PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25310987-3 2014 Here, we show that Rad5(HLTF/SHPRH), which mediates the error-free branch, has a major role in the response to DNA damage caused by methyl methanesulfonate (MMS) during chromosome replication, whereas translesion synthesis polymerases make only a minor contribution. Methyl Methanesulfonate 132-155 helicase like transcription factor Homo sapiens 24-28 25310987-3 2014 Here, we show that Rad5(HLTF/SHPRH), which mediates the error-free branch, has a major role in the response to DNA damage caused by methyl methanesulfonate (MMS) during chromosome replication, whereas translesion synthesis polymerases make only a minor contribution. Methyl Methanesulfonate 157-160 helicase like transcription factor Homo sapiens 24-28 33281189-0 2020 The HLTF-PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate. Methyl Methanesulfonate 99-122 helicase like transcription factor Homo sapiens 4-8 21396873-6 2011 In contrast, MMS promotes the degradation of HLTF and the interactions of SHPRH with Rad18 and polymerase kappa. Methyl Methanesulfonate 13-16 helicase like transcription factor Homo sapiens 45-49 21504827-2 2011 (2011) describe how HLTF and SHPRH, the human homologs of yeast Rad5, can discriminate between MMS-induced versus UV-induced DNA damage. Methyl Methanesulfonate 95-98 helicase like transcription factor Homo sapiens 20-24 33281189-4 2020 The depletion of HLTF and PARP1 increases chromosome breaks, further reduces the length of replication tracks, and concomitantly increases the number of stalled forks after methyl methanesulfonate treatment according to a DNA fiber analysis. Methyl Methanesulfonate 173-196 helicase like transcription factor Homo sapiens 17-21 32192191-2 2020 Here we show that HLTF, SHPRH and HLTF/SHPRH knockout cell lines show different sensitivities towards UV-irradiation, methyl methanesulfonate (MMS), cisplatin and mitomycin C (MMC), which are drugs that induce different types of DNA lesions. Methyl Methanesulfonate 118-141 helicase like transcription factor Homo sapiens 18-22 32192191-2 2020 Here we show that HLTF, SHPRH and HLTF/SHPRH knockout cell lines show different sensitivities towards UV-irradiation, methyl methanesulfonate (MMS), cisplatin and mitomycin C (MMC), which are drugs that induce different types of DNA lesions. Methyl Methanesulfonate 118-141 helicase like transcription factor Homo sapiens 34-38 32192191-2 2020 Here we show that HLTF, SHPRH and HLTF/SHPRH knockout cell lines show different sensitivities towards UV-irradiation, methyl methanesulfonate (MMS), cisplatin and mitomycin C (MMC), which are drugs that induce different types of DNA lesions. Methyl Methanesulfonate 143-146 helicase like transcription factor Homo sapiens 18-22 32192191-2 2020 Here we show that HLTF, SHPRH and HLTF/SHPRH knockout cell lines show different sensitivities towards UV-irradiation, methyl methanesulfonate (MMS), cisplatin and mitomycin C (MMC), which are drugs that induce different types of DNA lesions. Methyl Methanesulfonate 143-146 helicase like transcription factor Homo sapiens 34-38 32192191-3 2020 In general, the HLTF/SHPRH double knockout cell line was less sensitive than the single knockouts in response to all drugs, and interestingly, especially to MMS and cisplatin. Methyl Methanesulfonate 157-160 helicase like transcription factor Homo sapiens 16-20 32192191-4 2020 Using the SupF assay, we detected an increase in the mutation frequency in HLTF knockout cells both after UV- and MMS-induced DNA lesions, while we detected a decrease in mutation frequency over UV lesions in the HLTF/SHPRH double knockout cells. Methyl Methanesulfonate 114-117 helicase like transcription factor Homo sapiens 75-79