PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1905189-1 1991 DNA repair synthesis induced by methyl methanesulfonate in preconditioned HeLa cells in which DNA replicative synthesis had been highly suppressed was inhibited by aphidicolin (an inhibitor of DNA polymerases alpha and delta) and dideoxythymidine (ddThR, an inhibitor of DNA polymerase beta). Methyl Methanesulfonate 32-55 DNA polymerase beta Homo sapiens 271-290 23144716-6 2012 Human Pol beta was expressed in S. cerevisiae, and this partially rescued the MMS hypersensitivity observed with rad27(fen1)-null cells. Methyl Methanesulfonate 78-81 DNA polymerase beta Homo sapiens 6-14 10931918-0 2000 DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide. Methyl Methanesulfonate 81-104 DNA polymerase beta Homo sapiens 0-19 15548520-0 2005 Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. Methyl Methanesulfonate 176-199 DNA polymerase beta Homo sapiens 28-47 15647510-0 2005 The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Methyl Methanesulfonate 20-23 DNA polymerase beta Homo sapiens 86-105 15647510-4 2005 When replicating Pol beta null cells are treated with MMS, a rapid phosphorylation of histone H2AX is detected in the nuclei of S phase cells, indicating that double strand breaks (DSB) are formed in response to unrepaired SSB. Methyl Methanesulfonate 54-57 DNA polymerase beta Homo sapiens 17-25 29156686-4 2017 AGS cells over-expressing Polbeta were resistant to 6-TG to a similar extent as when MLH1 was inactivated while inhibition of O6-methylguanine-DNA methyltransferase (MGMT) was required to detect resistance to MMS. Methyl Methanesulfonate 209-212 DNA polymerase beta Homo sapiens 26-33 28684413-4 2017 Pol beta-knock-out was confirmed by enhanced sensitivity to methyl methanesulfonate-induced DNA damage. Methyl Methanesulfonate 60-83 DNA polymerase beta Homo sapiens 0-8 29156686-6 2017 Moreover, AGS cells mutated in Polbeta were hypersensitive to both 6-TG and MMS killing and their sensitivity was partially rescued by MLH1 silencing. Methyl Methanesulfonate 76-79 DNA polymerase beta Homo sapiens 31-38 24777061-4 2014 Pol beta expression rescued methyl methanesulfonate sensitivity in aprataxin (hnt3)- and FEN1 (rad27)-deficient yeast. Methyl Methanesulfonate 28-51 DNA polymerase beta Homo sapiens 0-8 26760506-5 2016 Cells harboring Pol beta R152C are sensitive to the DNA damaging agents methyl methanesulfonate (MMS) and H2O2. Methyl Methanesulfonate 72-95 DNA polymerase beta Homo sapiens 16-24 26760506-5 2016 Cells harboring Pol beta R152C are sensitive to the DNA damaging agents methyl methanesulfonate (MMS) and H2O2. Methyl Methanesulfonate 97-100 DNA polymerase beta Homo sapiens 16-24