PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35527777-6	2022	ABC transporters, including ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2), are localized in the brain endothelial capillaries of the BBB, have a crucial role in the development of multidrug resistance and are modulated by phenothiazine derivatives.	phenothiazine	280-293	ATP binding cassette subfamily B member 1	Homo sapiens	28-69	
34284140-0	2021	The phenothiazine, trifluoperazine, is selectively lethal to ABCB1-expressing multidrug resistant cells.	phenothiazine	4-17	ATP binding cassette subfamily B member 1	Homo sapiens	61-66	
35527777-6	2022	ABC transporters, including ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2), are localized in the brain endothelial capillaries of the BBB, have a crucial role in the development of multidrug resistance and are modulated by phenothiazine derivatives.	phenothiazine	280-293	ATP binding cassette subfamily B member 1	Homo sapiens	71-76	
26026084-6	2015	The inhibition of the ABCB1 transporter was greater in the presence of the phenothiazine derivatives than for the known ABCB1 inhibitor verapamil.	phenothiazine	75-88	ATP binding cassette subfamily B member 1	Homo sapiens	22-27	
32852120-10	2021	Possible molecular targets of phenothiazine derivatives are the drug"s efflux pumps (ABCB1 and P-glycoprotein) and two parallel pathways (AKT and Wnt) regulated by the D2 receptor antagonists.	phenothiazine	30-43	ATP binding cassette subfamily B member 1	Homo sapiens	85-90	
32852120-10	2021	Possible molecular targets of phenothiazine derivatives are the drug"s efflux pumps (ABCB1 and P-glycoprotein) and two parallel pathways (AKT and Wnt) regulated by the D2 receptor antagonists.	phenothiazine	30-43	ATP binding cassette subfamily B member 1	Homo sapiens	95-109	
20023237-5	2009	RESULTS: In this way, these phenothiazine derivatives were identified as a group of atypical MDR modulators that differently interact with P-gp (as inhibitors) and MRP1 (as stimulators).	phenothiazine	28-41	ATP binding cassette subfamily B member 1	Homo sapiens	139-143	
20023237-2	2009	MATERIALS AND METHODS: In the present work, the interactions of seven commercially available phenothiazine derivatives, known P-glycoprotein inhibitors, with this transporter and MRP1 were compared.	phenothiazine	93-106	ATP binding cassette subfamily B member 1	Homo sapiens	126-140	
16750172-0	2006	Inhibition of the MDR1 transporter by new phenothiazine derivatives.	phenothiazine	42-55	ATP binding cassette subfamily B member 1	Homo sapiens	18-22	
16750172-2	2006	Here we describe some new phenothiazine derivatives, which possess strong in vitro MDR1 inhibitory activity.	phenothiazine	26-39	ATP binding cassette subfamily B member 1	Homo sapiens	83-87	
16750172-5	2006	According to our results the new structural elements built in these phenothiazine type compounds increased their MDR1 inhibitory activity, which may serve as a basis of the development of an effective MDR1 inhibitor drug.	phenothiazine	68-81	ATP binding cassette subfamily B member 1	Homo sapiens	113-117	
16750172-5	2006	According to our results the new structural elements built in these phenothiazine type compounds increased their MDR1 inhibitory activity, which may serve as a basis of the development of an effective MDR1 inhibitor drug.	phenothiazine	68-81	ATP binding cassette subfamily B member 1	Homo sapiens	201-205	
12711308-4	2003	Within each phenothiazine subset we found that anti-MDR activity (determined by P-glycoprotein inhibition assessed by flow cytometry) correlates with the theoretically calculated hydrophobicity value (logP) and experimental parameters (determined by calorimetry and fluorescence spectroscopy) of lipid bilayers.	phenothiazine	12-25	ATP binding cassette subfamily B member 1	Homo sapiens	80-94	
16516350-1	2006	Molecular orbital energies of energetically minimized series of extended aromatic and aminoalkyl side chain substituted phenothiazine compounds have been considered with respect to charge transfer (CT) binding properties to P-glycoprotein (P-gp) amino acids of the first P-gp loop.	phenothiazine	120-133	ATP binding cassette subfamily B member 1	Homo sapiens	224-238	
16516350-1	2006	Molecular orbital energies of energetically minimized series of extended aromatic and aminoalkyl side chain substituted phenothiazine compounds have been considered with respect to charge transfer (CT) binding properties to P-glycoprotein (P-gp) amino acids of the first P-gp loop.	phenothiazine	120-133	ATP binding cassette subfamily B member 1	Homo sapiens	240-244	
16516350-1	2006	Molecular orbital energies of energetically minimized series of extended aromatic and aminoalkyl side chain substituted phenothiazine compounds have been considered with respect to charge transfer (CT) binding properties to P-glycoprotein (P-gp) amino acids of the first P-gp loop.	phenothiazine	120-133	ATP binding cassette subfamily B member 1	Homo sapiens	271-275