PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18845679-2 2008 We show that in human cells, PCNA is monoubiquitinated in response to methyl methanesulfonate and mitomycin C, as well as UV light, albeit with different kinetics, but not in response to bleomycin or camptothecin. Methyl Methanesulfonate 70-93 proliferating cell nuclear antigen Homo sapiens 29-33 11687589-2 2002 Here, we demonstrate that the wild type FEN-1 binds tightly to chromatin in conjunction with proliferating cell nuclear antigen (PCNA) recruitment after MMS treatment, and the nuclease-defective FEN-1 increased the sensitivity of the cells to methylmethane sulfonate (MMS) and to UV light but not to ionizing radiation. Methyl Methanesulfonate 153-156 proliferating cell nuclear antigen Homo sapiens 93-127 11687589-2 2002 Here, we demonstrate that the wild type FEN-1 binds tightly to chromatin in conjunction with proliferating cell nuclear antigen (PCNA) recruitment after MMS treatment, and the nuclease-defective FEN-1 increased the sensitivity of the cells to methylmethane sulfonate (MMS) and to UV light but not to ionizing radiation. Methyl Methanesulfonate 153-156 proliferating cell nuclear antigen Homo sapiens 129-133 22479651-10 2012 RNAi experiments suggest that Cdt1 proteolysis in response to MMS depends on the presence of the sliding clamp PCNA. Methyl Methanesulfonate 62-65 proliferating cell nuclear antigen Homo sapiens 111-115 20353596-7 2010 Cisplatin, methylmethane sulphonate and benzo(a)pyrene-diol-epoxide induce the polyubiquitination of PCNA to the same extent as UV while polyubiquitination is not detected after X-ray treatment. Methyl Methanesulfonate 11-35 proliferating cell nuclear antigen Homo sapiens 101-105 9600342-3 1998 Treatment with the alkylating agents methylmethane sulfonate and N-methyl-N"-nitro-N-nitrosoguanidine resulted in the rapid and dose-dependent increase in the nuclear binding of PCNA. Methyl Methanesulfonate 37-60 proliferating cell nuclear antigen Homo sapiens 178-182 9600342-10 1998 In these conditions, treatment with hydrogen peroxide or methylmethane sulfonate, resulted in an increase in nuclear-bound PCNA in the G1 and in the G2 + M compartments, but not in S phase. Methyl Methanesulfonate 57-80 proliferating cell nuclear antigen Homo sapiens 123-127 25505145-0 2015 Roles of PCNA ubiquitination and TLS polymerases kappa and eta in the bypass of methyl methanesulfonate-induced DNA damage. Methyl Methanesulfonate 80-103 proliferating cell nuclear antigen Homo sapiens 9-13 25505145-6 2015 Compared to cell lines deficient for PCNA modification (Pcna(K164R)) or Polkappa, double mutant cell lines display hypersensitivity to MMS but not to BPDE or UV-C. Methyl Methanesulfonate 135-138 proliferating cell nuclear antigen Homo sapiens 37-41 23029527-9 2012 Cdt1 degradation was also induced by DNA damaging chemicals such as methyl methanesulfonate (MMS) or zeocin, depending on PCNA and CRL4-Cdt2, though it was less caffeine-sensitive. Methyl Methanesulfonate 68-91 proliferating cell nuclear antigen Homo sapiens 122-126 23029527-9 2012 Cdt1 degradation was also induced by DNA damaging chemicals such as methyl methanesulfonate (MMS) or zeocin, depending on PCNA and CRL4-Cdt2, though it was less caffeine-sensitive. Methyl Methanesulfonate 93-96 proliferating cell nuclear antigen Homo sapiens 122-126 19221475-2 2009 We have shown that this modification of PCNA is necessary for the survival of cells after UV-irradiation and methyl methanesulfonate, that it is independent of cell cycle checkpoint activation, and that it persists after UV damage has been removed. Methyl Methanesulfonate 109-132 proliferating cell nuclear antigen Homo sapiens 40-44 18845679-4 2008 Failure to ubiquitinate PCNA results in substantial sensitivity to UV and methyl methanesulfonate, but not to camptothecin or bleomycin. Methyl Methanesulfonate 74-97 proliferating cell nuclear antigen Homo sapiens 24-28 17130289-6 2006 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. Methyl Methanesulfonate 96-119 proliferating cell nuclear antigen Homo sapiens 22-26 17130289-6 2006 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. Methyl Methanesulfonate 96-119 proliferating cell nuclear antigen Homo sapiens 134-138 17130289-6 2006 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. Methyl Methanesulfonate 121-124 proliferating cell nuclear antigen Homo sapiens 22-26 17130289-6 2006 SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC13 (E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination. Methyl Methanesulfonate 121-124 proliferating cell nuclear antigen Homo sapiens 134-138 17085973-10 2006 The association of TRF2 with the chromatin and promoter region of the proliferating cell nuclear antigen (PCNA) gene, a putative target of TRF2, was increased by MMS treatment. Methyl Methanesulfonate 162-165 proliferating cell nuclear antigen Homo sapiens 70-104 17085973-10 2006 The association of TRF2 with the chromatin and promoter region of the proliferating cell nuclear antigen (PCNA) gene, a putative target of TRF2, was increased by MMS treatment. Methyl Methanesulfonate 162-165 proliferating cell nuclear antigen Homo sapiens 106-110 16407842-4 2006 Here, we show that PCNA ubiquitination in human cells is notably augmented after UV irradiation and other genotoxic treatments such as hydroxyurea, aphidicolin and methylmethane sulfonate. Methyl Methanesulfonate 164-187 proliferating cell nuclear antigen Homo sapiens 19-23 15381075-3 2004 However, several hours after treatment with methyl methanesulfonate (MMS) Triton-insoluble form of GFP-hRad18 accumulates in S-phase nuclei where it colocalizes with PCNA. Methyl Methanesulfonate 44-67 proliferating cell nuclear antigen Homo sapiens 166-170 15381075-3 2004 However, several hours after treatment with methyl methanesulfonate (MMS) Triton-insoluble form of GFP-hRad18 accumulates in S-phase nuclei where it colocalizes with PCNA. Methyl Methanesulfonate 69-72 proliferating cell nuclear antigen Homo sapiens 166-170