PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28716092-11	2017	Third, BzATP-induced release of IL1 family cytokines including IL1alpha, IL1beta, and IL18 was blocked in P2X7-/- microglia or by A-804598 in pro-inflammatory microglia, while the release of other cytokines/chemokines was independent of P2X7 activation.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	7-12	interleukin 1 beta	Mus musculus	73-80	
31100367-14	2019	This finding was further supported by results showing that downregulating IL-1beta by A-438079 and IL-1beta-neutralizing antibody similarly decreased P2X7R, cleaved caspase-1 and mature IL-1beta expression levels, whereas BzATP treatment increased these levels.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	222-227	interleukin 1 beta	Mus musculus	74-82	
28669743-8	2017	On the other hand, BzATP-mediated increased number of activated microglia and increased survival kinase levels in addition to increased caspase-1 and IL-1beta levels indicate the complex nature of the P2X7 receptor-mediated signaling in neuronal injury.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	19-24	interleukin 1 beta	Mus musculus	150-158	
28848393-9	2017	The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	178-183	interleukin 1 beta	Mus musculus	68-76	
11943809-2	2002	Activation of P2X(7) purinoceptors by ATP or 3"-O-(4-benzoyl)-benzoyl ATP (BzATP) induces the formation of cytolytic pores and provokes release of interleukin-1beta from immune cells.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	45-73	interleukin 1 beta	Mus musculus	147-164	
18559654-8	2008	Treatment with oATP or IL-1ra (IL-1beta receptor antagonist) reversed LPS plus BzATP-induced hyporeactivity to PE.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	79-84	interleukin 1 beta	Mus musculus	31-39	
18559654-10	2008	BzATP augmented LPS-induced IL-1beta release and iNOS protein expression, and these effects were also inhibited by oATP.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	0-5	interleukin 1 beta	Mus musculus	28-36	
11943809-2	2002	Activation of P2X(7) purinoceptors by ATP or 3"-O-(4-benzoyl)-benzoyl ATP (BzATP) induces the formation of cytolytic pores and provokes release of interleukin-1beta from immune cells.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	75-80	interleukin 1 beta	Mus musculus	147-164