PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10022234-6 1998 Koningic acid (KO), a chemical modifier and enzyme inhibitor of glyceraldehyde-3 phosphate dehydrogenase (GAPDH), induced the apoptosis too. heptelidic acid 0-13 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 64-104 10022234-6 1998 Koningic acid (KO), a chemical modifier and enzyme inhibitor of glyceraldehyde-3 phosphate dehydrogenase (GAPDH), induced the apoptosis too. heptelidic acid 0-13 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 106-111 10022234-6 1998 Koningic acid (KO), a chemical modifier and enzyme inhibitor of glyceraldehyde-3 phosphate dehydrogenase (GAPDH), induced the apoptosis too. heptelidic acid 15-17 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 64-104 10022234-6 1998 Koningic acid (KO), a chemical modifier and enzyme inhibitor of glyceraldehyde-3 phosphate dehydrogenase (GAPDH), induced the apoptosis too. heptelidic acid 15-17 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 106-111 7902582-2 1993 In search of a reagent that could discriminate between these two effects, we used the sesquiterpene antibiotic koningic acid, which binds to GAPDH at the Cys-149 of the active site. heptelidic acid 111-124 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 141-146 7902582-5 1993 Approximately 90% of GAPDH is present in the cytosol of human platelets, and the exposure of platelet cytosol to koningic acid inhibited GAPDH activity, while the soluble guanylyl cyclase (basal and sodium nitroprusside-stimulated) activity remained unaltered. heptelidic acid 113-126 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 21-26 7902582-5 1993 Approximately 90% of GAPDH is present in the cytosol of human platelets, and the exposure of platelet cytosol to koningic acid inhibited GAPDH activity, while the soluble guanylyl cyclase (basal and sodium nitroprusside-stimulated) activity remained unaltered. heptelidic acid 113-126 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 137-142 7902582-8 1993 Under the same conditions, koningic acid also inhibited basal and SNP- SNAP-, and SIN-1-stimulated NAD-dependent modification of GAPDH and its enzymatic activity. heptelidic acid 27-40 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 129-134 31748414-3 2020 To investigate this question, here we evolved resistance to koningic acid (KA), a natural product that specifically inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a rate-controlling glycolytic enzyme during the WE. heptelidic acid 60-73 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 125-165 1554737-1 1992 Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. heptelidic acid 0-13 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 39-79 1554737-1 1992 Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. heptelidic acid 0-13 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 81-86 35459092-0 2022 Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control. heptelidic acid 18-33 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 95-135 33609554-6 2021 Accordingly, 2-deoxy-glucose as inhibitor of the glycolytic enzymes hexokinase and phosphoglucose isomerase and heptelidic acid, an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, blunted this neutrophil response. heptelidic acid 112-127 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 145-185 32312046-1 2020 The natural product koningic acid (KA) is a selective covalent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a critical node in the glycolysis pathway. heptelidic acid 20-33 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 76-116 32312046-1 2020 The natural product koningic acid (KA) is a selective covalent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a critical node in the glycolysis pathway. heptelidic acid 20-33 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 118-123 31748414-3 2020 To investigate this question, here we evolved resistance to koningic acid (KA), a natural product that specifically inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a rate-controlling glycolytic enzyme during the WE. heptelidic acid 60-73 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 167-172 29721328-5 2018 Exposure of planarians to koningic acid, a specific inhibitor of glyceraldehyde-3-phosphate dehydrogenase, completely abolished extracellular acidification with little effect on oxygen consumption, which suggests that the majority of glucose catabolized in planarians is fated for aerobic glycolysis. heptelidic acid 26-39 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-105 12527413-4 2003 With the inhibitor koningic acid (KA), we showed a linear, concentration-dependent GAPDH inhibition, with 5 microM KA leading to a 79% reduction of GAPDH activity and a sixfold increase in MG. Changes in redox state produced by elevated pH also resulted in a 2.4-fold increase in MG production at pH 7.5 and a 13.4-fold increase at pH 7.8. heptelidic acid 19-32 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 83-88 12527413-4 2003 With the inhibitor koningic acid (KA), we showed a linear, concentration-dependent GAPDH inhibition, with 5 microM KA leading to a 79% reduction of GAPDH activity and a sixfold increase in MG. Changes in redox state produced by elevated pH also resulted in a 2.4-fold increase in MG production at pH 7.5 and a 13.4-fold increase at pH 7.8. heptelidic acid 19-32 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 148-153 28918937-3 2017 We establish a natural product, koningic acid (KA), to be a selective inhibitor of GAPDH, an enzyme we characterize to have differential control properties over metabolism during the WE. heptelidic acid 32-45 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 83-88 15788719-7 2005 Koningic acid (KA), a specific and irreversible inhibitor of GAPDH, inhibited both the classical enzymatic and the AsV-reducing activities of the enzyme in a concentration-dependent fashion. heptelidic acid 0-13 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 61-66