PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28195382-0	2017	Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage.	Methyl Methanesulfonate	86-109	ATR serine/threonine kinase	Homo sapiens	24-27	
19261547-2	2009	Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA-damaging agents such as methyl methanesulfonate (MMS) or the DNA replication inhibitor hydroxyurea (HU).	Methyl Methanesulfonate	152-175	ATR serine/threonine kinase	Homo sapiens	69-78	
21130714-1	2011	Treatment of PARP-1-expressing cells with the combination of a DNA methylating agent (MMS) and the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN) leads to an ATR/Chk1-dependent S phase checkpoint and cell death by apoptosis.	Methyl Methanesulfonate	86-89	ATR serine/threonine kinase	Homo sapiens	159-162	
20670884-2	2010	(2010) show that Mec1 (hATR) promotes the association of Slx4 and Rtt107 with Dpb11 (hTopBP1) in response to MMS-induced DNA alkylation, suggesting that Slx4 and Rtt107 might coordinate repair factors specifically at damaged replication forks.	Methyl Methanesulfonate	109-112	ATR serine/threonine kinase	Homo sapiens	17-21	
20670884-2	2010	(2010) show that Mec1 (hATR) promotes the association of Slx4 and Rtt107 with Dpb11 (hTopBP1) in response to MMS-induced DNA alkylation, suggesting that Slx4 and Rtt107 might coordinate repair factors specifically at damaged replication forks.	Methyl Methanesulfonate	109-112	ATR serine/threonine kinase	Homo sapiens	23-27	
12670903-7	2003	A similar increased sensitivity to the alkylating agent methyl methanesulfonate (MMS) was also observed for siRNA-mediated ATR silencing.	Methyl Methanesulfonate	56-79	ATR serine/threonine kinase	Homo sapiens	123-126	
18375193-0	2008	The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR.	Methyl Methanesulfonate	4-27	ATR serine/threonine kinase	Homo sapiens	92-95	
18375193-4	2008	Using ATM- and ATR-defective cells and an ATM specific kinase inhibitor we demonstrate for the first time that the MMS-induced S-phase checkpoint requires both ATM and ATR.	Methyl Methanesulfonate	115-118	ATR serine/threonine kinase	Homo sapiens	15-18	
18375193-4	2008	Using ATM- and ATR-defective cells and an ATM specific kinase inhibitor we demonstrate for the first time that the MMS-induced S-phase checkpoint requires both ATM and ATR.	Methyl Methanesulfonate	115-118	ATR serine/threonine kinase	Homo sapiens	168-171	
18375193-6	2008	These results support the hypothesis that after MMS-treatment, the presence of unresolved BER intermediates gives rise to lesions that activate both ATM and ATR and that during the consequent S-phase delay, such intermediates may be repaired by a recombinational pathway which involves the Rad51 protein.	Methyl Methanesulfonate	48-51	ATR serine/threonine kinase	Homo sapiens	157-160	
12670903-7	2003	A similar increased sensitivity to the alkylating agent methyl methanesulfonate (MMS) was also observed for siRNA-mediated ATR silencing.	Methyl Methanesulfonate	81-84	ATR serine/threonine kinase	Homo sapiens	123-126	
12417725-4	2002	In yng2, MMS treatment causes a persistent Mec1-dependent intra-S-phase checkpoint delay characterized by slow DNA repair.	Methyl Methanesulfonate	9-12	ATR serine/threonine kinase	Homo sapiens	43-47