PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1346997-7	1992	This was substantiated by the finding that CQA metabolism was completely inhibited by a polyclonal antibody directed against a pregnenolone 16 alpha-carbonitrile-inducible cytochrome P-450 of rat liver.	Amodiaquine	43-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	172-188	
16536934-1	2006	OBJECTIVES: To assess the relationship between the genetic and phenotypic factors linked to the cytochrome P-450 enzyme system and the response to the antimalarial drugs chloroquine, amodiaquine, mefloquine, and proguanil, as well as to determine how certain biological and social factors of the host influence the behavior of this enzymatic complex.	Amodiaquine	183-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	96-112	
31629065-7	2020	The cytotoxicity of ADQ was increased in CYP2C8 and 3A4 overexpressing HepG2 cells compared to HepG2/CYP vector cells, confirming that NADQ was more toxic than ADQ.	Amodiaquine	20-23	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-44	
27718269-0	2017	Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.	Amodiaquine	68-79	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41	
27718269-1	2017	AIMS: Oxidative bioactivation of amodiaquine (AQ) by cytochrome P450s to a reactive quinoneimine is considered as an important mechanism underlying its idiosyncratic hepatotoxicity.	Amodiaquine	33-44	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-68	
27718269-1	2017	AIMS: Oxidative bioactivation of amodiaquine (AQ) by cytochrome P450s to a reactive quinoneimine is considered as an important mechanism underlying its idiosyncratic hepatotoxicity.	Amodiaquine	46-48	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-68	
30976185-3	2019	The effect of pterostilbene on cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzyme activities were studied using the enzyme-selective substrates amodiaquine (CYP2C8), midazolam (CYP3A4), estradiol (UGT1A1), serotonin (UGT1A6) and mycophenolic acid (UGT1A8/9/10).	Amodiaquine	160-171	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-46	
30976185-3	2019	The effect of pterostilbene on cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzyme activities were studied using the enzyme-selective substrates amodiaquine (CYP2C8), midazolam (CYP3A4), estradiol (UGT1A1), serotonin (UGT1A6) and mycophenolic acid (UGT1A8/9/10).	Amodiaquine	160-171	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	48-51	
17286541-5	2007	Amodiaquine is almost entirely metabolized by the polymorphic cytochrome P450 (CYP) isoform 2C8 to the pharmacologically active desethylamodiaquine.	Amodiaquine	0-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-77	
17286541-5	2007	Amodiaquine is almost entirely metabolized by the polymorphic cytochrome P450 (CYP) isoform 2C8 to the pharmacologically active desethylamodiaquine.	Amodiaquine	0-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82