PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15846088-5 2005 The cell line that showed greatest reduction (85-90%) of p53 expression showed decreased p21 promoter activation after DNA damage with camptothecin, etoposide and MMS. Methyl Methanesulfonate 163-166 H3 histone pseudogene 16 Homo sapiens 89-92 26276860-0 2016 Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21. Methyl Methanesulfonate 57-80 H3 histone pseudogene 16 Homo sapiens 121-124 26276860-6 2016 Trx1 overexpression and small interfering RNA knockdown in cells revealed that reduced Trx1 after exposure to lower doses of MMS attenuated DNA damage, assessed by comet assay, and level of the DNA-damage marker histone gamma-H2AX, possibly through scavenging intracellular ROS and an increase in p21 protein level via enhancing its stability. Methyl Methanesulfonate 125-128 H3 histone pseudogene 16 Homo sapiens 297-300