PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17084916-2	2006	The GADD45A gene is responsive to a variety of DNA-damaging agents, including ionizing radiation (IR), methyl methanesulfonate (MMS), and ultraviolet (UV) radiation.	Methyl Methanesulfonate	103-126	growth arrest and DNA damage inducible alpha	Homo sapiens	4-11	
17084916-2	2006	The GADD45A gene is responsive to a variety of DNA-damaging agents, including ionizing radiation (IR), methyl methanesulfonate (MMS), and ultraviolet (UV) radiation.	Methyl Methanesulfonate	128-131	growth arrest and DNA damage inducible alpha	Homo sapiens	4-11	
7478567-4	1995	In contrast, the increase in p53 protein, WAF1/CIP1(p21) and GADD45 mRNA expression following exposure to the alkylating agent methylmethane sulphonate (25 and 100 micrograms ml-1) was similar in both cell types.	Methyl Methanesulfonate	127-151	growth arrest and DNA damage inducible alpha	Homo sapiens	61-67	
10747892-2	2000	Gadd45, a p53-regulated stress protein, plays an important role in the cell cycle G(2)-M checkpoint following exposure to certain types of DNA-damaging agents such as UV radiation and methylmethane sulfonate.	Methyl Methanesulfonate	184-207	growth arrest and DNA damage inducible alpha	Homo sapiens	0-6	
10097101-7	1999	Human cells with endogenous Gadd45 expression reduced by antisense GADD45 expression have an impaired G2/M checkpoint after exposure to either ultraviolet radiation or methyl methanesulfonate but are still able to undergo G2 arrest after ionizing radiation.	Methyl Methanesulfonate	168-191	growth arrest and DNA damage inducible alpha	Homo sapiens	28-34	
10097101-7	1999	Human cells with endogenous Gadd45 expression reduced by antisense GADD45 expression have an impaired G2/M checkpoint after exposure to either ultraviolet radiation or methyl methanesulfonate but are still able to undergo G2 arrest after ionizing radiation.	Methyl Methanesulfonate	168-191	growth arrest and DNA damage inducible alpha	Homo sapiens	67-73	
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Methyl Methanesulfonate	135-158	growth arrest and DNA damage inducible alpha	Homo sapiens	179-185	
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Methyl Methanesulfonate	160-163	growth arrest and DNA damage inducible alpha	Homo sapiens	179-185	
9927186-7	1999	Similarly, the inhibitory effect of Bcl-2 protein was seen in a GADD45 promoter reporter construct after treatment with methylmethane sulfonate or UV-radiation.	Methyl Methanesulfonate	120-143	growth arrest and DNA damage inducible alpha	Homo sapiens	64-70	
8892753-3	1996	In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53.	Methyl Methanesulfonate	101-104	growth arrest and DNA damage inducible alpha	Homo sapiens	237-243	
8226988-1	1993	The gadd45 gene is transcriptionally activated through at least two different mechanisms; one following treatment with base-damaging agents such as methylmethane sulfonate and UV radiation and the other following ionizing radiation.	Methyl Methanesulfonate	148-171	growth arrest and DNA damage inducible alpha	Homo sapiens	4-10	
8321226-4	1993	IR, UV radiation, and methylmethane sulfonate were found to induce p53 activity when a stably integrated reporter construct containing functional p53-binding sites was used and also in mobility shift assays with a p53-binding site from the GADD45 gene, and IR-inducible gene previously associated with growth arrest.	Methyl Methanesulfonate	22-45	growth arrest and DNA damage inducible alpha	Homo sapiens	240-246	
1990262-4	1991	After 20 Gy of X rays, gadd45 induction, as measured by increased amounts of mRNA, was similar to that produced by the most effective dose of the alkylating agent methyl methanesulfonate.	Methyl Methanesulfonate	163-186	growth arrest and DNA damage inducible alpha	Homo sapiens	23-29