine effects, which is associated with obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension through extracellular and intracellular signals to achieve a variety of biological functions.	sphingosine 1-phosphate	0-23	insulin	Homo sapiens	124-131	
30060808-5	2018	Insulin sensitivity, de novo lipogenesis, and the resulting lipotoxicity, fibrosis, and angiogenesis are all seemingly regulated in a manner that involves either ceramide and/or sphingosine-1-phosphate.	sphingosine 1-phosphate	178-201	insulin	Homo sapiens	0-7	
31915150-0	2020	Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate.	sphingosine 1-phosphate	58-81	insulin	Homo sapiens	19-26	
31759099-1	2020	The bioactive lipid mediator sphingosine 1-phosphate (S1P) is considered to be involved in the development of insulin resistance (IR) via effects on oxidative stress; the mechanism however is not yet fully revealed.	sphingosine 1-phosphate	29-52	insulin	Homo sapiens	110-117	
31759099-1	2020	The bioactive lipid mediator sphingosine 1-phosphate (S1P) is considered to be involved in the development of insulin resistance (IR) via effects on oxidative stress; the mechanism however is not yet fully revealed.	sphingosine 1-phosphate	54-57	insulin	Homo sapiens	110-117	
24292566-0	2014	Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype.	sphingosine 1-phosphate	15-38	insulin	Homo sapiens	60-67	
24977487-0	2014	Divergent role of sphingosine 1-phosphate on insulin resistance.	sphingosine 1-phosphate	18-41	insulin	Homo sapiens	45-52	
24977487-6	2014	However, recent work has also indicated that sphingosine 1-phosphate (S1P), a breakdown product of ceramide, modulate insulin signaling in different cell types.	sphingosine 1-phosphate	45-68	insulin	Homo sapiens	118-125	
18219276-0	2008	Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.	sphingosine 1-phosphate	0-23	insulin	Homo sapiens	34-41