PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18404518-4	2005	Caspase-3 activation and DNA fragmentation in rPCNs induced by the P2X(7)R agonist BzATP were inhibited by the P2X(7)R antagonist oxidized ATP (oATP) or by pre-treatment of cells with P2X(7)R antisense oligonucleotide indicating a direct involvement of the P2X(7)R in nucleotide-induced neuronal cell death.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	83-88	caspase 3	Rattus norvegicus	0-9	
18404518-5	2005	Moreover, Z-DEVD-FMK, a specific and irreversible cell permeable inhibitor of caspase-3, prevented BzATP-induced apoptosis in rPCNs.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	99-104	caspase 3	Rattus norvegicus	78-87	
18404518-6	2005	In addition, a specific caspase-8 inhibitor, Ac-IETD-CHO, significantly attenuated BzATP-induced caspase-9 and caspase-3 activation, suggesting that P2X(7)R-mediated apoptosis in rPCNs occurs primarily through an intrinsic caspase-8/9/3 activation pathway.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	83-88	caspase 3	Rattus norvegicus	111-120	
28488233-6	2017	The protein levels of P2X7, phosphorylated p38, ERK, active caspase-3 and NF-kappaB were significantly increased by ICH, which could be further increased by BzATP (P2X7 agonist) and reduced by BBG (P2X7 antagonist).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	157-162	caspase 3	Rattus norvegicus	60-69	
28488233-9	2017	Finally, the protein levels of phosphorylated P38 and active caspase 3 were decreased by BzATP plus Hydrochloride (p38 MAPK antagonist) and increased vy BBG plus Asiatic acid (p38 MAPK agonist), while the protein levels of phosphorylated ERK and NF-kappaB were decreased with BzATP plus Nimbolide (ERK antagonist) and increased with BBG plus Saikosaponin C (ERK agonist).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	89-94	caspase 3	Rattus norvegicus	61-70	
28488233-9	2017	Finally, the protein levels of phosphorylated P38 and active caspase 3 were decreased by BzATP plus Hydrochloride (p38 MAPK antagonist) and increased vy BBG plus Asiatic acid (p38 MAPK agonist), while the protein levels of phosphorylated ERK and NF-kappaB were decreased with BzATP plus Nimbolide (ERK antagonist) and increased with BBG plus Saikosaponin C (ERK agonist).	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	276-281	caspase 3	Rattus norvegicus	61-70