PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23144716-3 2012 In S. cerevisiae, Rad27(Fen1) was suggested to protect against MMS-induced cytotoxicity by excising multinucleotide flaps generated during repair. Methyl Methanesulfonate 63-66 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 18-23 24777061-4 2014 Pol beta expression rescued methyl methanesulfonate sensitivity in aprataxin (hnt3)- and FEN1 (rad27)-deficient yeast. Methyl Methanesulfonate 28-51 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 89-93 24777061-4 2014 Pol beta expression rescued methyl methanesulfonate sensitivity in aprataxin (hnt3)- and FEN1 (rad27)-deficient yeast. Methyl Methanesulfonate 28-51 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 95-100 23144716-3 2012 In S. cerevisiae, Rad27(Fen1) was suggested to protect against MMS-induced cytotoxicity by excising multinucleotide flaps generated during repair. Methyl Methanesulfonate 63-66 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 24-28 23144716-6 2012 Human Pol beta was expressed in S. cerevisiae, and this partially rescued the MMS hypersensitivity observed with rad27(fen1)-null cells. Methyl Methanesulfonate 78-81 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 113-118 23144716-6 2012 Human Pol beta was expressed in S. cerevisiae, and this partially rescued the MMS hypersensitivity observed with rad27(fen1)-null cells. Methyl Methanesulfonate 78-81 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 119-123 23144716-9 2012 These results suggest that after MMS exposure, the 5"-dRP group in the repair intermediate is cytotoxic and that Rad27(Fen1) protection against MMS in wild-type cells is due to elimination of the 5"-dRP group. Methyl Methanesulfonate 144-147 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 113-118 23144716-9 2012 These results suggest that after MMS exposure, the 5"-dRP group in the repair intermediate is cytotoxic and that Rad27(Fen1) protection against MMS in wild-type cells is due to elimination of the 5"-dRP group. Methyl Methanesulfonate 144-147 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 119-123 12893088-7 2003 While generally similar findings were observed with RAD2, overexpression of RAD2, but not EXO1, suppressed the MMS sensitivity of the rad27 null mutant cells. Methyl Methanesulfonate 111-114 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 134-139 15329499-6 2004 We found that the yeast Rad27 protein complements sensitivity to methyl methanesulfonate in an E. coli mutant. Methyl Methanesulfonate 65-88 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 24-29 7876174-5 1995 The rth1 delta mutation does not affect UV or gamma-ray sensitivity but enhances sensitivity to the alkylating agent methyl methanesulfonate. Methyl Methanesulfonate 117-140 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 4-8 9927726-3 1999 The rad27 deletion mutants are highly sensitive to methylmethane sulfonate (MMS). Methyl Methanesulfonate 51-74 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 4-9 9927726-3 1999 The rad27 deletion mutants are highly sensitive to methylmethane sulfonate (MMS). Methyl Methanesulfonate 76-79 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 4-9 9927726-4 1999 By examining the role of Rad27 in different modes of DNA excision repair, we wish to understand why the cytotoxic effect of MMS is dramatically enhanced in the absence of Rad27. Methyl Methanesulfonate 124-127 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 25-30 9927726-8 1999 Surprisingly, we found that Apn1 endonuclease sensitizes rad27 mutant cells to MMS. Methyl Methanesulfonate 79-82 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 57-62 9927726-9 1999 Deleting the APN1 gene largely restored the resistance of rad27 mutants to MMS. Methyl Methanesulfonate 75-78 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 58-63 9852084-6 1998 In addition, expression from the Xenopus cDNAs complemented the temperature and methyl methanesulfonate sensitivity of a yeast rad27 deletion, which eliminates the endogenous FEN-1 gene product. Methyl Methanesulfonate 80-103 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 127-132 9852084-6 1998 In addition, expression from the Xenopus cDNAs complemented the temperature and methyl methanesulfonate sensitivity of a yeast rad27 deletion, which eliminates the endogenous FEN-1 gene product. Methyl Methanesulfonate 80-103 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 175-180 9837987-3 1998 All four rad27 mutants showed similar high levels of mitotic recombination, but varied in their growth rate at various temperatures, and sensitivity to the DNA damaging agent methyl methane sulfonate. Methyl Methanesulfonate 175-199 multifunctional nuclease RAD27 Saccharomyces cerevisiae S288C 9-14