PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15548520-0	2005	Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.	Methyl Methanesulfonate	176-199	DNA polymerase beta	Homo sapiens	28-47	
10931918-0	2000	DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide.	Methyl Methanesulfonate	81-104	DNA polymerase beta	Homo sapiens	0-19	
1905189-1	1991	DNA repair synthesis induced by methyl methanesulfonate in preconditioned HeLa cells in which DNA replicative synthesis had been highly suppressed was inhibited by aphidicolin (an inhibitor of DNA polymerases alpha and delta) and dideoxythymidine (ddThR, an inhibitor of DNA polymerase beta).	Methyl Methanesulfonate	32-55	DNA polymerase beta	Homo sapiens	271-290	
29156686-4	2017	AGS cells over-expressing Polbeta were resistant to 6-TG to a similar extent as when MLH1 was inactivated while inhibition of O6-methylguanine-DNA methyltransferase (MGMT) was required to detect resistance to MMS.	Methyl Methanesulfonate	209-212	DNA polymerase beta	Homo sapiens	26-33	
29156686-6	2017	Moreover, AGS cells mutated in Polbeta were hypersensitive to both 6-TG and MMS killing and their sensitivity was partially rescued by MLH1 silencing.	Methyl Methanesulfonate	76-79	DNA polymerase beta	Homo sapiens	31-38	
28684413-4	2017	Pol beta-knock-out was confirmed by enhanced sensitivity to methyl methanesulfonate-induced DNA damage.	Methyl Methanesulfonate	60-83	DNA polymerase beta	Homo sapiens	0-8	
26760506-5	2016	Cells harboring Pol beta R152C are sensitive to the DNA damaging agents methyl methanesulfonate (MMS) and H2O2.	Methyl Methanesulfonate	72-95	DNA polymerase beta	Homo sapiens	16-24	
26760506-5	2016	Cells harboring Pol beta R152C are sensitive to the DNA damaging agents methyl methanesulfonate (MMS) and H2O2.	Methyl Methanesulfonate	97-100	DNA polymerase beta	Homo sapiens	16-24	
24777061-4	2014	Pol beta expression rescued methyl methanesulfonate sensitivity in aprataxin (hnt3)- and FEN1 (rad27)-deficient yeast.	Methyl Methanesulfonate	28-51	DNA polymerase beta	Homo sapiens	0-8	
23144716-6	2012	Human Pol beta was expressed in S. cerevisiae, and this partially rescued the MMS hypersensitivity observed with rad27(fen1)-null cells.	Methyl Methanesulfonate	78-81	DNA polymerase beta	Homo sapiens	6-14	
15647510-0	2005	The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells.	Methyl Methanesulfonate	20-23	DNA polymerase beta	Homo sapiens	86-105	
15647510-4	2005	When replicating Pol beta null cells are treated with MMS, a rapid phosphorylation of histone H2AX is detected in the nuclei of S phase cells, indicating that double strand breaks (DSB) are formed in response to unrepaired SSB.	Methyl Methanesulfonate	54-57	DNA polymerase beta	Homo sapiens	17-25