PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19426680-5 2009 The dramatic loss of FPGS activity in 7-hydroxymethotrexate-resistant cells was associated with alterations in the expression of various genes aimed at preserving reduced folates and/or enhancing purine nucleotide biosynthesis, e.g. methylene tetrahydrofolate reductase, glycinamide ribonucleotide formyltransferase, adenosine deaminase, cystathionine beta synthase, as well as the ATP-dependent folate exporters BCRP/ABCG2 and MRP1/ABCC1. 7-hydroxymethotrexate 38-59 cystathionine beta-synthase Homo sapiens 338-365