PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19487247-1	2009	An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase (UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro-40) and UGT2B10 (Leu-34).	Histidine	21-30	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	165-171	
26329791-3	2015	To test this, recombinant UGT1A4-P24T, with a C-terminal His-tag, was expressed in sf9 insect cells and affinity-purified for N-terminal protein sequencing.	Histidine	57-60	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	26-32	
22981363-3	2012	The equivalent position in UGT1A4 is also known to influence enzyme activity, whilst an N-terminal domain histidine (His37 in UGT1A9) is believed to function as the catalytic base in most UGT enzymes.	Histidine	106-115	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	27-33	
17956868-8	2007	Replacing Pro-40 of UGT1A4 by histidine expanded the glucuronidation activity of the enzyme to phenolic and carboxylic compounds, therefore, leading to UGT1A3-type isoform in terms of substrate specificity.	Histidine	30-39	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	20-26	
17956868-9	2007	Conversely, when His-40 residue of UGT1A3 was replaced with proline, the substrate specificity shifted toward that of UGT1A4 with loss of glucuronidation of phenolic substrates.	Histidine	17-20	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	118-124	
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	25-28	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67	
17956868-10	2007	Furthermore, mutation of His-39 residue of UGT1A1 (His-40 in UGT1A4) to proline led to loss of glucuronidation of phenols but not of estrogens.	Histidine	51-54	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67	
15313223-1	2004	In comparison with the amino acid sequences of seven species of glucosyltransferases and six species of galactosyltransferases, glutamine and histidine are highly conserved as the last amino acid residue of a glycosyltransferase-specific conserved region (UDPGT) in glucosyltransferases and galactosyltransferases, respectively.	Histidine	142-151	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	256-261	
15178418-4	2004	To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal.	Histidine	137-140	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	48-54	
15178418-4	2004	To further investigate the drugs metabolized by UGT1A4, the Bac-to-Bac expression system was used to express the recombinant UGT1A4 with His-tag on the C-terminal.	Histidine	137-140	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	125-131