PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29438506-6 2018 Deletion of AFT1 and AFT2 along with base excision repair pathway DNA glycosylase MAG1 renders the aft1Deltaaft2Deltamag1Delta mutant highly sensitive to MMS. Methyl Methanesulfonate 154-157 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 82-86 31320474-2 2019 Mag1 initiates the base excision repair pathway by removing alkylated bases from DNA, and Tpa1 has been proposed to directly repair alkylated bases as does the prototypical oxidative dealkylase AlkB from Escherichia coli However, we found that in vivo repair of methyl methanesulfonate (MMS)-induced alkylation damage in DNA involves Mag1 but not Tpa1. Methyl Methanesulfonate 262-285 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 0-4 31320474-2 2019 Mag1 initiates the base excision repair pathway by removing alkylated bases from DNA, and Tpa1 has been proposed to directly repair alkylated bases as does the prototypical oxidative dealkylase AlkB from Escherichia coli However, we found that in vivo repair of methyl methanesulfonate (MMS)-induced alkylation damage in DNA involves Mag1 but not Tpa1. Methyl Methanesulfonate 287-290 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 0-4 31320474-3 2019 We observed that yeast strains without tpa1 are no more sensitive to MMS than WT yeast, whereas mag1-deficient yeast are ~500-fold more sensitive to MMS. Methyl Methanesulfonate 149-152 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 96-100 25897129-2 2015 Combinatorial deletions reveal that the H2A and H3 N-tails are important for the removal of MMS-induced DNA lesions due to their role in regulating the basal and MMS-induced expression of DNA glycosylase Mag1. Methyl Methanesulfonate 162-165 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 204-208 27298254-5 2016 We find that the Shu complex promotes high-fidelity bypass of MMS-induced alkylation damage, such as N3-methyladenine, as well as bypassing the abasic sites generated after Mag1 removes N3-methyladenine lesions. Methyl Methanesulfonate 62-65 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 173-177 25897129-2 2015 Combinatorial deletions reveal that the H2A and H3 N-tails are important for the removal of MMS-induced DNA lesions due to their role in regulating the basal and MMS-induced expression of DNA glycosylase Mag1. Methyl Methanesulfonate 92-95 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 204-208 18693109-4 2008 Deletion of MAG1, a gene encoding a DNA glycosylase and member of the base excision repair (BER) pathway, increased the biosensor"s sensitivity to the alkylating agents methyl methanesulfonate (MMS) (lowering the sensitivity threshold to 0.0001% (v/v)) and ethyl methanesulfonate (EMS). Methyl Methanesulfonate 169-192 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 12-16 21456053-5 2011 Luciferase activities were particularly enhanced in mutant strains with mms2 Delta and mag1 Delta by exposure to MMS, rad59 Delta and mlh1 Delta to camptothecin and mms2 Delta and mlh1 Delta to mitomycin C, respectively, compared with their parent strains. Methyl Methanesulfonate 113-116 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 87-91 18693109-4 2008 Deletion of MAG1, a gene encoding a DNA glycosylase and member of the base excision repair (BER) pathway, increased the biosensor"s sensitivity to the alkylating agents methyl methanesulfonate (MMS) (lowering the sensitivity threshold to 0.0001% (v/v)) and ethyl methanesulfonate (EMS). Methyl Methanesulfonate 194-197 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 12-16 12024048-6 2002 The galactose-inducible transcription of the GAL2, GAL7, and GAL10 genes is reduced in MMS-treated rad26 Delta cells and also in mag1 Delta rad14 Delta cells, whereas a very severe reduction in transcription occurs in MMS-treated mag1 Delta rad14 Delta rad26 Delta cells. Methyl Methanesulfonate 87-90 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 230-234 9157248-1 1997 MAG1 encodes a Saccharomyces cerevisiae 3-methyladenine DNA glycosylase that initiates a base-excision-repair pathway and protects yeast cells from killing by methylating agents such as methyl methanesulphonate (MMS). Methyl Methanesulfonate 212-215 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 0-4 18267974-7 2008 Monitoring BER in single and multiple glycosylase and AP-endonuclease mutants confirmed that Mag1 is the major enzyme that removes MMS-damaged bases. Methyl Methanesulfonate 131-134 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 93-97 14697759-4 2004 We previously reported that yeast cells deficient in the two AP endonucleases (apn1 apn2 double mutant) are extremely sensitive to killing by a model DNA alkylating agent methyl methanesulfonate (MMS) and that this sensitivity can be reduced by deleting the MAG1 3-methyladenine DNA glycosylase gene. Methyl Methanesulfonate 171-194 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 258-262 14697759-4 2004 We previously reported that yeast cells deficient in the two AP endonucleases (apn1 apn2 double mutant) are extremely sensitive to killing by a model DNA alkylating agent methyl methanesulfonate (MMS) and that this sensitivity can be reduced by deleting the MAG1 3-methyladenine DNA glycosylase gene. Methyl Methanesulfonate 196-199 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 258-262 9506896-5 1998 However, mag1 and apn1 mutants that are also defective in nucleotide excision repair are extremely sensitive to MMS-induced killing and the effects are synergistic. Methyl Methanesulfonate 112-115 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 9-13 9157248-1 1997 MAG1 encodes a Saccharomyces cerevisiae 3-methyladenine DNA glycosylase that initiates a base-excision-repair pathway and protects yeast cells from killing by methylating agents such as methyl methanesulphonate (MMS). Methyl Methanesulfonate 186-210 DNA-3-methyladenine glycosylase II Saccharomyces cerevisiae S288C 0-4